Vitamin A is important for good vision, healthy eyes, healthy skin, and to fight infections.
Yet, it cannot be synthesized by the body.
Therefore, it becomes an essential nutrient that needs to be included in the diet.
Conversion of beta carotene to vitamin A is an important metabolic pathway which is genetically influenced.
Vitamin A refers to the interconvertible compounds retinal and retinol.
Both these can be converted into various other metabolites that are functionally important.
The transformation into these metabolites is irreversible.
Retinoic acid is one such metabolite.
Foods like milk, liver, fish oil, and eggs contain preformed vitamin A.
Beta carotene found in carrots and green leafy vegetables can be converted in the body into vitamin A, an important source for vegetarians.
Beta carotene is an ideal provitamin A carotenoid, and it needs to be converted into active vitamin A in the body.
Carotenoids are found in plants, and they are responsible for the distinct colors that some fruits and vegetables boast of.
Carrots get their orange color because of beta carotene.
According to the National Institute of Health, the following are the recommended units for the daily intake of beta carotene:
Once it is consumed, beta carotene is converted into vitamin A, which is then utilized by the body for various functions.
It is estimated that nearly 50% of vitamin A in a diet is due to beta carotene and other such carotenoids.
The major organs that are associated with beta carotene conversion are the liver and the intestines.
The liver is associated with storing significant proportion of retinoid.
There are two enzymes associated with beta carotene conversion to vitamin A, including:
Converting beta carotene to vitamin A is extremely variable with the estimated number of low responders to dietary beta carotene as high as 45%.
Genetic variants in the BCMO1 gene are associated with the conversion of beta carotene into retinol.
Check your Ancestry DNA or 23andMe raw data results for SNP rs7501331 that you carry[table “64” not found /]
Check your Ancestry DNA or 23andMe raw data results for SNP rs12934922 that you variants[table “65” not found /]
Enzyme activity based on genetic variant carried
A study by researchers from Newcastle University showed that individuals who carry the T allele of rs7501331 have a 32% reduction in enzyme activity while individuals who carried T allele for both rs7501331 and rs12934922 had a 69% reduction in enzyme activity.
A more recent study by researchers from the same university showed that apart from these two genetic variants in the BCM01 gene, there were other variants that had an influence on enzyme activity.
Other variants of interest are rs11645428, rs6420424, and rs6564851.
Vitamin A is important for vision and is used in the treatment of cataracts and age-related macular degeneration.
It is also important for the skin and immune system.
Vitamin A deficiency is major public health across the world. Each year, approximately 250,000–300,000 vitamin A-deficient children become, and half of them have been reported to die within a year after getting blind.
The following are some of the symptoms of vitamin A deficiency:
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Beta carotene is considered pre-vitamin, but it also is known to have certain benefits.
Each carrot is known to contain about 10 - 50 mg of beta carotene, apart from other nutrients.
The following are some of the foods rich in beta carotene[table “66” not found /]
Excess of retinoids is known to lead to teratogenic effects.
High levels of beta carotene are known to increase the risk for certain types of cancers.
One study found that there was an increased risk of lung cancer after β-carotene supplementation among smokers and people who drank more than 11 g ethanol/d.
High levels of beta carotene can affect the skin and lead to a condition known as carotenodermia.
The soles of the feet and the palms turn yellow.
Too little beta carotene or too much both have their share of risk, which makes genetic testing for vitamin A needs important.
How well your body converts beta carotene into retinol or vitamin A will help you identify the amount of beta carotene that should be consumed, from the diet or as a supplement.
Does your 23andme, Ancestry DNA, FTDNA DNA raw data have vitamin A information?
|CHIP Version||Vitamin A SNPs|
|23andMe (Use your 23andme raw data to know your DRD2 Variant)|
|V5 23andme (current chip)||Present|
|AncestryDNA (Use your ancestry DNA raw data to know your DRD2 Variant)|
|v1 ancestry DNA||Present|
|V2 ancestry DNA (current chip)||Present|
|Family Tree DNA (Use your FTDNA raw data to know your DRD2 Variant)|
|OmniExpress microarray chip||Present|