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Know Your Genes: PPARD

The Peroxisome Proliferator- Activated Receptor Delta (PPARD) gene is associated with the synthesis of Peroxisome Proliferator- Activated Receptor Delta (PPARD), a protein associated with cell differentiation and lipid metabolism. Variations of this gene are associated with endurance and HDL cholesterol levels upon exercising.

Association with Endurance:

In a study conducted on athletes, people with the C variant were associated with endurance. In another similar study, people with the C variant were found to be associated with better endurance.

Association with HDL levels upon Exercising:

In a study on PPARD gene polymorphisms and lipid responses upon exercising, people with the C variant showed a greater increase in HDL-C levels. In a study conducted on 2700 study participants, PPARD gene polymorphisms were shown to be associated with changes in HDL levels upon exercising.

 

Genotype

Phenotype

Recommendation

CC

[Advantage] More likely to have better endurance

[Advantage] More likely to have higher HDL levels upon exercising

  • Include endurance based activities like swimming, long distance running, stair climbing and tennis to improve HDL levels
CT

Moderate endurance

TT

[Limitation] More likely to have lower endurance

[Limitation] More likely to have lower HDL levels upon exercising

  • Include endurance based activities in moderation

 

References:

  1. https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor_delta
  2. https://www.ncbi.nlm.nih.gov/pubmed/19383774
  3. https://www.ncbi.nlm.nih.gov/pubmed/26231489
  4. https://www.ncbi.nlm.nih.gov/pubmed/17259439

 

Find out which variation of the gene you carry and more at www.xcode.in

“Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”

Amrita Surendranath
Amrita Surendranath
Amrita has a Masters in Human Genetics which fuelled her passion for genes and their diktats. She loves converting genetic research into exciting scientific news with a punch. 10 years on, her interesting insights have covered a range of topics that include cancer, diabetes, nutrition, fitness and more. A pulse on what’s interesting aids in decoding laboratory data into useful science that could empower people into molding healthier lifestyles.