The β2 adrenergic receptor 2 (ADRB2) gene is associated with the synthesis of β2 adrenergic receptor 2, a cell membrane spanning receptor that binds to adrenaline. Specific alleles of this gene are known to either increase or decrease the sensitivity of the body to the effects of adrenaline. Variants of the gene are shown to be associated with changes in the heart rate, size of the bronchioles, transport of oxygen and utilization of fat during exercise. There are two single nucleotide polymorphisms associated with this gene, Arg16Gly and Gln27Glu.
Association with Running:[hr height=”30″ style=”default” line=”default” themecolor=”1″]
A study conducted on elite endurance athletes showed that people with the A variant (Arg16) of the gene were more common among elite endurance athletes than among sedentary individuals. In a study conducted on Olympus marathon runners, among people who stated that they preferred running as a sport, those with the A (Arg16) variant of the gene had faster timing.
Association with Aerobic Capacity:[hr height=”30″ style=”default” line=”default” themecolor=”1″]
People with the C variant (Gln27) of the gene were associated with better aerobic capacity and increase in VO2max after aerobic training when compared with people with the G variant of the gene.
Association with carbohydrate sensitivity induced obesity:[hr height=”30″ style=”default” line=”default” themecolor=”1″]
People with the G (Gln27Glu) variant of the gene are shown to be associated with increased sensitivity to carbohydrates in the diet, wherein a high intake of carbohydrate increases the risk for obesity. In another study that was conducted on women undergoing a 12 week energy restricted diet, it was found that people with the G (Gln27Glu) variant showed a greater reduction in body weight in response to the diet intervention.
Genotype
(Arg16Gly) |
Phenotype |
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AA |
|
AG |
|
GG |
|
Genotype
(Gln27Glu) |
Phenotype |
---|---|
CC |
|
CG |
|
GG |
|
[idea]
How can this information be used?
It is important to choose an appropriate diet based on the genetic profile.[/idea]
For people with A and C variant (Better Endurance Ability)[hr height=”30″ style=”default” line=”default” themecolor=”1″]
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For people with G variant (Low Endurance Ability)[hr height=”30″ style=”default” line=”default” themecolor=”1″]
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References:[hr height=”30″ style=”default” line=”default” themecolor=”1″]
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- https://www.dnafit.com/blog/gene_in_focus:_part_13_-_adrb2_3336.asp
- https://www.ncbi.nlm.nih.gov/pubmed/?term=12888635
- https://www.ncbi.nlm.nih.gov/pubmed/20044476
- https://www.ncbi.nlm.nih.gov/pubmed/17998016
- http://onlinelibrary.wiley.com/doi/10.1038/oby.2010.130/full
- https://www.ncbi.nlm.nih.gov/pubmed/?term=25761120%5Buid%5D
[idea]Find out which variation of the gene you carry and more at www.www.xcode.in[/idea]
“Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”