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Know Your Genes: SGK1 “Salt Sensitivity 2 Gene”

The Serum and Glucocorticoid regulated kinase 1 (SGK1) gene is associated with the synthesis of serum and glucocorticoid regulated kinase 1, an enzyme which is associated with stress response. This kinase is also known to be associated with renal sodium retention. Increase in SGK1 is shown to be associated with increased sodium reabsorption and increase in blood pressure.

Our ancestors who lived between 2 million and 10,000 years ago were hunters and consumed less than 1g/day of salt from the animals and fruits and vegetables that they ate. Salt began to be used extensively when its properties associated with food preservation was discovered. Currently, salt intake is as high as 10 mg/day, which is shown to be associated with an increase in blood pressure and risk for cardiovascular disease.

Association with Salt Sensitivity:

In a study, people with the C variant were shown to be associated with higher diastolic blood pressure on high salt intake than people with the T variant.

 

Genotype

Phenotype

Recommendations

CC

[Limitation]Salt Sensitive

[Limitation]Greater increase in blood pressure on a high salt intake

  • People with a high blood pressure should practice mindful consumption of salt in the diet
  • Packaged soups, potato chips, sauce tend to have higher salt content
  • The adequate intake of salt in the diet is 1600mg which is equal to half a teaspoon of salt per day
CTIntermediate response to salt intake and blood pressure
TT

[Advantage]Normal Salt Sensitivity

[Advantage]No significant increase in blood pressure in response to high salt diet

  • Ensure optimum intake of salt in the diet

 

References:

    1. https://en.wikipedia.org/wiki/SGK1
    2. https://www.ncbi.nlm.nih.gov/pubmed/22648267
    3. https://www.ncbi.nlm.nih.gov/pubmed/24878720

 

Find out which variation of the gene you carry and more at www.xcode.in

“Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”

Amrita Surendranath
Amrita Surendranath
Amrita has a Masters in Human Genetics which fuelled her passion for genes and their diktats. She loves converting genetic research into exciting scientific news with a punch. 10 years on, her interesting insights have covered a range of topics that include cancer, diabetes, nutrition, fitness and more. A pulse on what’s interesting aids in decoding laboratory data into useful science that could empower people into molding healthier lifestyles.