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Know Your Genes: PPARG “Weight Regain Gene”

The peroxisome proliferator activated receptor (PPARG) gene is associated with the synthesis of peroxisome proliferator activated receptor, a nuclear receptor found mainly in the adipose tissue, macrophages and colon.  PPARG is shown to be associated with fatty acid storage and glucose metabolism.

Association with Obesity:

In a study conducted on 387 obese individuals and 288 controls, obese males with the G variant were shown to be associated with significantly increased risk of obesity and were found to be associated with higher BMI.

Association with Tendency to Regain Weight (Obesity):

In a study conducted on 3597 individuals, people with the G variant were shown to be associated with greater weight regain.

In another study that analyzed 16 gene polymorphisms associated with weight maintenance, people with the G variant were found to be associated with greater weight regain across treatment arms.

Association with MUFA Intake and Weight Gain:

In a study conducted on 1465 individuals, people with the G variant were found to have a lower BMI than people with the C variant in a diet rich in MUFA. In the same study, people with the G variant were shown to be associated with lower weight loss than people with the C variant when the total fat intake was high.

 

Genotype

rs1801282

Phenotype

Recommendations

CC

[Advantage] Likely to have lower risk of obesity

[Advantage] Less likely to regain weight after ending a hypocaloric diet

[Limitation] More likely to have a higher BMI on high MUFA intake

  • Consciously stick to an appropriate exercise regime, since the risk of weight regain is higher
  • Alternate between exercise routines like a regular gym workout to a Zumba class, variety could help stay motivated
  • A diet rich in MUFA could help in better weight management, while MUFA rich foods are also heart healthy
  • Some MUFA rich food sources are Olive oil, avocado, olives, almonds and peanuts
CG

Moderate risk of weight regain

GG

[Limitation] Likely to have higher risk of obesity

[Limitation] More likely to regain weight after ending a hypocaloric diet

[Advantage] Less likely to have a higher BMI on high MUFA intake

[Advantage] Less likely to have a higher BMI on high MUFA intake

  • It is important to include sufficient physical activity in your daily routine to maintain an ideal weight and lower the risk for diseases
  • Include MUFA rich food sources in the diet to improve heart health and increase physical activity to lower risk of weight gain
  • Some MUFA rich food sources are Olive oil, avocado, olives, almonds and peanuts

References:

  1. https://www.ncbi.nlm.nih.gov/pubmed/19733160?dopt=Abstract
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951915/
  3. https://www.ncbi.nlm.nih.gov/pubmed/22102511

Find out which variation of the gene you carry and more at www.xcode.in

“Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”

Amrita Surendranath
Amrita Surendranath
Amrita has a Masters in Human Genetics which fuelled her passion for genes and their diktats. She loves converting genetic research into exciting scientific news with a punch. 10 years on, her interesting insights have covered a range of topics that include cancer, diabetes, nutrition, fitness and more. A pulse on what’s interesting aids in decoding laboratory data into useful science that could empower people into molding healthier lifestyles.