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Know Your Genes: PPARA

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Endurance
Power
Aerobic Capacity
Cardiorespiratory Fitness

The Peroxisome Proliferator- Activated Receptor (PPARA) gene is associated with the synthesis of Peroxisome Proliferator- Activated Receptor Alpha (PPARA), a protein associated with the activation of other genes and also in regulation of fatty acid oxidation during exercise. A lack of energy in the cells activate this gene like during endurance exercises or when fasting. Variants of the gene are shown to be associated with endurance, power, aerobic capacity and cardio fitness (heart rate)

PPARA level is higher in tissues which catabolize fatty acids like skeletal and cardiac muscle and the liver while it is lower in other tissues like the pancreas

Association with Endurance:

In a study conducted on athletes, people with G variant were associated with endurance. A similar study conducted on soccer players showed that people with the G variant were highly represented. People with the G variant were found to have higher amount of slow twitch fibers.

Association with Power:

People with the C variant of the gene had better hand grip strength, thereby, better at power based activities than people with the G variant.

Association with Aerobic capacity:

People with the G variant were associated with higher oxygen consumption, thereby better aerobic capacity when compared with people with the C variant of the gene.

Association with Cardio fitness (Oxygen pulse):

People with the G variant were associated with higher values of oxygen pulse.

 

Genotype

rs4253778

PhenotypeRecommendation
GG

[Advantage] More likely to have better endurance

[Advantage] More likely to have more slow twitch fibers

[Advantage] More likely to have better aerobic capacity

[Advantage] More likely to have higher oxygen pulse

  • Likely better endurance
  • Include plenty of endurance based activities like dancing and playing cricket into the fitness routine
GCModerate power and endurance
CC[Advantage] More likely to have better power

[Advantage] More likely to have more fast twitch fibers

[Limitation] More likely to have lower aerobic capacity

[Limitation] More likely to have lower oxygen pulse

  • Likely better power
  • Include power based activities like kicking a football and squats into the fitness routine

 


References
:

  1. http://www.ommegaonline.org/article-details/Role-of-Peroxisome-Proliferator-Activated-Receptor-Alpha-(PPARA)-rs4253778-Polymorphism-in-Endurance-Phenotype/1152
  2. https://www.researchgate.net/publication/226721692_PPARa_gene_variation_and_physical_performance_in_Russian_athletes
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157815/
Find out which variation of the gene you carry and more at www.xcode.in

Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”

Amrita Surendranath
Amrita Surendranath
Amrita has a Masters in Human Genetics which fuelled her passion for genes and their diktats. She loves converting genetic research into exciting scientific news with a punch. 10 years on, her interesting insights have covered a range of topics that include cancer, diabetes, nutrition, fitness and more. A pulse on what’s interesting aids in decoding laboratory data into useful science that could empower people into molding healthier lifestyles.