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The DNA Blog

April 20, 2017
Know Your Genes: LIPC “HDL Gene”

The hepatic lipase gene (LIPC) is associated with the synthesis of hepatic lipase enzyme (LIPC) which catalyzes the hydrolysis of fat. Hepatic lipase converts intermediate-density lipoprotein (IDL) to low-density lipoprotein (LDL).It is expressed in the liver and in the adrenal glands. Specific alleles of this gene are known to either increase or decrease hepatic lipase […]

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April 19, 2017
Know Your Genes: DRD2 “Dopamine Gene”

DRD2 gene: An introduction DRD2 is a protein-coding gene that is located on chromosome 11. The Dopamine Receptor Gene (DRD2) is associated with the synthesis of DRD2, which is the main receptor for all antipsychotic drugs. The hormone Dopamine is a neurotransmitter and its secretion is increased during emotional upheavals.   From an evolutionary aspect, this […]

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April 17, 2017
Know Your Genes: MTHFR “Folic Acid Gene”

The Methyl Tetra Hydrofolate Reductase gene (MTHFR) is associated with the synthesis of the MTHFR enzyme, which converts folate obtained from the diet into an active form. The active folate is involved in the re-methylation of homocysteine to methionine. MTHFR gene variations determine how the body utilizes folate from the diet. People with the T […]

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April 17, 2017
Know Your Genes: GC - “Vitamin D Gene”

The Group Specific Component globulin (GC) gene is associated with the synthesis of Group Specific Component globulin (GC), also called the Vitamin D Binding Protein (VDBP), which binds to vitamin D and its plasma metabolites, transporting them to the target tissue. This protein is synthesized by the hepatic parenchymal cells and then secreted into the […]

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April 10, 2017
Know Your Genes: INSIG2 “Insulin Gene”

The Insulin signaling protein type 2 gene (INSIG2) is associated with the synthesis of INSIG2 protein which interacts with transcription factors, activating the synthesis of cholesterol and fatty acids.  The variants of the INSIG2 gene have been shown to be associated with body fat accumulation. Specific alleles of this gene are known to either increase […]

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April 5, 2017
Know Your Genes: PPARA

The Peroxisome Proliferator- Activated Receptor (PPARA) gene is associated with the synthesis of Peroxisome Proliferator- Activated Receptor Alpha (PPARA), a protein associated with the activation of other genes and also in regulation of fatty acid oxidation during exercise. A lack of energy in the cells activate this gene like during endurance exercises or when fasting. […]

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March 24, 2017
Know Your Genes: MMP3 - “The Risk of Injury Gene”

The Matrix Metalloproteinase 3 (MMP3) gene is associated with the synthesis of matrix metalloproteinase 3 (also called Stromelysin-1), an enzyme which is associated with the breakdown of extra cellular matrix during the normal physiological process. MMP3 is required to maintain Extra Cellular Matrix (ECM) homeostasis and it contributes to the material integrity, as well as […]

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March 21, 2017
Know Your Genes: TNFA “The Inflammation Response Gene”

The Tumor Necrosis Factor Alpha (TNFA) gene is associated with the synthesis of TNFA, a pro-inflammatory cytokine that regulates immune responses such as inflammation. Specific alleles of this gene are known to either increase or decrease the levels of TNFA. People with the A variant of the gene are found to synthesize more TNFA which […]

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March 17, 2017
Know Your Genes: CASR - “The Calcium Gene”

CASR: The Calcium Gene The Calcium sensing receptor (CASR) gene is associated with the synthesis of Calcium sensing receptor, a receptor that binds to calcium present in the blood.  Specific alleles of this gene are known to either increase or decrease the sensitivity to calcium.  Variants of the gene are shown to be associated with the levels of Calcium, […]

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