Promethease: An Alternative DNA Health Option

What does Promethease do?

Promethease is a third party service which provides health related information based on DNA ancestry raw data from companies such as 23andme and others. After the brief FDA ban on 23andme, Promethease and other companies stepped in to fill the gap.

Post FDA ban, 23andMe could only provide the ancestry reports and the raw data information from the ancestry DNA test. The raw data file contains a list of rsIDs of SNPs. It also includes the relative chromosome position and the exact nucleotide base change at that position.

The 23andme raw data is of little use to people who do not have a background in genetics and biostatistics. However, the raw data file can be used to obtain health related information such as nutrient requirements, predispositions to complex and monogenic genetic conditions, allergies, carrier status, individual status of well-studied genes like MTHFR and BRCA1 and BRCA2 from service providers such as Promethease and Xcode Life.

Update: Late last year (2019) in September, MyHeritage acquired Promethease and SNPedia.

MyHeritage offered Promethease free of charge through the end of 2019 and continues to maintain SNPedia as a free resource for academic and non-profit users. For Non-European users, the DNA raw data will be shifted to MyHeritage into new accounts which will be created for them. However, the users will retain the ownership of their DNA raw data file and are free to delete it from MyHeritage’s server.

How to read Promethease results?

Promethease reports are based on SNPedia, a Wikipedia-styled repository. Promethease retrieves all relevant literature from the SNPedia database. This takes around 15 minutes. The report is organized in a single rs ID format. This means that the gene markers are listed by their dbSNP identifier with the potential risk provided next to it.

The red border indicates that the particular SNP has a bad implication for you. An explanation is provided in the grey box below with links to the respective references from SNPedia.

Sometimes you will see a similar passage below a gs ID. The gs IDs represent a genoset, which refers to a group of SNPs that affect the same phenotype (shown below). They may or may not mention the rsIDs of the SNP. Promethease is full of such terminologies that you may want to familiarize yourself with first before you dive into your reports. The adjoining table indicates the Repute, Magnitude and Geno time. Explanation for all three can be found here.

It is relevant to point out here that the Promethease report is not a result of analysis or algorithms. It is just a literature-retrieval system. Multiple polymorphisms influence human health conditions and traits. Predispositions to complex health conditions are analyzed using algorithms that take into account the combined effect of these polymorphisms.

A lot of conflicting information is published on these actively researched diseases on a regular basis. Interpreting these needs expert-curation. For example, if you select Acute Lymphoblastic Leukemia (ALL) from the side menu, Promethease might dig out 3 sources that indicate your increased risk for ALL (bad repute), 1 for decreased risk (good repute) and 2 which are neutral or repute not set. They are not weighed against each other to give you a strong case of yes or no.

What is Promethease Repute?

Repute according to the SNPedia website applies to a single genotype. The repute of a genotype maybe good, bad or not set. Since the Promethease report follows the single rsID format, the repute for each genotype is give in a table adjoining the passage along with magnitude and geno time. Unfortunately, this form of presenting can be misinterpreted by individuals who are using the Promethease report to make lifestyle alterations.

For example rs4132601(G;T) confers a bad repute for ALL according to the report. This does not mean that you rush off to an oncologist demanding an explanation. It only shows that there is literature evidence for that SNP to have a relatively strong genetic influence on ALL. Many diseases have multiple genetic components along with other external factors. Moreover, not all studies report the same findings. This may change when a larger study with a better sample population gives a different result.

If you do not want to see the repute color codes, you can choose the color-blind option and read your report without any visual bias.

23andMe Health Report vs Promethease Health Report vs Xcode Health Report

Human health is the manifestation of a complex interplay between genetics and the environment. In this light Promethease reports tend to set off a panic attack in people who do not have technical background. Health reports from Xcode Life and 23andMe

You can read a more in-depth comparative analysis between health reports from Xcode and Promethease or refer to the table below. Xcode now offers all the inherited health conditions covered in the 23andme health report in their Carrier Status report. The genetic risk factors covered in the 23andme health report is covered in the Xcode Health report.

Drug (A-C)	Gene	Guidelines	Drug (D-N)	Gene	Guidelines	Drug (O-Z)	Gene	Guidelines
(R)-methadone;(S)-EDDP;methadone	UGT2B7	PGX	Dabigatran	CES1	PGX	o-desmethyltramadol;tramadol	RFPL4B	PGX
3,4-methylenedioxymethamphetamine	SLC6A2	PGX	daclatasvir;peginterferon alfa-2a;peginterferon alfa-2b;ribavirin	IFNL3;IFNL4	PGX	olanzapine	ABCB1	PGX
abacavir	HLA-B	CPIC	dalcetrapib	ADCY9	PGX	olanzapine	BDNF	PGX
abacavir	HLA-B	DPWG	dapsone	HLA-DRB1	PGX	olanzapine	GIPR	PGX
abacavir	HLA-B	FDA	daptomycin	ABCB1	PGX	olanzapine;perphenazine	RGS4	PGX
abacavir	LST1;LTA;LTB	PGX	darifenacin	CYP2D6	FDA	olanzapine;risperidone	DRD2	PGX
abiraterone;prednisolone	DSE;TSPYL1	PGX	dasatinib;imatinib	ABCG2	PGX	olanzapine;risperidone	HTR2A	PGX
ABT-751	UGT1A4	PGX	dasatinib;imatinib;nilotinib	ABCG2	PGX	omeprazole	CYP2C19	CPIC
acamprosate	GRIN2B	PGX	daunorubicin	NOS3	PGX	omeprazole	CYP2C19	DPWG
Ace Inhibitors;Plain	XPNPEP2	PGX	debrisoquine	CYP2D6	PGX	omeprazole	CYP2C19	FDA
Ace Inhibitors;Plain;Angiotensin II Antagonists;Beta Blocking Agents;digoxin;diuretics;spironolactone	ADRB2	PGX	deferasirox	ABCG2	PGX	omeprazole	ABCB1	PGX
Ace Inhibitors;Plain;Angiotensin II Antagonists;Beta Blocking Agents;digoxin;diuretics;spironolactone	NOS3	PGX	deferasirox	UGT1A3	PGX	ondansetron	CYP2D6	CPIC
acenocoumarol	CYP4F2	PGX	deferiprone	UGT1A6	PGX	ondansetron	ABCB1	PGX
acenocoumarol	VKORC1	PGX	deleobuvir;faldaprevir	IFNL3;IFNL4	PGX	Opioid anesthetics;Other general anesthetics;volatile anesthetics	OPRM1	PGX
acenocoumarol;phenprocoumon	VKORC1	PGX	desflurane	CACNA1S	PGX	opioids	OPRM1	PGX
acenocoumarol;warfarin	APOE	PGX	desflurane;enflurane;halothane;isoflurane;methoxyflurane;sevoflurane;succinylcholine	RYR1	PGX	Opium alkaloids and derivatives	CHRNA3	PGX
acetaldehyde	ALDH2	PGX	desipramine	CYP2D6	CPIC	Opium alkaloids and derivatives	CHRNA5	PGX
acetaldehyde	PGM1	PGX	desipramine	CYP2D6	FDA	oseltamivir	ABCB1	PGX
acetaminophen	TRPV1	PGX	desipramine	MC1R	PGX	oxaliplatin	ABCB1	PGX
acetaminophen	UGT1A	PGX	desloratadine	HRH1	PGX	oxazepam	UGT2B15	PGX
acetaminophen;aspirin;diclofenac;propionic acid derivatives;Pyrazolones	PLA2G4A	PGX	desloratadine;mizolastine	FCER1A	PGX	oxcarbazepine	HLA-B	CPIC
acetaminophen;ibuprofen;loxoprofen;salicylamide		PGX	deutetrabenazine	CYP2D6	FDA	oxcarbazepine	HLA-B	FDA
acetaminophen;tramadol	OPRM1	PGX	dexamethasone	SERPINE1	PGX	oxcarbazepine	ABCB1	PGX
acetylcholine	ACE	PGX	dexamethasone;doxorubicin;vincristine	ABCB1	PGX	oxycodone	COMT	PGX
acetylcysteine	TOLLIP	PGX	dexamethasone;lenalidomide	ABCB1	PGX	paclitaxel	ABCB1	PGX
adalimumab	ATG16L1	PGX	dexlansoprazole	CYP2C19	CPIC	paclitaxel;Platinum compounds	CASP7	PGX
adalimumab	HFE	PGX	dexlansoprazole	CYP2C19	FDA	paliperidone	MC4R	PGX
adalimumab;certolizumab pegol;etanercept;glucocorticoids;infliximab;methotrexate	KLRD1	PGX	dexmedetomidine	ADRA2A	PGX	pantoprazole	CYP2C19	CPIC
adalimumab;etanercept;infliximab	FCGR3A	PGX	dextroamphetamine;methylphenidate	DRD1	PGX	pantoprazole	CYP2C19	DPWG
adalimumab;etanercept;infliximab;Tumor necrosis factor alpha (TNF-alpha) inhibitors	TRAF1	PGX	diazepam	CYP2C19	FDA	pantoprazole	CYP2C19	FDA
adalimumab;infliximab	FCGR2A	PGX	dicloxacillin	ABCB1	PGX	pantoprazole	ABCB1	PGX
adefovir dipivoxil	SLC22A6	PGX	didanosine	NT5C2	PGX	paroxetine	CYP2D6	CPIC
adefovir dipivoxil;cidofovir;tenofovir	SLC22A6	PGX	difluorodeoxyuridine	CDA	PGX	paroxetine	CYP2D6	DPWG
adrenergics, inhalants		PGX	digoxin	ABCB1	PGX	paroxetine	CYP2D6	FDA
agomelatine	ABCB1	PGX	Dihydropyridine derivatives	NOS1AP	PGX	paroxetine	CYP1A2	PGX
alemtuzumab;chlorambucil;cyclophosphamide;fludarabine;prednisone;rituximab;vincristine	CXCL12	PGX	diltiazem	PLCD3	PGX	paroxetine	HTR1A	PGX
alendronate	VDR	PGX	dimethyl fumarate	GSTP1	PGX	pazopanib	HLA-B	FDA
alfentanil	OPRM1	PGX	Dipeptidyl peptidase 4 (DPP-4) inhibitors	CDKAL1	PGX	pazopanib	UGT1A1	FDA
Alkylating Agents	EGFR	PGX	direct acting antivirals	IFNL4	PGX	peginterferon alfa-2a	IFNL3;IFNL4	PGX
Alkylating Agents;cisplatin	ESR1	PGX	disopyramide	KCNH2	PGX	peginterferon alfa-2a;peginterferon alfa-2b	IFNL3;IFNL4	PGX
allopurinol	HLA-B	CPIC	disulfiram	SLC6A3	PGX	peginterferon alfa-2a;peginterferon alfa-2b;ribavirin	IFNL3	PGX
allopurinol	HLA-B	FDA	diuretics	PDE4D	PGX	peginterferon alfa-2a;peginterferon alfa-2b;ribavirin	IFNL3;IFNL4	PGX
allopurinol	ABCG2	PGX	diuretics;hydrochlorothiazide	NEDD4L	PGX	peginterferon alfa-2a;peginterferon alfa-2b;ribavirin	IFNL4	PGX
allopurinol	CYCSP5	PGX	dobutamine	ADRB1	PGX	peginterferon alfa-2a;peginterferon alfa-2b;ribavirin;simeprevir	IFNL4	PGX
allopurinol;febuxostat	AOX1	PGX	docetaxel	CYP3A4	PGX	peginterferon alfa-2a;peginterferon alfa-2b;ribavirin;telaprevir	IFNL3	PGX
allopurinol;febuxostat	UGT1A1;UGT1A10;UGT1A3;UGT1A4;UGT1A5;UGT1A6;UGT1A7;UGT1A8;UGT1A9	PGX	docetaxel	SLCO1B3	PGX	peginterferon alfa-2a;peginterferon alfa-2b;ribavirin;telaprevir	IFNL3;IFNL4	PGX
alprazolam	CYP3A;CYP3A4	PGX	docetaxel	VEGFA	PGX	peginterferon alfa-2a;ribavirin	SCARB1	PGX
amantadine;Anticholinergics;Dopamine agonists;levodopa;selegiline	SLC22A1	PGX	docetaxel;doxorubicin	AKR1C3	PGX	peginterferon alfa-2a;ribavirin	VDR	PGX
amifampridine	NAT2	FDA	docetaxel;epirubicin	MDM4	PGX	peginterferon alfa-2b	HLA-DPA1	PGX
amifampridine phosphate	NAT2	FDA	docetaxel;FEC100;gemcitabine;trastuzumab;zoledronate	PPCDC	PGX	peginterferon alfa-2b;protease inhibitors;ribavirin	SLC28A2	PGX
amiloride;spironolactone	CYP4A11	PGX	docetaxel;gemcitabine;paclitaxel;Platinum compounds;vinorelbine	CASP7	PGX	peginterferon alfa-2b;ribavirin	ITPA	PGX
aminoglycoside antibacterials	MT-RNR1	PGX	docetaxel;thalidomide	CHST3	PGX	pemetrexed	GGH	PGX
amiodarone	NOS1AP	PGX	dolasetron;granisetron	NOS1AP	PGX	pemetrexed	MTHFR	PGX
amiodarone;Antibiotics;antipsychotics;diuretics;quinidine;sotalol	KCNE1	PGX	dolutegravir	UGT1A1	FDA	perindopril	BDKRB1	PGX
amisulpride	MC4R	PGX	dolutegravir	ABCG2	PGX	perphenazine	CYP2D6	FDA
amisulpride;antipsychotics;olanzapine;quetiapine;risperidone	HTR1A	PGX	donepezil	CYP2D6	FDA	Pertussis vaccines	TLR4	PGX
amisulpride;aripiprazole;clozapine;lithium;mirtazapine;olanzapine;paliperidone;quetiapine;risperidone;valproic acid	SH2B1	PGX	donepezil	BCHE	PGX	phenazepam	CYP2C19	PGX
amitriptyline	CYP2C19	CPIC	donepezil	CHAT	PGX	phenobarbital	ABCB1	PGX
amitriptyline	CYP2D6	CPIC	donepezil;galantamine;rivastigmine	CHAT	PGX	phenobarbital;phenytoin	MTHFR	PGX
amitriptyline	CYP2D6	DPWG	donepezil;galantamine;rivastigmine	CHRNA7	PGX	phenprocoumon	VKORC1	PGX
amitriptyline	CYP2D6	FDA	doxepin	CYP2C19	CPIC	phenytoin	CYP2C9	DPWG
amitriptyline;antidepressants;citalopram;fluvoxamine;paroxetine;sertraline;venlafaxine	ABCB1	PGX	doxepin	CYP2C19	FDA	phenytoin	CFHR4	PGX
amitriptyline;antidepressants;citalopram;paroxetine;venlafaxine	ABCB1	PGX	doxepin	CYP2D6	CPIC	phenytoin	SCN1A	PGX
amitriptyline;citalopram;fluoxetine;paroxetine;sertraline;venlafaxine	ABCB1	PGX	doxepin	CYP2D6	DPWG	photodynamic therapy	F13A1	PGX
amitriptyline;citalopram;paroxetine;venlafaxine	ABCB1	PGX	doxepin	CYP2D6	FDA	pimozide	CYP2D6	DPWG
amlodipine	CYP3A4	PGX	doxorubicin	ABCC1	PGX	pimozide	CYP2D6	FDA
amlodipine;chlorthalidone	NPPA	PGX	doxorubicin	CBR3	PGX	pioglitazone	ADIPOQ	PGX
amlodipine;chlorthalidone;lisinopril	ACE	PGX	doxorubicin;doxorubicinol	CBR1	PGX	piroxicam	CYP2C9	CPIC
amlodipine;chlorthalidone;lisinopril	AGT	PGX	doxorubicin;idarubicin	CYBA	PGX	piroxicam	CYP2C9	FDA
amodiaquine	CYP2C8	PGX	doxorubicin;methotrexate;prednisolone;vincristine	ABCB1	PGX	pitavastatin	ABCC2	PGX
amodiaquine;pyrimethamine;sulfadoxine	G6PD	PGX	dronabinol	CYP2C9	FDA	pitrakinra	IL4R	PGX
amoxapine	CYP2D6	FDA	Drug(s)	Gene	PGX	platinum	ERCC5	PGX
amoxicillin;clavulanate	HLA-DQB1	PGX	Drugs For Treatment Of Tuberculosis	NAT2	PGX	Platinum compounds	GSTP1	PGX
amphetamine	CYP2D6	FDA	Drugs For Treatment Of Tuberculosis;isoniazid	ABCB1	PGX	Platinum compounds	HSPA5	PGX
amphetamine	DRD2	PGX	Drugs For Treatment Of Tuberculosis;rifampin	RIPOR2	PGX	Platinum compounds	XRCC1	PGX
amphetamine;cannabinoids;cocaine;opioids	KAT2B	PGX	Drugs used in alcohol dependence	GATA4	PGX	Platinum compounds;radiotherapy		PGX
amprenavir	SLCO1B1	PGX	Drugs Used In Diabetes	IRS1	PGX	Platinum compounds;taxanes	ABCB1	PGX
Analgesics	KCNJ6	PGX	Drugs used in nicotine dependence;nicotine	CHRNA3	PGX	pramipexole	DRD3	PGX
Analgesics;Antiinflammatory agents, non-steroids;Ergot alkaloids;opioids;sumatriptan	COMT	PGX	Drugs used in nicotine dependence;nicotine;varenicline	CHRNA5	PGX	prasugrel	CYP2C19	PGX
Analgesics;Antiinflammatory agents, non-steroids;Ergot alkaloids;opioids;sumatriptan	OPRM1	PGX	duloxetine	NCAM1	PGX	pravastatin	KIF6	PGX
anastrozole	CYP19A1	PGX	duloxetine	ZNF385D	PGX	pravastatin	SLCO1B1	PGX
anastrozole;exemestane	MAP4K4	PGX	eculizumab	C5	PGX	pravastatin;simvastatin	HMGCR	PGX
anastrozole;exemestane;letrozole	CYP19A1	PGX	eculizumab	CR1	PGX	prednisone;tacrolimus	ABCB1	PGX
anastrozole;letrozole	TNFRSF11B	PGX	efavirenz	CYP2B6	CPIC	pregabalin	SLC7A5	PGX
anastrozole;letrozole	TNFSF11	PGX	efavirenz	CYP2B6	DPWG	prochlorperazine	ANKK1;DRD2	PGX
angiotensin II	AGTR1	PGX	efavirenz	CYP2B6	FDA	propafenone	CYP2D6	DPWG
anthracyclines and related substances	CBR3	PGX	efavirenz	CYP2B6	PGX	propafenone	CYP2D6	FDA
anthracyclines and related substances	HAS3	PGX	efavirenz;lopinavir;Nucleoside and nucleotide reverse transcriptase inhibitors;ritonavir		PGX	propofol	CYP2B6	PGX
anthracyclines and related substances;cyclophosphamide;doxorubicin;epirubicin;fluorouracil;methotrexate;oxaliplatin;Platinum compounds	NOS3	PGX	efavirenz;nelfinavir	ABCB1	PGX	propofol;remifentanil	ABCB1	PGX
anthracyclines and related substances;taxanes	ABCB1	PGX	egfr inhibitors	EGFR	PGX	propranolol	CYP2D6	FDA
Antibiotics	LGALS3	PGX	elagolix	SLCO1B1	FDA	propranolol	ADRB2	PGX
antidepressants	HTR2A	PGX	eliglustat	CYP2D6	DPWG	protriptyline	CYP2D6	FDA
antidepressants	SLC6A4	PGX	eliglustat	CYP2D6	FDA	quetiapine	COMT	PGX
antidepressants;antiepileptics;Beta Blocking Agents;calcium channel blockers	ACE	PGX	enalapril		PGX	quetiapine	MC4R	PGX
antidepressants;antipsychotics;benzodiazepine derivatives;opioids;Sympathomimetics	OPRM1	PGX	enalapril	ACE	PGX	quinapril	AGT	PGX
antidepressants;benzodiazepine derivatives;mirtazapine;Selective serotonin reuptake inhibitors	GAL	PGX	enalapril;imidapril;lisinopril	BDKRB2	PGX	rabeprazole	CYP2C19	FDA
antidepressants;citalopram	CREB1;METTL21A	PGX	endoxifen		PGX	radiotherapy	CDK1	PGX
antidepressants;citalopram;clomipramine;lithium;nefazodone;paroxetine;venlafaxine	FKBP5	PGX	enflurane	CACNA1S	PGX	raloxifene	UGT1A8	PGX
antidepressants;citalopram;escitalopram;fluoxetine;paroxetine	TPH1	PGX	entacapone	COMT	PGX	raltegravir	UGT1A1	FDA
antidepressants;citalopram;fluoxetine	SERPINE1	PGX	Enzymes	A2M	PGX	ramipril	ACE	PGX
antidepressants;citalopram;fluvoxamine;paroxetine;sertraline;venlafaxine	ABCB1	PGX	ephedrine;phenylephrine	ADRB2	PGX	ranibizumab	NRP1	PGX
antidepressants;citalopram;paroxetine	BDNF	PGX	epirubicin;fluorouracil;oxaliplatin	NQO1	PGX	rasagiline	DRD2	PGX
antidepressants;desipramine;fluoxetine	BDNF	PGX	erdafitinib	CYP2C9	FDA	regadenoson	AMPD1	PGX
antidepressants;fluvoxamine;paroxetine;Selective serotonin reuptake inhibitors;sertraline	HTR1A	PGX	erlotinib	EGFR	PGX	remifentanil	COMT	PGX
antidepressants;mirtazapine;venlafaxine	TPH2	PGX	erythromycin	ABCC2	PGX	remifentanil;sevoflurane	ABCB1	PGX
antidepressants;Selective serotonin reuptake inhibitors	FKBP5	PGX	escitalopram	CYP2C19	CPIC	repaglinide	CYP2C8	PGX
antidepressants;Selective serotonin reuptake inhibitors;venlafaxine	GRIA3	PGX	escitalopram	CYP2C19	DPWG	repaglinide	NEUROD1	PGX
antiepileptics	ABCB1	PGX	escitalopram	CYP2C19	FDA	rhodamine 123	ABCB1	PGX
antiepileptics;carbamazepine	ABCB1	PGX	escitalopram	BMP5	PGX	rifampin	NR1I2	PGX
antiepileptics;carbamazepine;lamotrigine;oxcarbazepine;phenytoin;topiramate	SCN2A	PGX	escitalopram	CYP1A2	PGX	risperidone	CYP2D6	DPWG
antiepileptics;carbamazepine;oxcarbazepine	ABCC2	PGX	escitalopram;nortriptyline	BDNF	PGX	risperidone	CYP2D6	FDA
antiepileptics;carbamazepine;phenobarbital;phenytoin;valproic acid	SCN2A	PGX	esomeprazole	CYP2C19	FDA	risperidone	HTR2C	PGX
Antihypertensives	ATP2B1	PGX	esomeprazole	STAT6	PGX	risperidone	MC4R	PGX
Antihypertensives And Diuretics In Combination	NOS3	PGX	estradiol		PGX	ritodrine	CACNA1C	PGX
Antihypertensives;Antihypertensives And Diuretics In Combination;diuretics	NOS3	PGX	etanercept	TNF	PGX	ritonavir	APOC3	PGX
Antihypertensives;Beta Blocking Agents	GRK5	PGX	ethambutol;isoniazid;pyrazinamide;rifampin	CYP2C9	PGX	rituximab	FCGR3A	PGX
Antiinflammatory agents, non-steroids	CDKN2B-AS1	PGX	ethanol	ADH1B	PGX	rivastigmine	BCHE	PGX
Antiinflammatory agents, non-steroids	PTGS1	PGX	ethanol	OPRM1	PGX	rocuronium	ABCB1	PGX
Antiinflammatory agents, non-steroids;aspirin		PGX	etoposide	ABCB1	PGX	rofecoxib	PTGS2	PGX
Antiinflammatory agents, non-steroids;celecoxib;diclofenac	CYP2C9	PGX	etoposide	SLIT1	PGX	rosiglitazone	PAX4	PGX
antineoplastic agents	SERPINA3	PGX	etravirine	CYP2C19	PGX	rosuvastatin	SLCO1B1	FDA
antineoplastic agents	TP53	PGX	everolimus	PIK3R1	PGX	rosuvastatin	ABCG2	PGX
antipsychotics	BDNF	PGX	everolimus	RPTOR	PGX	rosuvastatin	SLCO1B1	PGX
antipsychotics	GRM3	PGX	exemestane	CYP19A1	PGX	salbutamol	ADRB2	PGX
antipsychotics;aripiprazole;bromperidol;chlorpromazine;clozapine;nemonapride;olanzapine;risperidone	DRD2	PGX	exemestane;letrozole	CYP19A1	PGX	salbutamol;selective beta-2-adrenoreceptor agonists	CRHR2	PGX
antipsychotics;aripiprazole;risperidone	ANKK1	PGX	exemestane;letrozole	ESR1	PGX	salmeterol	ADRB2	PGX
antipsychotics;chlorpromazine;fluphenazine;thioridazine;trifluoperazine	CYP1A2	PGX	Farglitazar;glibenclamide	SCNN1B	PGX	salvianolic acid b	NOS3	PGX
antipsychotics;clozapine;olanzapine	DRD2	PGX	fenofibrate	APOA5	PGX	selective beta-2-adrenoreceptor agonists	ARG1	PGX
antipsychotics;olanzapine;perphenazine;quetiapine;ziprasidone	RGS4	PGX	fenofibrate	CRP	PGX	Selective serotonin reuptake inhibitors	HTR7	PGX
antipsychotics;risperidone	LEP	PGX	fentanyl	ABCB1	PGX	sertraline	CYP2C19	CPIC
antithymocyte globulin	FCGR3A	PGX	fentanyl	OPRM1	PGX	sertraline	CYP2C19	DPWG
Antithyroid Preparations	HLA-B	PGX	fentanyl;morphine;opioids;oxycodone	RHBDF2	PGX	sertraline	GNB3;P3H3	PGX
Antivirals for treatment of HIV infections, combinations;Drugs For Treatment Of Tuberculosis	ABCB1	PGX	fentanyl;propofol;remifentanil;sevoflurane	ADRB2	PGX	sevoflurane	CACNA1S	PGX
Antivirals for treatment of HIV infections, combinations;ritonavir	APOE	PGX	fesoterodine	CYP2D6	FDA	sibutramine	GNB3	PGX
apixaban	ABCG2	PGX	fexofenadine	ABCB1	PGX	sildenafil	GNB3	PGX
aripiprazole	CYP2D6	DPWG	fexofenadine	SLCO2B1	PGX	silibinin	ABCB1	PGX
aripiprazole	CYP2D6	FDA	flecainide	CYP2D6	DPWG	simvastatin	SLCO1B1	FDA
aripiprazole	DRD2	PGX	flecainide	SCN4A	PGX	simvastatin	HMGCR	PGX
aripiprazole lauroxil	CYP2D6	FDA	flecainide;mexiletine	SCN4A	PGX	simvastatin	SLCO1B1	PGX
aripiprazole;clozapine;haloperidol;olanzapine;quetiapine;risperidone	FAAH	PGX	flecanide	CYP2D6	DPWG	simvastatin acid	SLCO1B1	PGX
aripiprazole;risperidone	DRD2	PGX	flibanserin	CYP2C19	FDA	siponimod	CYP2C9	FDA
artesunate;chlorproguanil;dapsone	G6PD	PGX	flucloxacillin	NR1I2	PGX	sirolimus	ABCB1	PGX
artesunate;primaquine;pyrimethamine;sulfadoxine	G6PD;IKBKG	PGX	fluindione	VKORC1	PGX	sirolimus;temsirolimus	NR1I2	PGX
asparaginase	NFATC2	PGX	flunisolide	TBXT	PGX	sitagliptin;vildagliptin	GLP1R	PGX
asparaginase;cyclophosphamide;cytarabine;daunorubicin;dexamethasone;doxorubicin;leucovorin;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine	GATA3	PGX	fluorouracil	DPYD	CPIC	SN-38	UGT1A9	PGX
asparaginase;cyclophosphamide;daunorubicin;prednisolone;vincristine	PNPLA3	PGX	fluorouracil	DPYD	DPWG	sofosbuvir	IFNL3;IFNL4	PGX
asparaginase;dexamethasone;methotrexate	PYGL	PGX	fluorouracil	DPYD	FDA	sofosbuvir;velpatasvir;voxilaprevir	IFNL3;IFNL4	PGX
aspirin	PPARG	PGX	fluorouracil	DPYD	PGX	somatropin recombinant	COL1A1	PGX
aspirin;Beta Blocking Agents;clopidogrel;hmg coa reductase inhibitors	NOS3	PGX	fluorouracil;FOLFIRI;FOLFOX	TYMS	PGX	sorafenib	KDR	PGX
aspirin;clopidogrel	ITGA2	PGX	fluorouracil;FOLFOX	TYMS	PGX	spironolactone	ACE	PGX
aspirin;clopidogrel;prasugrel	PEAR1	PGX	fluorouracil;irinotecan;leucovorin	ABCG1	PGX	stavudine	SAMHD1	PGX
aspirin;prasugrel	NTRK1;PEAR1	PGX	fluorouracil;irinotecan;leucovorin	ABCG2	PGX	succinylcholine	CACNA1S	PGX
ataluren	CFTR	PGX	fluorouracil;leucovorin;oxaliplatin	MTHFR	PGX	succinylcholine	BCHE	FDA
atazanavir	UGT1A1	CPIC	fluorouracil;oxaliplatin	PARD3B	PGX	succinylcholine;volatile anesthetics	RYR1	PGX
atazanavir	UGT1A2	CPIC	fluorouracil;Platinum compounds;radiotherapy	TMEM167A;XRCC4	PGX	sufentanil	COMT	PGX
atazanavir	UGT1A3	CPIC	fluorouracil;Platinum compounds;radiotherapy	XRCC4	PGX	sufentanil	OPRM1	PGX
atazanavir	NR1I2	PGX	fluoxetine	SLC6A4	PGX	sulfamethoxazole	GCLC	PGX
atazanavir	UGT1A1	PGX	fluoxetine;sertraline	ACE	PGX	sulfasalazine	ABCG2	PGX
atazanavir;lopinavir;ritonavir;tenofovir	ABCC2	PGX	flurbiprofen	CYP2C9	FDA	sulfinpyrazone	UGT1A9	PGX
atazanavir;ritonavir	UGT1A7	PGX	flurbiprofen	CYP2C9	PGX	sulfonamides, urea derivatives	TCF7L2	PGX
atenolol	DPYS	PGX	fluticasone propionate;montelukast	CA10	PGX	sulindac	FMO3	PGX
atenolol	GNB3	PGX	fluvastatin	ACE	PGX	sumatriptan	GNB3	PGX
atenolol;bisoprolol		PGX	fluvastatin	CETP	PGX	sunitinib	ABCB1	PGX
atenolol;hydrochlorothiazide	ALDH1A2	PGX	fluvastatin	SLCO1B1	PGX	sunitinib	FLT3	PGX
atenolol;hydrochlorothiazide;metoprolol	SLC25A31	PGX	fluvastatin;simvastatin	LIPC	PGX	tacrolimus	CYP3A5	CPIC
atenolol;irbesartan	EDN1	PGX	fluvoxamine	CYP2B6	CPIC	tacrolimus	CYP3A5	FDA
atenolol;metoprolol	ADRB2	PGX	fluvoxamine	COMT	PGX	tacrolimus	CYP3A4	PGX
atenolol;verapamil	CACNA1C	PGX	fluvoxamine	FGF2	PGX	talinolol	ABCB1	PGX
atomoxetine	CYP2D6	CPIC	fluvoxamine	HTR2A	PGX	tamoxifen	CYP2D6	CPIC
atomoxetine	CYP2D6	DPWG	fluvoxamine	CYP2D6	FDA	tamoxifen	CYP2D6	DPWG
atomoxetine	CYP2D6	FDA	fluvoxamine;milnacipran;paroxetine	HTR1A	PGX	tamoxifen	CYP2D6	FDA
atomoxetine	SLC6A2	PGX	fluvoxamine;paroxetine	HTR2A	PGX	tamoxifen	CYP19A1	PGX
atorvastatin	APOE	PGX	folic acid	MTHFR	PGX	tamoxifen	UGT1A4	PGX
atorvastatin	SLCO1B1	PGX	folic acid;methotrexate	TLR4	PGX	tamsulosin	CYP2D6	FDA
atorvastatin;Bisphosphonates	FDPS	PGX	folic acid;vitamin b-complex, plain	MTHFR	PGX	taxanes		PGX
atorvastatin;fluvastatin;hmg coa reductase inhibitors;lovastatin;pravastatin;simvastatin	HMGCR	PGX	folic acid;vitamin b-complex, plain	MTRR	PGX	tegafur	DPYD	DPWG
atorvastatin;hmg coa reductase inhibitors;pravastatin;simvastatin	HTR7	PGX	follitropin beta;thyrotropin alfa;urofollitropin	FSHR	PGX	tegafur	DPYD	PGX
atorvastatin;hmg coa reductase inhibitors;rosuvastatin	COQ2	PGX	forskolin	ABCB1	PGX	telaprevir	CYP24A1	PGX
atorvastatin;lovastatin;simvastatin	APOA5	PGX	furosemide	ABCC4	PGX	telmisartan	GNB3	PGX
atorvastatin;pravastatin;simvastatin	ABCA1	PGX	furosemide;spironolactone	ADD1	PGX	telmisartan	SLCO1B3	PGX
atorvastatin;quinapril	ACE	PGX	gabapentin	SLC7A5	PGX	temozolomide	ABCB1	PGX
atorvastatin;rifampin	SLCO1B1	PGX	galantamine	CYP2D6	FDA	tenofovir	ABCC4	PGX
atorvastatin;simvastatin	PON1	PGX	galantamine	CHAT	PGX	tenofovir disoproxil fumarate	CYP27B1	PGX
atorvastatin;simvastatin	RYR2	PGX	gefitinib	CYP2D6	FDA	tenoxicam	CYP2C9	CPIC
avatrombopag	CYP2C9	FDA	gefitinib	ABCB1	PGX	terbutaline	ADRB2	PGX
axitinib;sorafenib	HIF1A	PGX	gefitinib	EGFR	PGX	tetrabenazine	CYP2D6	FDA
azathioprine	NUDT15	CPIC	geldanamycin	EGFR	PGX	thalidomide	ERCC1	PGX
azathioprine	NUDT15	DPWG	gemcitabine	NT5C2	PGX	Thiazides, plain	GNB3	PGX
azathioprine	TPMT	CPIC	gemcitabine	RRM1	PGX	thiazolidinediones	AQP2	PGX
azathioprine	TPMT	DPWG	gemcitabine;paclitaxel	CDA	PGX	thioguanine	NUDT15	CPIC
azathioprine	TPMT	FDA	gemcitabine;paclitaxel	SLC29A1	PGX	thioguanine	TPMT	CPIC
azathioprine	FTO	PGX	gemcitabine;Platinum compounds	CASP7	PGX	thioguanine	TPMT	DPWG
azathioprine	NUDT15	PGX	gemcitabine;Platinum compounds	RRM1	PGX	thioguanine	TPMT	FDA
azathioprine;mercaptopurine		PGX	gemtuzumab ozogamicin	CD33	PGX	thioridazine	CYP2D6	FDA
azathioprine;mercaptopurine;thioguanine	NUDT15	PGX	glatiramer acetate		PGX	thioridazine	CYP2D6	PGX
azathioprine;purine analogues	ITPA	PGX	glibenclamide	NOS1AP	PGX	thiotepa	GSTP1	PGX
belinostat	UGT1A1	FDA	gliclazide	KCNJ11	PGX	tianeptine	OPRM1	PGX
benazepril	MTHFR	PGX	glimepiride	NOS1AP	PGX	ticagrelor	PEAR1	PGX
benazepril;imidapril	AGT	PGX	glipizide	NOS1AP	PGX	timolol		PGX
benazepril;perindopril	ACE	PGX	glucocorticoids	HSD3B1	PGX	tiotropium	ADRB2	PGX
Beta Blocking Agents	ADRB1	PGX	granisetron	ABCB1	PGX	tipifarnib	ABCB1	PGX
Beta Blocking Agents	GRK5	PGX	granisetron;palonosetron	ERCC1	PGX	tipiracil hydrochloride;trifluridine	SLC29A1	PGX
Beta blocking agents, selective	BST1	PGX	haloperidol	CYP2D6	DPWG	tocilizumab	IL6R	PGX
bevacizumab	ARMS2	PGX	haloperidol	MC4R	PGX	tolbutamide	CYP2C9	PGX
bevacizumab	CFH	PGX	haloperidol	SLC6A5	PGX	tolterodine	CYP2D6	FDA
bevacizumab	CXCR4	PGX	halothane	CACNA1S	PGX	topiramate	GRIK1	PGX
bevacizumab	EDN1	PGX	hdl cholesterol;letrozole;triglycerides	CYP19A1	PGX	topotecan	ABCG2	PGX
bevacizumab;capecitabine;cetuximab;oxaliplatin	MGAT4A	PGX	Hepatitis vaccines	IL4R	PGX	tramadol	CYP2D6	DPWG
bevacizumab;capecitabine;fluorouracil;irinotecan;leucovorin;oxaliplatin	VEGFA	PGX	heroin	OPRM1	PGX	tramadol	CYP2D6	FDA
bevacizumab;capecitabine;oxaliplatin	MGAT4A	PGX	heroin	SOD2	PGX	tramadol	OPRM1	PGX
bevacizumab;carboplatin;cisplatin;cyanocobalamin;folic acid;pemetrexed	MTHFR	PGX	heroin;methamphetamine	BDNF	PGX	trandolapril;verapamil	PTPRD	PGX
bevacizumab;fluorouracil;irinotecan;leucovorin	SHMT1	PGX	heroin;opioids	OPRM1	PGX	trastuzumab	ERBB2	PGX
bevacizumab;pegaptanib;ranibizumab	VEGFA	PGX	highly active antiretroviral therapy (haart)	OPRM1	PGX	trastuzumab	FCGR2A	PGX
bevacizumab;pemetrexed	GGH	PGX	hmg coa reductase inhibitors	LPA	PGX	triamcinolone	HCG22	PGX
bevacizumab;ranibizumab	VEGFA	PGX	hmg coa reductase inhibitors	SLCO1B1	PGX	trimipramine	CYP2C19	CPIC
bilirubin	UGT1A	PGX	hmg coa reductase inhibitors;letrozole	CYP19A1	PGX	trimipramine	CYP2D6	CPIC
bisantrene	ABCB1	PGX	hmg coa reductase inhibitors;simvastatin	GATM	PGX	trimipramine	CYP2D6	FDA
bisoprolol	ACY3	PGX	hormonal contraceptives for systemic use	F5	PGX	troglitazone		PGX
Bisphosphonates	ABCC4	PGX	Hydralazine-isosorbide dinitrate	GNB3	PGX	tropisetron	CYP2D6	CPIC
Bisphosphonates	FDPS	PGX	hydrochlorothiazide	ADD1	PGX	Tumor necrosis factor alpha (TNF-alpha) inhibitors	IL23R	PGX
Bisphosphonates;clodronate;etidronic acid;risedronate;tiludronate	IL1B	PGX	hydrochlorothiazide	KCNJ1	PGX	Tumor necrosis factor alpha (TNF-alpha) inhibitors	TNF	PGX
Bisphosphonates;pamidronate;zoledronate	CYP2C8	PGX	hydrocodone	OPRM1	PGX	Tumor necrosis factor alpha (TNF-alpha) inhibitors;ustekinumab	IL1B	PGX
bleomycin;cisplatin;etoposide	BLMH	PGX	hydroxyurea	MAP3K5	PGX	ustekinumab	TIRAP	PGX
bleomycin;cisplatin;etoposide	GSTP1	PGX	ibuprofen	PTGS2	PGX	valbenazine	CYP2D6	FDA
bleomycin;cyclophosphamide;doxorubicin;prednisone;rituximab;vincristine;vindesine	ABCB1	PGX	idarubicin	NCF4	PGX	valganciclovir	ABCB1	PGX
boceprevir;peginterferon alfa-2a;peginterferon alfa-2b;ribavirin	IFNL3;IFNL4	PGX	idarubicin	RAC2	PGX	valproic acid	POLG	PGX
bortezomib;dexamethasone;melphalan;prednisone	CTLA4	PGX	iloperidone	CYP2D6	FDA	valproic acid	UGT1A6	PGX
botulinum toxin type a	TRPV1	PGX	iloperidone	CYP2D6	PGX	vancomycin		PGX
brexpiprazole	CYP2D6	DPWG	imatinib	CYP2B6	PGX	vardenafil	CYP3A5	PGX
brexpiprazole	CYP2D6	FDA	imatinib	EGFR	PGX	varenicline	CHRNA4	PGX
brivaracetam	CYP2C19	FDA	imatinib	SLC22A1	PGX	venlafaxine	CYP2D6	DPWG
bucindolol	ADRB1	PGX	imatinib	SLC22A4	PGX	venlafaxine	CYP2D6	FDA
budesonide		PGX	imipramine	CYP2C19	CPIC	venlafaxine	HTR2A	PGX
budesonide;flunisolide;fluticasone propionate;glucocorticoids;nedocromil;triamcinolone	GLCCI1	PGX	imipramine	CYP2C19	DPWG	verapamil	KCNIP1;KCNMB1	PGX
bufuralol;dextromethorphan	CYP2D6	PGX	imipramine	CYP2D6	CPIC	vincristine	ABCB1	PGX
bumetanide;furosemide;torasemide	SLC12A3	PGX	imipramine	CYP2D6	DPWG	vincristine	CEP72	PGX
buprenorphine	COMT	PGX	imipramine	CYP2D6	FDA	vitamin e	CYP4F2	PGX
buprenorphine	OPRD1	PGX	imiquimod	TLR7	PGX	Vitamin K	CYP4F2	PGX
buprenorphine;fentanyl;meperidine;morphine;opioids;pentazocine		PGX	indinavir	CYP3A4	PGX	voriconazole	CYP2C19	CPIC
buprenorphine;fentanyl;tramadol	COMT	PGX	indinavir	UGT1A1	PGX	voriconazole	CYP2C19	DPWG
bupropion	GALR1	PGX	infliximab	TNF	PGX	voriconazole	CYP2C19	FDA
bupropion;Drugs used in nicotine dependence;nicotine;varenicline	CHRNA5	PGX	infliximab;Tumor necrosis factor alpha (TNF-alpha) inhibitors	TNFRSF1B	PGX	voriconazole	CYP3A4	PGX
bupropion;nicotine	DRD1	PGX	insulin recombinant;zinc acetate	SLC30A8	PGX	vortioxetine	CYP2D6	FDA
bupropion;nicotine;varenicline	CHRNA5	PGX	interferon alfa-2a, recombinant;interferon alfa-2b, recombinant;ribavirin	FTO	PGX	warfarin	CYP2C9	DPWG
busulfan	CYP2C9	PGX	interferon alfa-2a, recombinant;peginterferon alfa-2b	IDO1	PGX	warfarin	CYP2C9	FDA
busulfan;cyclophosphamide	CTH	PGX	interferon alfa-2b, recombinant;ribavirin	ITPA	PGX	warfarin	CYP4F2	FDA
butorphanol	COMT	PGX	interferon beta-1a	RORA	PGX	warfarin	VKORC1	FDA
caffeine	ADORA2A	PGX	interferon beta-1a;interferon beta-1b	HLA-DQA1	PGX	warfarin		PGX
caffeine	CYP1A2	PGX	interferon beta-1a;interferon beta-1b	IRF6	PGX	warfarin	CYP4F2	PGX
calcein	ABCB1	PGX	interferons	IFNL3;IFNL4	PGX	warfarin	VKORC1	PGX
calcein;lopinavir	ABCC2	PGX	interferons	STAT3	PGX	XK469	AOX1	PGX
calcium	VDR	PGX	interferons;peginterferon alfa-2a;peginterferon alfa-2b;ribavirin	IFNL3	PGX	zileuton	PRORP	PGX
calcium channel blockers	CACNA1C	PGX	interferons;ribavirin	IL18	PGX	zoledronate	FDPS	PGX
calcium channel blockers;nitrendipine	KCNH2	PGX	irbesartan	CYP2C9	PGX	zuclopenthixol	CYP2D6	DPWG
candesartan	AGTR1	PGX	irinotecan	UGT1A1	DPWG
cangrelor	P2RY12	PGX	irinotecan	UGT1A1	FDA
cannabinoids	FAAH	PGX	irinotecan	UGT1A1	PGX
cannabinoids;cocaine;ethanol;nicotine;opioids	OPRM1	PGX	irinotecan;raltitrexed	TYMS	PGX
capecitabine	DPYD	CPIC	isoflurane	CACNA1S	PGX
capecitabine	DPYD	FDA	isoniazid	BACH1	PGX
capecitabine	DPYD	PGX	isoniazid;phenytoin	NAT2	PGX
capecitabine	TYMS	PGX	isoniazid;pyrazinamide;rifampin	NAT2	PGX
capecitabine;docetaxel	CYP1A1	PGX	isoniazid;rifampin	GSTP1	PGX
capecitabine;epirubicin;platinum	GSTP1	PGX	isoproterenol	ADRB2	PGX
capecitabine;fluorouracil	HLA-G	PGX	ivacaftor	CFTR	PGX
capecitabine;fluorouracil;leucovorin;oxaliplatin	MTHFR	PGX	ivacaftor-lumacaftor	CFTR	PGX
capecitabine;fluorouracil;tegafur	TYMS	PGX	ivacaftor-tezacaftor	CFTR	PGX
capecitabine;oxaliplatin	PTGS2	PGX	ketorolac		PGX
capecitabine;radiotherapy	AREG	PGX	l-methylfolate;Vitamin B-complex, Incl. Combinations	MTHFR	PGX
captopril	ACE	PGX	l-phenylalanine	PAH	PGX
carbamazepine	HLA-A	CPIC	l-tryptophan	SLC22A2	PGX
carbamazepine	HLA-A	FDA	lamivudine;lopinavir;ritonavir;zidovudine	ABCB1	PGX
carbamazepine	HLA-B	CPIC	lamotrigine	UGT1A4	PGX
carbamazepine	HLA-B	FDA	lansoprazole	CYP2C19	CPIC
carbamazepine	CYP3A5	PGX	lansoprazole	CYP2C19	DPWG
carbamazepine	SCN1A	PGX	lansoprazole;omeprazole;rabeprazole	IL1B	PGX
carbamazepine;clobazam;ethosuximide;lamotrigine;levetiracetam;oxcarbazepine;valproic acid	SCN1A	PGX	lansoprazole;tacrolimus	ABCB1	PGX
carbamazepine;oxcarbazepine	SCN1A	PGX	lapatinib	HLA-DQA1	FDA
carbamazepine;phenobarbital;phenytoin;valproic acid	CYP1A1	PGX	lapatinib	HLA-DRB1	FDA
carbamazepine;phenytoin;valproic acid	GABRA1	PGX	latanoprost	ABCC4	PGX
carbocisteine	PAH	PGX	ledipasvir;sofosbuvir	IFNL3;IFNL4	PGX
carboplatin;cisplatin	EIF3A	PGX	leflunomide	ESR1	PGX
carboplatin;cisplatin;docetaxel;erlotinib;gefitinib;paclitaxel	MAP3K1	PGX	lenalidomide;thalidomide	CTNNB1	PGX
carboplatin;cisplatin;docetaxel;gemcitabine;paclitaxel	RAF1	PGX	letermovir	SLCO1B1	PGX
carboplatin;cisplatin;docetaxel;paclitaxel		PGX	letrozole	ESR1	PGX
carboplatin;cisplatin;fluorouracil	SLC19A1	PGX	levodopa	HOMER1	PGX
carboplatin;cisplatin;gemcitabine	GPX5	PGX	levodopa	SLC6A3	PGX
carboplatin;cisplatin;oxaliplatin;platinum;Platinum compounds	ERCC1	PGX	liraglutide	GLP1R	PGX
carboplatin;cyclophosphamide;thiotepa	ALDH1A1	PGX	lisinopril	ACE	PGX
carboplatin;docetaxel;paclitaxel	BCL2	PGX	lithium	ASIC2	PGX
carboplatin;docetaxel;trastuzumab	ERBB3	PGX	lithium;valproic acid		PGX
carboplatin;gemcitabine	CYP2C8	PGX	lofexidine	CYP2D6	FDA
carboplatin;lonafarnib;paclitaxel	FNTB	PGX	lopinavir	SLCO1B1	PGX
carboplatin;paclitaxel	MAD1L1	PGX	lorazepam	UGT2B15	PGX
carboplatin;paclitaxel	SLCO1B3	PGX	losartan	STK39	PGX
carboplatin;taxanes	GSR	PGX	lovastatin	LDLR	PGX
carisoprodol	CYP2C19	FDA	lovastatin acid	SLCO1B1	PGX
carvedilol	CYP2D6	FDA	lumacaftor	CFTR	PGX
carvedilol	ADRB2	PGX	lumefantrine	CYP3A4	PGX
catecholamines	ADRB1	PGX	lurasidone	HTR1A	PGX
catecholamines;metformin	SLC22A3	PGX	Measles vaccines	TLR3	PGX
cavosonstat	CFTR	PGX	meclizine	CYP2D6	FDA
cefotaxime	SLC22A8	PGX	meloxicam	CYP2C9	CPIC
ceftriaxone	ABCG2	PGX	melphalan	SLC7A5	PGX
celecoxib	CYP2C9	FDA	memantine	NR1I2	PGX
celecoxib	ALOX12	PGX	mephenytoin	CYP2C19	PGX
cerivastatin	SLCO1B1	PGX	mercaptopurine	NUDT15	CPIC
cetuximab	EGF	PGX	mercaptopurine	TPMT	CPIC
cetuximab;irinotecan;leucovorin;tegafur	EGFR	PGX	mercaptopurine	TPMT	FDA
cetuximab;irinotecan;panitumumab	AREG	PGX	mercaptopurine	FTO	PGX
cetuximab;panitumumab	KRAS	PGX	mercaptopurine	NUDT15	PGX
cevimeline	CYP2D6	FDA	mercaptopurine;methotrexate	ITPA	PGX
chlorothiazide;hydrochlorothiazide		PGX	metformin	SLC22A1	PGX
chlorpromazine;clozapine;haloperidol;olanzapine;quetiapine;risperidone;trifluoperazine	EPM2A	PGX	metformin	SLC47A1	PGX
chlorthalidone;lisinopril	MMP3	PGX	metformin;sulfonamides, urea derivatives	KCNJ11	PGX
cisplatin	ACYP2	PGX	methacholine	ADRB2	PGX
cisplatin	ERCC1	PGX	methadone	ABCB1	PGX
cisplatin;cyclophosphamide	CYP2E1	PGX	methadone	CYP3A4	PGX
cisplatin;cyclophosphamide	GSTM3	PGX	methamphetamine	FAAH	PGX
cisplatin;cyclophosphamide;doxorubicin;methotrexate;vincristine	ABCC3	PGX	methotrexate	ATIC	PGX
cisplatin;fluorouracil	GALNT14	PGX	methotrexate	MTHFR	PGX
cisplatin;fluorouracil;mitoxantrone	GALNT14	PGX	methotrexate	SLC19A1	PGX
cisplatin;fluorouracil;oxaliplatin	VEGFA	PGX	methoxyflurane	CACNA1S	PGX
cisplatin;fluorouracil;radiotherapy	MUTYH	PGX	methylphenidate	CES1	PGX
cisplatin;gemcitabine	RRM1	PGX	methylphenidate	DRD2	PGX
cisplatin;irinotecan	UBE2I	PGX	methylphenidate	SLC6A2	PGX
cisplatin;oxaliplatin;Platinum compounds	GSTP1	PGX	methylprednisolone;prednisolone	ABCB1	PGX
cisplatin;oxaliplatin;platinum;Platinum compounds	ERCC2;KLC3	PGX	metoclopramide	CYP2D6	FDA
cisplatin;pemetrexed	ABCC2	PGX	metoprolol	CYP2D6	DPWG
citalopram	CYP2C19	CPIC	metoprolol	CYP2D6	FDA
citalopram	CYP2C19	DPWG	metoprolol	ADRB1	PGX
citalopram	CYP2C19	FDA	midazolam	POR	PGX
citalopram	HTR2A	PGX	migalastat	GLA	PGX
citalopram;escitalopram		PGX	milnacipran	HTR1A	PGX
citalopram;fluoxetine	GSK3B	PGX	mirabegron	CYP2D6	FDA
citalopram;fluoxetine;paroxetine;sertraline	REEP5	PGX	mirtazapine	FKBP5	PGX
cladribine;cytarabine	RRM1	PGX	mirtazapine;venlafaxine	TPH2	PGX
cladribine;fluorouracil;gemcitabine	NT5C1A	PGX	mitotane	CYP2B6	PGX
clobazam	CYP2C19	FDA	mivacurium	BCHE	FDA
clodronate	VDR	PGX	modafinil	ABCB1	PGX
clomipramine	CYP2C19	CPIC	montelukast	LTA4H	PGX
clomipramine	CYP2C19	DPWG	morphine	KCNJ6	PGX
clomipramine	CYP2D6	CPIC	morphine	OPRM1	PGX
clomipramine	CYP2D6	DPWG	morphine;nortriptyline	ABCB1	PGX
clomipramine	CYP2D6	FDA	muraglitazar	EDN1	PGX
clomipramine;liothyronine;lithium;nefazodone;venlafaxine	HTR1B	PGX	mycophenolate mofetil	SLCO1B3	PGX
clomipramine;lithium;nefazodone;paroxetine;venlafaxine	ABCB1	PGX	mycophenolic acid	SLCO1B3	PGX
clomipramine;nefazodone;paroxetine;venlafaxine	FKBP5	PGX	naloxone	OPRM1	PGX
clonidine	GNB3	PGX	naltrexone	DBH	PGX
clopidogrel	CYP2C19	CPIC	naproxen	CYP2C9	PGX
clopidogrel	CYP2C19	DPWG	nateglinide	SLCO1B1	PGX
clopidogrel	CYP2C19	FDA	nebivolol	CYP2D6	FDA
clopidogrel	CES1	PGX	nelfinavir	CYP2C19	PGX
clozapine	CYP2D6	FDA	nemonapride	ANKK1	PGX
clozapine	ABCB1	PGX	nevirapine	CYP2B6	PGX
clozapine	HTR2C	PGX	nicotine	CHRNA3	PGX
clozapine	NTRK2	PGX	nicotine	CHRNA5	PGX
clozapine;olanzapine	MC4R	PGX	nicotine;Opium alkaloids and derivatives	CHRNA5	PGX
clozapine;olanzapine;risperidone	DRD2	PGX	nifedipine	SLC14A2	PGX
cocaine	DRD2	PGX	nilotinib	UGT1A1	FDA
cocaine	OPRM1	PGX	nimodipine	CACNA1C	PGX
cocaine;ethanol;nicotine	OPRM1	PGX	nitrendipine	AGTR1	PGX
cocaine;heroin	OPRM1	PGX	nitroprusside	ACE	PGX
codeine	CYP2D6	CPIC	nitrous oxide	MTHFR	PGX
codeine	CYP2D6	DPWG	nortriptyline	CYP2D6	CPIC
codeine	CYP2D6	FDA	nortriptyline	CYP2D6	DPWG
codeine	OPRM1	PGX	nortriptyline	CYP2D6	FDA
conjugated estrogens	SULT1A1	PGX	nortriptyline	ABCB1	PGX
conjugated estrogens;medroxyprogesterone	VDR	PGX	nortriptyline	GNB3	PGX
corticosteroids	BCL2L11	PGX
corticosteroids	CRHR1	PGX
corticosteroids;selective beta-2-adrenoreceptor agonists	ADRB2	PGX
cotinine	CHRNA5	PGX
cotinine glucuronide	UGT1A9	PGX
cotinine;nicotine	OPRM1	PGX
coumarin	CYP2A6	PGX
creatine	MOBP	PGX
curcumin;ivacaftor	CFTR	PGX
cyclophosphamide	ABCC4	PGX
cyclophosphamide	CYP2C19	PGX
cyclophosphamide	SOD2	PGX
cyclophosphamide;cytarabine;daunorubicin;mercaptopurine;methotrexate;prednisone;vincristine	DROSHA	PGX
cyclophosphamide;dexamethasone;lenalidomide;thalidomide	CTNNB1	PGX
cyclophosphamide;docetaxel	VEGFA	PGX
cyclophosphamide;docetaxel;doxorubicin;epirubicin;fluorouracil	SLCO1B1	PGX
cyclophosphamide;doxorubicin	CYP2C19	PGX
cyclophosphamide;doxorubicin;fluorouracil	ATM	PGX
cyclophosphamide;doxorubicin;fluorouracil	SLC22A16	PGX
cyclophosphamide;doxorubicin;fluorouracil;methotrexate	NOS3	PGX
cyclophosphamide;doxorubicin;prednisone;rituximab;vincristine	GSTA1	PGX
cyclophosphamide;epirubicin	GSTP1	PGX
cyclophosphamide;epirubicin;fluorouracil	NQO1	PGX
cyclophosphamide;epirubicin;fluorouracil	PIGB	PGX
cyclophosphamide;epirubicin;paclitaxel	CYP1B1	PGX
cyclophosphamide;fluorouracil;methotrexate	FGFR4	PGX
cyclosporine	CYP3A4	PGX
cyclosporine	CYP3A5	PGX
cyclosporine;dicloxacillin	ABCB1	PGX
cyclosporine;mycophenolate mofetil	IL10	PGX
cyclosporine;mycophenolate mofetil;sirolimus;tacrolimus	UGT1A8	PGX
cyclosporine;mycophenolic acid	ABCC2	PGX
cyclosporine;sirolimus;tacrolimus	TCF7L2	PGX
cyclosporine;tacrolimus	CRTC2	PGX
cysteamine	CFTR	PGX
cytarabine	CDA	PGX
cytarabine;daunorubicin;dexrazoxane;idarubicin	ABCB1	PGX
cytarabine;daunorubicin;etoposide;mitoxantrone	SLCO1B1	PGX
cytarabine;fludarabine;gemtuzumab ozogamicin;idarubicin	CYP2E1	PGX
cytarabine;idarubicin	NT5C3A	PGX

Concluding remarks

As often emphasized by genetic testing companies, the health related information provided by various third party providers are not for medical purposes. Only clinically certified tests can be used for such purposes. DNA ancestry tests such as those from 23andme, Ancestry DNA, Family Finder test from FTDNA are not clinically certified. Please bear in mind that the labs in which these tests are carried out may be certified, and many companies showcase this fact, but the certification of lab is not the same as the clinical certification of the test.

The only exception to this is a handful of traits reported by 23andme that are now FDA approved. All of the health traits reported by 23andme including the FDA approved traits are now covered in the Xcode Life health reports. One helpful consideration while evaluating the ancestry DNA tests is to look for the number of genetic markers being tested and the version of the chip. The 23andme v5 chip (GSA, Illumina) covers around 650,000 markers. Illumina has said that it is more health report-friendly than their OmniExpress versions that are still being used by companies like Ancestry DNA and Family Tree DNA. You can read more about the health markers covered in the 23andme v5 chip here. Living DNA also uses the same chip.

We recommend the 23andme ancestry test to clients who are interested in using the data for Xcode Life health reports. This is because of large number of health related markers present in the 23andme v5 chips which gives better health related information.

Health

Wellness

Promethease: An Alternative DNA Health Option

What does Promethease do?

Update: Late last year (2019) in September, MyHeritage acquired Promethease and SNPedia.

How to read Promethease results?

What is Promethease Repute?

23andMe Health Report vs Promethease Health Report vs Xcode Health Report

Concluding remarks

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