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1. How to read your Promethease report?

To read your Promethease review report you will need to ensure that you are accustomed to some of the terms that are found in their report like magnitude and repute. It is difficult to sift through thousands of pages in your report. Once you organize the pages as per your unique needs it becomes a relatively easy task to. 

2. What is Promethease?

Promethease allows users to analyze their genetic data and compare personal genomics results against the SNPedia database. SNPedia is a wiki-styled genetic data repository. 

Though popular, it is often criticized for being too technical and difficult to read. You can take a look at Promethease's sample report here.

Promethease is a do-it-yourself (DIY) tool for health genetic information from 23andMe raw data. It is a third party online tool that provides consumers information about their genetic variants and how they affect your health. After 23andme FDA ban on providing health reports, people started using tools like Promethease to get more information from their DNA raw data, other than just locating distant cousins. Though Promethease is a good tool built on a repository like SNPedia there are a number of factors to consider before you decide to upload your raw data to Promethease. Promethease is popular as a low-cost offering, but it’s also very technical and disease-centric. There are many alternatives to Promethease to analyze your 23andme raw data, that are easy to follow and understand. Below we present a feature by feature comparison between Promethease and Xcode Life Sciences.

3. How did Promethease gain popularity?

Promethease was one of the early companies to offer DNA raw data analysis based on 23andMe, Ancestry DNA raw data. 

What is DNA Raw Data?

A DNA raw data is a file that contains information about your genetic variants. These are called single nucleotide polymorphisms or SNPs and account for the differences in different traits like eye and hair color, height, and skin pigmentation across individuals. Your ancestry DNA raw data is a lab-generated text file. It is usually in the following two formats

The whole-genome files have a size of 80-90 GB (30x). All the top consumer genetic testing companies like 23andMe, AncestryDNA, Family Tree DNA enable their customers to [download their raw data](https://www.xcode.life/23andme-raw-data/download-23andme-dna-raw-data-third-3rd-party-tool) directly from the website or request a download. 

The raw data from different ancestry DNA testing companies have different numbers of genetic markers depending on the microarray chip used. For example, the 23andMe raw data has around 650,000 SNPs in its v5 chip and AncestryDNA has around 700,000 SNPs

When the FDA (briefly) banned 23andMe from providing health reports, Promethease was the only alternative and gained popularity because of its free service and low turnaround time.

Promethease is criticized for its user-unfriendly interface based on several user reviews. Some well-known competitors for this tool are Xcode Life, Codegen, Interpretive, Nutrahacker, and GEDMatch.

Update: In 2019, MyHeritage Acquired Promethease and SNPedia.

MyHeritage offered Promethease free of charge through the end of 2019 and continues to maintain SNPedia as a free resource for academic and non-profit users. The raw data of Non-European users has been shifted to MyHeritage into new accounts created for them. However, users retain ownership of their DNA raw data file and are free to delete it from MyHeritage's server.

4. How long does it take to get my Promethease reports?

Promethease takes approximately 20 minutes to generate health report from your raw data.

5. What does Promethease provide?

Promethease offers health reports based on 23andme, Ancestry DNA, Family Tree DNA, and other ancestry raw DNA data providers for a price of $12. Once you upload your DNA raw data, you will get your report in about 20 minutes.

Earlier, the reports were offered free or at a discount. So many users tried them due to the free/low-cost aspect and the high accuracy that the vastness of their content seemed to imply. However, the reports left individuals more confused than clear. 

So if you have a Promethease report that you still cannot make heads or tails of, read on.

6. What exactly do you get to know from a Promethease report?

Promethease is a wiki-style collection of peer-curated genetic information in contrast to expert-curated reports like Xcode Life's reports. You can search genes/variants/diseases as you would on Wikipedia. The results are pages of information. This is great for people who have degrees in genetics and want to learn about all the diseases they can get.

However, if you want organized information that you can use in specific aspects of your daily life, such as Nutrition, Fitness, or Ancestry, to enhance your health and wellbeing, then you may not find the Promethease reports all that helpful. Promethease's emphasis seems to be largely on the different diseases that one can get.

7. How to read my Promethease report?

Once you transfer your DNA raw data to Promethease, you will get a lengthy report. Though it may look like a massive report on the face of it, the amount of potentially useful information in the Promethease report is quite limited. Understanding and interpreting this report is a challenge. 

Let's break it down:

The total number of entries in a typical Promethease report = Approximately 25,000

Number of entries

The "Summary" component of the Promethease report is where the information pertaining to your genotype is given. This column, for the vast majority of the entries, has information that will not be useful to most people. It contains many terms that carry no useful information for the regular user.

The number of entries remaining after removing empty entries (no annotation) and terms such as "common in ClinVar," "common on affy axiom," "none," and "complete genomics,"," is 1482.

On further removal of more such terms (normal, common, etc.), you will be left with ~800 entries.

> So, only about 800 entries out of 25,000 (~ 3%) are potentially informative entries in the Promethease report.

8. Will getting the health test from 23andme give me better results?

A lot of people think that getting the additional health report from 23andme will help them get better results. That is not true! Whether you order the Health report or the Ancestry report from 23andme, the raw data you receive is the same!

9. How does Promethease work?

This third party DNA raw data analysis tool, is a literature retrieval system from SNPedia which is a Wikipedia style repository where people can add information. It is not a systematic risk assessment tool. For example, for Alzheimer’s disease (AD), you will not get a summary of your risk for developing AD. Instead, you will get a list of scientific literature that is available that indicates or does not indicate your risk for AD for a specific variant. For a particular disease or trait, if there are 15 articles that report on that particular DNA location, based on your SNPs 2 information sources might indicate an increased risk, 5 might be neutral, and 3 towards the lower side. Promethease does not summarise these for you. Rather it returns all these 10 articles and makes you do the interpreting yourself. This is the major reason why many individuals are alarmed and confused by their Promethease report.

10. How accurate is Promethease?

The vast majority of human traits are polygenic, meaning, several genes contribute towards that trait. Even if one carries a disease variant, they may also be carrying variants that reduce the risk of disease. Even in the case of Monogenic conditions- where one single gene leads to disease, scientist have found individuals carrying these deadly mutations but apparently healthy with no sign of disease. In a majority of the cases, the genetic risk is a small contributor towards the overall risk of that disease/condition. So, one must consider all of these things in interpreting their report. 

11. Where does Promethease get all its information?

Promethease only relies on SNPedia. Several other notable and high scientific authority tools are left out from the Promethease reports.

12. How do I filter through the Promethease report?

It is impractical to sift through the dump of information that you get (anticipate about 48,000 rows of data). The tool is equipped with different kinds of filters aimed at assisting you. Some of them are gene names, haplogroup names, diseases, drug names (referred to as “medicines”), medical conditions, names of genes and race.

13. What is magnitude in Promethease?

Magnitude is a subjective parameter that measures the interest level of the information. Here is the table partially resourced from the SNPedia website that describes what each numerical value indicates.

A-CD-FG-HI-NO-Z
3 beta-Hydroxysteroid dehydrogenase deficiencyDeafness, autosomal recessive 77Glucose-6-phosphate dehydrogenase (G6PD) deficiencyInclusion Body Myopathy 2Ornithine aminotransferase deficiency
3-Phosphoglycerate Dehydrogenase DeficiencyDeficiency of acetyl-CoA acetyltransferaseGalactosylceramide beta-galactosidase deficiencyInfantile Sialic acid storage disease; Salla diseaseOrnithine carbamoyltransferase deficiency
AbetalipoproteinaemiaDeficiency of alpha-mannosidaseGaucher diseaseIsovaleryl-CoA dehydrogenase deficiencyPartial adenosine deaminase deficiency
Achondrogenesis, type IB; Multiple epiphyseal dysplasia type 4; Atelosteogenesis type II; Diastrophic dysplasiaDeficiency of galactokinaseGitelman SyndromeJoubert Syndrome 2 / Meckel Syndrome 2Pendred syndrome
AchromatopsiaDeficiency of guanidinoacetate methyltransferaseGlutaric acidemia type 1Joubert syndrome 28Peroxisomal acyl-CoA oxidase deficiency
Acute infantile liver failure due to synthesis defect of mtDNA-encoded proteinsDeficiency of hydroxymethylglutaryl-CoA lyaseGlutaric acidemia type 2AJoubert syndrome 5Phenylketonuria
Acyl-CoA dehydrogenase family, member 9 deficiencyDeficiency of steroid 11-beta-monooxygenaseGlutaric acidemia type 2CJoubert syndrome 7Phosphoribosylpyrophosphate synthetase superactivity
AdrenoleukodystrophyDeficiency of UDPglucose-hexose-1-phosphate uridylyltransferaseGlycine encephalopathy (AMT-related)Junctional epidermolysis bullosa (LAMA3 related)Polyglandular autoimmune syndrome, type 1
Adult polyglucosan body neuropathyDihydrolipoamide dehydrogenase deficiencyGlycine encephalopathy (GLDC-related)Junctional epidermolysis bullosa (LAMB3 related)Polymicrogyria
Aicardi Goutieres syndrome 5Duchenne muscular dystrophyGlycogen storage disease due to glucose-6-phosphatase deficiency type IAJunctional epidermolysis bullosa (LAMC2 related)Pontocerebellar hypoplasia type 1A
Alpha thalassemia-X-linked intellectual disability syndromeDyskeratosis congenita, autosomal recessive, 5Glycogen storage disease type 1BJuvenile retinoschisisPontocerebellar hypoplasia type 2D
Alport Syndrome (COL4A3-related)Dystrophic epidermolysis bullosaGlycogen storage disease type 2Lamellar Ichthyosis, Type 1Pontocerebellar hypoplasia type 6
Alport Syndrome (COL4A4-related)Ehlers-Danlos syndrome dermatosparaxis typeGlycogen storage disease type 3Laminin alpha 2-related dystrophyPrimary carnitine deficiency
Alport Syndrome, X-linked (COL4A5-related)Ellis-van Creveld syndrome (EVC-related)Glycogen storage disease type 4Laryngo-onycho-cutaneous syndromePrimary Ciliary Dyskinesia (DNAH11-related)
Alstrom syndromeEllis-van Creveld syndrome (EVC2-related)Glycogen storage disease type 5Leber congenital amaurosis 10Primary Ciliary Dyskinesia (DNAH5-related)
Anauxetic dysplasia; Cartilage-hair hypoplasia; Metaphyseal dysplasia without hypotrichosisEmery-Dreifuss muscular dystrophy, X-linkedGlycogen storage disease type 7Leber congenital amaurosis 13Primary Ciliary Dyskinesia (DNAI1-related)
Andermann SyndromeEnhanced s-cone syndromeGRACILE syndrome/ BCS1L-related disordersLeber congenital amaurosis 2Primary Ciliary Dyskinesia (DNAI2-related)
Arginase deficiencyEthylmalonic encephalopathyHemochromatosis type 2ALeber congenital amaurosis 5Primary hyperoxaluria type I
Argininosuccinate lyase deficiencyFabry diseaseHemochromatosis type 3Leber congenital amaurosis 8Primary hyperoxaluria type II
Aromatase deficiencyFamilial dysautonomiaHereditary acrodermatitis enteropathicaLeigh syndrome, French Canadian typePrimary hyperoxaluria type III
Arthrogryposis, mental retardation, and seizuresFamilial hypercholesterolemia (LDLR related)Hereditary factor IX deficiency diseaseLethal congenital contracture syndromeProgressive familial intrahepatic cholestasis 2
Arts syndromeFamilial hypercholesterolemia (LDLRAP1 related)Hereditary fructosuriaLeukoencephalopathy with vanishing white matterPropionic acidemia (PCCA related)
Asparagine synthetase deficiencyFamilial Hyperinsulinism, ABCC8-RelatedHereditary insensitivity to pain with anhidrosisLimb-girdle muscular dystrophy type 2APropionic acidemia (PCCB related)
AspartylglucosaminuriaFamilial isolated deficiency of vitamin EHereditary spastic paraplegia 15Limb-girdle muscular dystrophy type 2BPyknodysostosis
Ataxia-telangiectasia syndromeFanconi anemia type AHermansky-Pudlak syndrome type 1Limb-girdle muscular dystrophy type 2CPyruvate carboxylase deficiency
Autosomal recessive osteopetrosis 1Fanconi anemia type CHermansky-Pudlak syndrome type 3Limb-girdle muscular dystrophy type 2DPyruvate dehydrogenase E1-alpha deficiency
Autosomal recessive polycystic kidney diseaseFanconi anemia type GHolocarboxylase synthetase deficiencyLimb-girdle muscular dystrophy type 2EPyruvate dehydrogenase E1-beta deficiency
Bardet-Biedl syndrome 1Fetal akinesia deformation sequenceHomocystinuria (CBS related)Limb-girdle muscular dystrophy type 2FRenal tubular acidosis with progressive nerve deafness
Bardet-Biedl syndrome 10Finnish congenital nephrotic syndromeHomocystinuria due to MTHFR deficiencyLong-chain 3-hydroxyacyl-CoA dehydrogenase deficiencyRetinitis pigmentosa 20
Bardet-Biedl syndrome 12Fragile X syndromeHomocystinuria, cobalamin E typeLysinuric protein intoleranceRetinitis pigmentosa 25
Bardet-Biedl syndrome 13Fukuyama congenital muscular dystrophyHydrolethalus syndromeLysosomal acid lipase deficiencyRetinitis pigmentosa 26
Bardet-Biedl syndrome 14Fumarase deficiencyHyperlipoproteinemia, type IMaple syrup urine disease type 1ARetinitis pigmentosa 28
Bardet-Biedl syndrome 2Hyperornithinemia-hyperammonemia-homocitrullinuria syndromeMaple syrup urine disease type 1BRetinitis pigmentosa 59
Bare lymphocyte syndrome 2Hypohidrotic X-linked ectodermal dysplasiaMaple syrup urine disease type 2Retinitis pigmentosa 73
Bartter disease type 4aHypophosphatasiaMeckel-Gruber syndromeRetinitis pigmentosa 76
BH4-deficient hyperphenylalaninemia AMeckel syndrome type 1Rhizomelic chondrodysplasia punctata type 1/ Refsum disease (PEX7-related)
Bifunctional peroxisomal enzyme deficiencyMeckel syndrome type 4Rhizomelic chondrodysplasia punctata type 3
Bloom syndromeMeckel syndrome, type 5Roberts-SC phocomelia syndrome
Canavan DiseaseMedium-chain acyl-coenzyme A dehydrogenase deficiencySandhoff disease
Carnitine palmitoyltransferase I deficiencyMegalencephalic leukoencephalopathy with subcortical cysts 1Schimke immuno-osseous dysplasia
Carnitine palmitoyltransferase II deficiencyMenkes kinky-hair syndromeSegawa syndrome
Carpenter syndrome 1Metachromatic leukodystrophy (ARSA related)Senior-Loken syndrome 6
Cerebrotendinous xanthomatosisMetachromatic leukodystrophy due toSevere combined immunodeficiency (RAG2-related)
Charcot-Marie-Tooth disease type 4Dsaposin-b deficiencySevere combined immunodeficiency due to ADA deficiency
Charcot-Marie-Tooth disease, X-linkedMethylmalonic acidemia (MMAA related)Severe combined immunodeficiency due to DCLRE1C deficiency
Charcot-Marie-Tooth Neuropathy XMethylmalonic acidemia (MMAB related)Severe combined immunodeficiency, X-linked
Charlevoix-Saguenay spastic ataxiaMethylmalonic Aciduria and Homocystinuria, Type cblCSevere congenital neutropenia 3
ChoreoacanthocytosisMethylmalonic Aciduria and Homocystinuria, Type cblDSevere congenital neutropenia 5, autosomal recessive
ChoroideremiaMicrocephaly, postnatal progressive, with seizures and brain atrophySevere X-linked myotubular myopathy
Chronic granulomatous disease (CYBA related)Microphthalmia /clinical anophthalmia (VSX2-related)Sjögren-Larsson syndrome
Chronic granulomatous disease, X-linkedMitochondrial complex I deficiency/ Leigh syndrome (NDUFAF5-related)Smith-Lemli-Opitz syndrome
Citrin deficiencyMitochondrial complex I deficiency/ Leigh syndrome (NDUFAF6-related)Spastic paraplegia 49, autosomal recessive
Citrullinemia type IMitochondrial DNA depletion syndrome 1 (MNGIE type)Spinal muscular atrophy
Cockayne syndrome type AMPV17-related mitochondrial DNA maintenance defectSpondylocostal dysostosis
Cockayne syndrome type BMucolipidosis type IISteel syndrome
Cohen syndromeMucolipidosis type III gammaStuve-Wiedemann Syndrome
Combined malonic and methylmalonic aciduriaMucolipidosis type IVTay-Sachs disease
Combined oxidative phosphorylation deficiency 1Mucopolysaccharidosis type I (Hurler syndrome)Tooth agenesis, selective, 4; Odonto-onycho-dermal dysplasia; Schopf-Schulz-Passarge syndrome
Combined oxidative phosphorylation deficiency 3Mucopolysaccharidosis type II (Hurler syndrome)Tyrosinemia type I
Combined Pituitary Hormone Deficiency-2Mucopolysaccharidosis type IIIATyrosinemia type II
Combined Pituitary Hormone Deficiency-3Mucopolysaccharidosis type IIIB (Sanfilippo B)Usher syndrome type 1B
Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiencyMucopolysaccharidosis type IIICUsher syndrome type 1C
Congenital adrenal hyperplasia due to 21-hydroxylase deficiencyMucopolysaccharidosis type IIIDUsher syndrome type 1D
Congenital Adrenal HyperplasiaMucopolysaccharidosis type IVB (Morquio B syndrome)/ GM1 gangliosidosisUsher syndrome type 1F
Congenital amegakaryocytic thrombocytopeniaMucopolysaccharidosis type IXUsher syndrome type 2A
Congenital bilateral aplasia of vas deferens from CFTR mutationMucopolysaccharidosis type VIUsher syndrome type 3A
Congenital disorder of glycosylation type 1AMultiple sulfatase deficiencyVery long-chain acyl-CoA dehydrogenase deficiency
Congenital disorder of glycosylation type 1BMuscular dystrophy-dystroglycanopathy, FKTN-relatedWalker-Warburg congenital muscular dystrophy
Congenital disorder of glycosylation type 1CMyopathy, lactic acidosis, and sideroblastic anemia 1Werdnig-Hoffmann disease
Congenital hyperammonemia, type IN-acetylglutamate Synthase DeficiencyWilson disease
Congenital HyperinsulinismNemaline myopathy 2Xeroderma pigmentosum group A
Congenital muscular dystrophy-dystroglycanopathyNephrogenic diabetes insipidusXeroderma pigmentosum, group C
Congenital myasthenic syndromeNephrotic syndrome, idiopathic, steroid-resistantZellweger spectrum disorder (PEX1-related)
Congenital myasthenic syndrome (CHRNE)Neuronal ceroid lipofuscinosis 1Zellweger spectrum disorder (PEX10-related)
Corneal dystrophy-perceptive deafness syndromeNeuronal ceroid lipofuscinosis 2Zellweger spectrum disorder (PEX12-related)
Corneal endothelial dystrophyNeuronal ceroid lipofuscinosis 3Zellweger spectrum disorder (PEX2-related)
Corticosterone Methyloxidase DeficiencyNeuronal ceroid lipofuscinosis 5Zellweger spectrum disorder (PEX6-related)
Costeff Syndrome (3-Methylglutaconic Aciduria, Type 3)Neuronal ceroid lipofuscinosis 6
Creatine transporter deficiencyNeuronal ceroid lipofuscinosis 7
Cystic fibrosisNeuronal ceroid lipofuscinosis 8
CystinosisNiemann-Pick disease type C1
Niemann-Pick disease type C2
Niemann-Pick Disease, Types A/B
Nijmegen breakage syndrome
Nonsyndromic hearing loss and deafness

14. What is Promethease repute?

Good repute: The variation has a positive influence on you.

Not set: There is no verified information on the nature of the variation.

Bad repute: The variation has a negative influence on you.

According to the SNPedia website, it is better to leave the repute as “Not Set” as all genotypes have a little of both the “good” and “bad” repute.

15. What are ClinVar diseases?

This option allows you to see only the SNPs present in ClinVar. ClinVar is a freely accessible public archive of information on genetic variations specifically with clinical implications. It is maintained by the National Institute of Health (NIH). When you filter using this option you will find all the medical conditions that have been formally labeled by ClinVar.

16. How is Xcode Life different from Promethease?

How is Xcode Life Report different from the Promethease report?

Xcode Life puts together expert-curated references of variant annotations from several large databases and leading scientific journals. 

The information is then organized systematically into topical reports such as Nutrition, Health, Fitness, Skin, Allergy, Ancestry, etc. 

Each report is further organized into traits, which provide actionable insights into your genetic type along with specific recommendations. Xcode reports are easily readable, understandable, and implementable. 

The core philosophy of Xcode reports, in contrast to Promethease's voluminous coverage of diseases, is to empower the user with actionable genetic information that they can use to enhance health and wellbeing. Each report is reasonably priced at around $20; additionally, there are package discounts if the user buys multiple reports together.

If you are not looking for anything specific and just want to satisfy your curiosity, then Promethease may be the way to go. Even then, it is very likely that you will be left scratching your head with a vast load of information that you can't make sense of. But, if you want specific, organized, and actionable insights from your genetic data about your health and wellbeing, then you certainly must try the Xcode Health reports.

Drug (A-C)GeneGuidelinesDrug (D-N)GeneGuidelinesDrug (O-Z)GeneGuidelines
(R)-methadone;(S)-EDDP;methadoneUGT2B7PGXDabigatranCES1PGXo-desmethyltramadol;tramadolRFPL4BPGX
3,4-methylenedioxymethamphetamineSLC6A2PGXdaclatasvir;peginterferon alfa-2a;peginterferon alfa-2b;ribavirinIFNL3;IFNL4PGXolanzapineABCB1PGX
abacavirHLA-BCPICdalcetrapibADCY9PGXolanzapineBDNFPGX
abacavirHLA-BDPWGdapsoneHLA-DRB1PGXolanzapineGIPRPGX
abacavirHLA-BFDAdaptomycinABCB1PGXolanzapine;perphenazineRGS4PGX
abacavirLST1;LTA;LTBPGXdarifenacinCYP2D6FDAolanzapine;risperidoneDRD2PGX
abiraterone;prednisoloneDSE;TSPYL1PGXdasatinib;imatinibABCG2PGXolanzapine;risperidoneHTR2APGX
ABT-751UGT1A4PGXdasatinib;imatinib;nilotinibABCG2PGXomeprazoleCYP2C19CPIC
acamprosateGRIN2BPGXdaunorubicinNOS3PGXomeprazoleCYP2C19DPWG
Ace Inhibitors;PlainXPNPEP2PGXdebrisoquineCYP2D6PGXomeprazoleCYP2C19FDA
Ace Inhibitors;Plain;Angiotensin II Antagonists;Beta Blocking Agents;digoxin;diuretics;spironolactoneADRB2PGXdeferasiroxABCG2PGXomeprazoleABCB1PGX
Ace Inhibitors;Plain;Angiotensin II Antagonists;Beta Blocking Agents;digoxin;diuretics;spironolactoneNOS3PGXdeferasiroxUGT1A3PGXondansetronCYP2D6CPIC
acenocoumarolCYP4F2PGXdeferiproneUGT1A6PGXondansetronABCB1PGX
acenocoumarolVKORC1PGXdeleobuvir;faldaprevirIFNL3;IFNL4PGXOpioid anesthetics;Other general anesthetics;volatile anestheticsOPRM1PGX
acenocoumarol;phenprocoumonVKORC1PGXdesfluraneCACNA1SPGXopioidsOPRM1PGX
acenocoumarol;warfarinAPOEPGXdesflurane;enflurane;halothane;isoflurane;methoxyflurane;sevoflurane;succinylcholineRYR1PGXOpium alkaloids and derivativesCHRNA3PGX
acetaldehydeALDH2PGXdesipramineCYP2D6CPICOpium alkaloids and derivativesCHRNA5PGX
acetaldehydePGM1PGXdesipramineCYP2D6FDAoseltamivirABCB1PGX
acetaminophenTRPV1PGXdesipramineMC1RPGXoxaliplatinABCB1PGX
acetaminophenUGT1APGXdesloratadineHRH1PGXoxazepamUGT2B15PGX
acetaminophen;aspirin;diclofenac;propionic acid derivatives;PyrazolonesPLA2G4APGXdesloratadine;mizolastineFCER1APGXoxcarbazepineHLA-BCPIC
acetaminophen;ibuprofen;loxoprofen;salicylamidePGXdeutetrabenazineCYP2D6FDAoxcarbazepineHLA-BFDA
acetaminophen;tramadolOPRM1PGXdexamethasoneSERPINE1PGXoxcarbazepineABCB1PGX
acetylcholineACEPGXdexamethasone;doxorubicin;vincristineABCB1PGXoxycodoneCOMTPGX
acetylcysteineTOLLIPPGXdexamethasone;lenalidomideABCB1PGXpaclitaxelABCB1PGX
adalimumabATG16L1PGXdexlansoprazoleCYP2C19CPICpaclitaxel;Platinum compoundsCASP7PGX
adalimumabHFEPGXdexlansoprazoleCYP2C19FDApaliperidoneMC4RPGX
adalimumab;certolizumab pegol;etanercept;glucocorticoids;infliximab;methotrexateKLRD1PGXdexmedetomidineADRA2APGXpantoprazoleCYP2C19CPIC
adalimumab;etanercept;infliximabFCGR3APGXdextroamphetamine;methylphenidateDRD1PGXpantoprazoleCYP2C19DPWG
adalimumab;etanercept;infliximab;Tumor necrosis factor alpha (TNF-alpha) inhibitorsTRAF1PGXdiazepamCYP2C19FDApantoprazoleCYP2C19FDA
adalimumab;infliximabFCGR2APGXdicloxacillinABCB1PGXpantoprazoleABCB1PGX
adefovir dipivoxilSLC22A6PGXdidanosineNT5C2PGXparoxetineCYP2D6CPIC
adefovir dipivoxil;cidofovir;tenofovirSLC22A6PGXdifluorodeoxyuridineCDAPGXparoxetineCYP2D6DPWG
adrenergics, inhalantsPGXdigoxinABCB1PGXparoxetineCYP2D6FDA
agomelatineABCB1PGXDihydropyridine derivativesNOS1APPGXparoxetineCYP1A2PGX
alemtuzumab;chlorambucil;cyclophosphamide;fludarabine;prednisone;rituximab;vincristineCXCL12PGXdiltiazemPLCD3PGXparoxetineHTR1APGX
alendronateVDRPGXdimethyl fumarateGSTP1PGXpazopanibHLA-BFDA
alfentanilOPRM1PGXDipeptidyl peptidase 4 (DPP-4) inhibitorsCDKAL1PGXpazopanibUGT1A1FDA
Alkylating AgentsEGFRPGXdirect acting antiviralsIFNL4PGXpeginterferon alfa-2aIFNL3;IFNL4PGX
Alkylating Agents;cisplatinESR1PGXdisopyramideKCNH2PGXpeginterferon alfa-2a;peginterferon alfa-2bIFNL3;IFNL4PGX
allopurinolHLA-BCPICdisulfiramSLC6A3PGXpeginterferon alfa-2a;peginterferon alfa-2b;ribavirinIFNL3PGX
allopurinolHLA-BFDAdiureticsPDE4DPGXpeginterferon alfa-2a;peginterferon alfa-2b;ribavirinIFNL3;IFNL4PGX
allopurinolABCG2PGXdiuretics;hydrochlorothiazideNEDD4LPGXpeginterferon alfa-2a;peginterferon alfa-2b;ribavirinIFNL4PGX
allopurinolCYCSP5PGXdobutamineADRB1PGXpeginterferon alfa-2a;peginterferon alfa-2b;ribavirin;simeprevirIFNL4PGX
allopurinol;febuxostatAOX1PGXdocetaxelCYP3A4PGXpeginterferon alfa-2a;peginterferon alfa-2b;ribavirin;telaprevirIFNL3PGX
allopurinol;febuxostatUGT1A1;UGT1A10;UGT1A3;UGT1A4;UGT1A5;UGT1A6;UGT1A7;UGT1A8;UGT1A9PGXdocetaxelSLCO1B3PGXpeginterferon alfa-2a;peginterferon alfa-2b;ribavirin;telaprevirIFNL3;IFNL4PGX
alprazolamCYP3A;CYP3A4PGXdocetaxelVEGFAPGXpeginterferon alfa-2a;ribavirinSCARB1PGX
amantadine;Anticholinergics;Dopamine agonists;levodopa;selegilineSLC22A1PGXdocetaxel;doxorubicinAKR1C3PGXpeginterferon alfa-2a;ribavirinVDRPGX
amifampridineNAT2FDAdocetaxel;epirubicinMDM4PGXpeginterferon alfa-2bHLA-DPA1PGX
amifampridine phosphateNAT2FDAdocetaxel;FEC100;gemcitabine;trastuzumab;zoledronatePPCDCPGXpeginterferon alfa-2b;protease inhibitors;ribavirinSLC28A2PGX
amiloride;spironolactoneCYP4A11PGXdocetaxel;gemcitabine;paclitaxel;Platinum compounds;vinorelbineCASP7PGXpeginterferon alfa-2b;ribavirinITPAPGX
aminoglycoside antibacterialsMT-RNR1PGXdocetaxel;thalidomideCHST3PGXpemetrexedGGHPGX
amiodaroneNOS1APPGXdolasetron;granisetronNOS1APPGXpemetrexedMTHFRPGX
amiodarone;Antibiotics;antipsychotics;diuretics;quinidine;sotalolKCNE1PGXdolutegravirUGT1A1FDAperindoprilBDKRB1PGX
amisulprideMC4RPGXdolutegravirABCG2PGXperphenazineCYP2D6FDA
amisulpride;antipsychotics;olanzapine;quetiapine;risperidoneHTR1APGXdonepezilCYP2D6FDAPertussis vaccinesTLR4PGX
amisulpride;aripiprazole;clozapine;lithium;mirtazapine;olanzapine;paliperidone;quetiapine;risperidone;valproic acidSH2B1PGXdonepezilBCHEPGXphenazepamCYP2C19PGX
amitriptylineCYP2C19CPICdonepezilCHATPGXphenobarbitalABCB1PGX
amitriptylineCYP2D6CPICdonepezil;galantamine;rivastigmineCHATPGXphenobarbital;phenytoinMTHFRPGX
amitriptylineCYP2D6DPWGdonepezil;galantamine;rivastigmineCHRNA7PGXphenprocoumonVKORC1PGX
amitriptylineCYP2D6FDAdoxepinCYP2C19CPICphenytoinCYP2C9DPWG
amitriptyline;antidepressants;citalopram;fluvoxamine;paroxetine;sertraline;venlafaxineABCB1PGXdoxepinCYP2C19FDAphenytoinCFHR4PGX
amitriptyline;antidepressants;citalopram;paroxetine;venlafaxineABCB1PGXdoxepinCYP2D6CPICphenytoinSCN1APGX
amitriptyline;citalopram;fluoxetine;paroxetine;sertraline;venlafaxineABCB1PGXdoxepinCYP2D6DPWGphotodynamic therapyF13A1PGX
amitriptyline;citalopram;paroxetine;venlafaxineABCB1PGXdoxepinCYP2D6FDApimozideCYP2D6DPWG
amlodipineCYP3A4PGXdoxorubicinABCC1PGXpimozideCYP2D6FDA
amlodipine;chlorthalidoneNPPAPGXdoxorubicinCBR3PGXpioglitazoneADIPOQPGX
amlodipine;chlorthalidone;lisinoprilACEPGXdoxorubicin;doxorubicinolCBR1PGXpiroxicamCYP2C9CPIC
amlodipine;chlorthalidone;lisinoprilAGTPGXdoxorubicin;idarubicinCYBAPGXpiroxicamCYP2C9FDA
amodiaquineCYP2C8PGXdoxorubicin;methotrexate;prednisolone;vincristineABCB1PGXpitavastatinABCC2PGX
amodiaquine;pyrimethamine;sulfadoxineG6PDPGXdronabinolCYP2C9FDApitrakinraIL4RPGX
amoxapineCYP2D6FDADrug(s)GenePGXplatinumERCC5PGX
amoxicillin;clavulanateHLA-DQB1PGXDrugs For Treatment Of TuberculosisNAT2PGXPlatinum compoundsGSTP1PGX
amphetamineCYP2D6FDADrugs For Treatment Of Tuberculosis;isoniazidABCB1PGXPlatinum compoundsHSPA5PGX
amphetamineDRD2PGXDrugs For Treatment Of Tuberculosis;rifampinRIPOR2PGXPlatinum compoundsXRCC1PGX
amphetamine;cannabinoids;cocaine;opioidsKAT2BPGXDrugs used in alcohol dependenceGATA4PGXPlatinum compounds;radiotherapyPGX
amprenavirSLCO1B1PGXDrugs Used In DiabetesIRS1PGXPlatinum compounds;taxanesABCB1PGX
AnalgesicsKCNJ6PGXDrugs used in nicotine dependence;nicotineCHRNA3PGXpramipexoleDRD3PGX
Analgesics;Antiinflammatory agents, non-steroids;Ergot alkaloids;opioids;sumatriptanCOMTPGXDrugs used in nicotine dependence;nicotine;vareniclineCHRNA5PGXprasugrelCYP2C19PGX
Analgesics;Antiinflammatory agents, non-steroids;Ergot alkaloids;opioids;sumatriptanOPRM1PGXduloxetineNCAM1PGXpravastatinKIF6PGX
anastrozoleCYP19A1PGXduloxetineZNF385DPGXpravastatinSLCO1B1PGX
anastrozole;exemestaneMAP4K4PGXeculizumabC5PGXpravastatin;simvastatinHMGCRPGX
anastrozole;exemestane;letrozoleCYP19A1PGXeculizumabCR1PGXprednisone;tacrolimusABCB1PGX
anastrozole;letrozoleTNFRSF11BPGXefavirenzCYP2B6CPICpregabalinSLC7A5PGX
anastrozole;letrozoleTNFSF11PGXefavirenzCYP2B6DPWGprochlorperazineANKK1;DRD2PGX
angiotensin IIAGTR1PGXefavirenzCYP2B6FDApropafenoneCYP2D6DPWG
anthracyclines and related substancesCBR3PGXefavirenzCYP2B6PGXpropafenoneCYP2D6FDA
anthracyclines and related substancesHAS3PGXefavirenz;lopinavir;Nucleoside and nucleotide reverse transcriptase inhibitors;ritonavirPGXpropofolCYP2B6PGX
anthracyclines and related substances;cyclophosphamide;doxorubicin;epirubicin;fluorouracil;methotrexate;oxaliplatin;Platinum compoundsNOS3PGXefavirenz;nelfinavirABCB1PGXpropofol;remifentanilABCB1PGX
anthracyclines and related substances;taxanesABCB1PGXegfr inhibitorsEGFRPGXpropranololCYP2D6FDA
AntibioticsLGALS3PGXelagolixSLCO1B1FDApropranololADRB2PGX
antidepressantsHTR2APGXeliglustatCYP2D6DPWGprotriptylineCYP2D6FDA
antidepressantsSLC6A4PGXeliglustatCYP2D6FDAquetiapineCOMTPGX
antidepressants;antiepileptics;Beta Blocking Agents;calcium channel blockersACEPGXenalaprilPGXquetiapineMC4RPGX
antidepressants;antipsychotics;benzodiazepine derivatives;opioids;SympathomimeticsOPRM1PGXenalaprilACEPGXquinaprilAGTPGX
antidepressants;benzodiazepine derivatives;mirtazapine;Selective serotonin reuptake inhibitorsGALPGXenalapril;imidapril;lisinoprilBDKRB2PGXrabeprazoleCYP2C19FDA
antidepressants;citalopramCREB1;METTL21APGXendoxifenPGXradiotherapyCDK1PGX
antidepressants;citalopram;clomipramine;lithium;nefazodone;paroxetine;venlafaxineFKBP5PGXenfluraneCACNA1SPGXraloxifeneUGT1A8PGX
antidepressants;citalopram;escitalopram;fluoxetine;paroxetineTPH1PGXentacaponeCOMTPGXraltegravirUGT1A1FDA
antidepressants;citalopram;fluoxetineSERPINE1PGXEnzymesA2MPGXramiprilACEPGX
antidepressants;citalopram;fluvoxamine;paroxetine;sertraline;venlafaxineABCB1PGXephedrine;phenylephrineADRB2PGXranibizumabNRP1PGX
antidepressants;citalopram;paroxetineBDNFPGXepirubicin;fluorouracil;oxaliplatinNQO1PGXrasagilineDRD2PGX
antidepressants;desipramine;fluoxetineBDNFPGXerdafitinibCYP2C9FDAregadenosonAMPD1PGX
antidepressants;fluvoxamine;paroxetine;Selective serotonin reuptake inhibitors;sertralineHTR1APGXerlotinibEGFRPGXremifentanilCOMTPGX
antidepressants;mirtazapine;venlafaxineTPH2PGXerythromycinABCC2PGXremifentanil;sevofluraneABCB1PGX
antidepressants;Selective serotonin reuptake inhibitorsFKBP5PGXescitalopramCYP2C19CPICrepaglinideCYP2C8PGX
antidepressants;Selective serotonin reuptake inhibitors;venlafaxineGRIA3PGXescitalopramCYP2C19DPWGrepaglinideNEUROD1PGX
antiepilepticsABCB1PGXescitalopramCYP2C19FDArhodamine 123ABCB1PGX
antiepileptics;carbamazepineABCB1PGXescitalopramBMP5PGXrifampinNR1I2PGX
antiepileptics;carbamazepine;lamotrigine;oxcarbazepine;phenytoin;topiramateSCN2APGXescitalopramCYP1A2PGXrisperidoneCYP2D6DPWG
antiepileptics;carbamazepine;oxcarbazepineABCC2PGXescitalopram;nortriptylineBDNFPGXrisperidoneCYP2D6FDA
antiepileptics;carbamazepine;phenobarbital;phenytoin;valproic acidSCN2APGXesomeprazoleCYP2C19FDArisperidoneHTR2CPGX
AntihypertensivesATP2B1PGXesomeprazoleSTAT6PGXrisperidoneMC4RPGX
Antihypertensives And Diuretics In CombinationNOS3PGXestradiolPGXritodrineCACNA1CPGX
Antihypertensives;Antihypertensives And Diuretics In Combination;diureticsNOS3PGXetanerceptTNFPGXritonavirAPOC3PGX
Antihypertensives;Beta Blocking AgentsGRK5PGXethambutol;isoniazid;pyrazinamide;rifampinCYP2C9PGXrituximabFCGR3APGX
Antiinflammatory agents, non-steroidsCDKN2B-AS1PGXethanolADH1BPGXrivastigmineBCHEPGX
Antiinflammatory agents, non-steroidsPTGS1PGXethanolOPRM1PGXrocuroniumABCB1PGX
Antiinflammatory agents, non-steroids;aspirinPGXetoposideABCB1PGXrofecoxibPTGS2PGX
Antiinflammatory agents, non-steroids;celecoxib;diclofenacCYP2C9PGXetoposideSLIT1PGXrosiglitazonePAX4PGX
antineoplastic agentsSERPINA3PGXetravirineCYP2C19PGXrosuvastatinSLCO1B1FDA
antineoplastic agentsTP53PGXeverolimusPIK3R1PGXrosuvastatinABCG2PGX
antipsychoticsBDNFPGXeverolimusRPTORPGXrosuvastatinSLCO1B1PGX
antipsychoticsGRM3PGXexemestaneCYP19A1PGXsalbutamolADRB2PGX
antipsychotics;aripiprazole;bromperidol;chlorpromazine;clozapine;nemonapride;olanzapine;risperidoneDRD2PGXexemestane;letrozoleCYP19A1PGXsalbutamol;selective beta-2-adrenoreceptor agonistsCRHR2PGX
antipsychotics;aripiprazole;risperidoneANKK1PGXexemestane;letrozoleESR1PGXsalmeterolADRB2PGX
antipsychotics;chlorpromazine;fluphenazine;thioridazine;trifluoperazineCYP1A2PGXFarglitazar;glibenclamideSCNN1BPGXsalvianolic acid bNOS3PGX
antipsychotics;clozapine;olanzapineDRD2PGXfenofibrateAPOA5PGXselective beta-2-adrenoreceptor agonistsARG1PGX
antipsychotics;olanzapine;perphenazine;quetiapine;ziprasidoneRGS4PGXfenofibrateCRPPGXSelective serotonin reuptake inhibitorsHTR7PGX
antipsychotics;risperidoneLEPPGXfentanylABCB1PGXsertralineCYP2C19CPIC
antithymocyte globulinFCGR3APGXfentanylOPRM1PGXsertralineCYP2C19DPWG
Antithyroid PreparationsHLA-BPGXfentanyl;morphine;opioids;oxycodoneRHBDF2PGXsertralineGNB3;P3H3PGX
Antivirals for treatment of HIV infections, combinations;Drugs For Treatment Of TuberculosisABCB1PGXfentanyl;propofol;remifentanil;sevofluraneADRB2PGXsevofluraneCACNA1SPGX
Antivirals for treatment of HIV infections, combinations;ritonavirAPOEPGXfesoterodineCYP2D6FDAsibutramineGNB3PGX
apixabanABCG2PGXfexofenadineABCB1PGXsildenafilGNB3PGX
aripiprazoleCYP2D6DPWGfexofenadineSLCO2B1PGXsilibininABCB1PGX
aripiprazoleCYP2D6FDAflecainideCYP2D6DPWGsimvastatinSLCO1B1FDA
aripiprazoleDRD2PGXflecainideSCN4APGXsimvastatinHMGCRPGX
aripiprazole lauroxilCYP2D6FDAflecainide;mexiletineSCN4APGXsimvastatinSLCO1B1PGX
aripiprazole;clozapine;haloperidol;olanzapine;quetiapine;risperidoneFAAHPGXflecanideCYP2D6DPWGsimvastatin acidSLCO1B1PGX
aripiprazole;risperidoneDRD2PGXflibanserinCYP2C19FDAsiponimodCYP2C9FDA
artesunate;chlorproguanil;dapsoneG6PDPGXflucloxacillinNR1I2PGXsirolimusABCB1PGX
artesunate;primaquine;pyrimethamine;sulfadoxineG6PD;IKBKGPGXfluindioneVKORC1PGXsirolimus;temsirolimusNR1I2PGX
asparaginaseNFATC2PGXflunisolideTBXTPGXsitagliptin;vildagliptinGLP1RPGX
asparaginase;cyclophosphamide;cytarabine;daunorubicin;dexamethasone;doxorubicin;leucovorin;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristineGATA3PGXfluorouracilDPYDCPICSN-38UGT1A9PGX
asparaginase;cyclophosphamide;daunorubicin;prednisolone;vincristinePNPLA3PGXfluorouracilDPYDDPWGsofosbuvirIFNL3;IFNL4PGX
asparaginase;dexamethasone;methotrexatePYGLPGXfluorouracilDPYDFDAsofosbuvir;velpatasvir;voxilaprevirIFNL3;IFNL4PGX
aspirinPPARGPGXfluorouracilDPYDPGXsomatropin recombinantCOL1A1PGX
aspirin;Beta Blocking Agents;clopidogrel;hmg coa reductase inhibitorsNOS3PGXfluorouracil;FOLFIRI;FOLFOXTYMSPGXsorafenibKDRPGX
aspirin;clopidogrelITGA2PGXfluorouracil;FOLFOXTYMSPGXspironolactoneACEPGX
aspirin;clopidogrel;prasugrelPEAR1PGXfluorouracil;irinotecan;leucovorinABCG1PGXstavudineSAMHD1PGX
aspirin;prasugrelNTRK1;PEAR1PGXfluorouracil;irinotecan;leucovorinABCG2PGXsuccinylcholineCACNA1SPGX
atalurenCFTRPGXfluorouracil;leucovorin;oxaliplatinMTHFRPGXsuccinylcholineBCHEFDA
atazanavirUGT1A1CPICfluorouracil;oxaliplatinPARD3BPGXsuccinylcholine;volatile anestheticsRYR1PGX
atazanavirUGT1A2CPICfluorouracil;Platinum compounds;radiotherapyTMEM167A;XRCC4PGXsufentanilCOMTPGX
atazanavirUGT1A3CPICfluorouracil;Platinum compounds;radiotherapyXRCC4PGXsufentanilOPRM1PGX
atazanavirNR1I2PGXfluoxetineSLC6A4PGXsulfamethoxazoleGCLCPGX
atazanavirUGT1A1PGXfluoxetine;sertralineACEPGXsulfasalazineABCG2PGX
atazanavir;lopinavir;ritonavir;tenofovirABCC2PGXflurbiprofenCYP2C9FDAsulfinpyrazoneUGT1A9PGX
atazanavir;ritonavirUGT1A7PGXflurbiprofenCYP2C9PGXsulfonamides, urea derivativesTCF7L2PGX
atenololDPYSPGXfluticasone propionate;montelukastCA10PGXsulindacFMO3PGX
atenololGNB3PGXfluvastatinACEPGXsumatriptanGNB3PGX
atenolol;bisoprololPGXfluvastatinCETPPGXsunitinibABCB1PGX
atenolol;hydrochlorothiazideALDH1A2PGXfluvastatinSLCO1B1PGXsunitinibFLT3PGX
atenolol;hydrochlorothiazide;metoprololSLC25A31PGXfluvastatin;simvastatinLIPCPGXtacrolimusCYP3A5CPIC
atenolol;irbesartanEDN1PGXfluvoxamineCYP2B6CPICtacrolimusCYP3A5FDA
atenolol;metoprololADRB2PGXfluvoxamineCOMTPGXtacrolimusCYP3A4PGX
atenolol;verapamilCACNA1CPGXfluvoxamineFGF2PGXtalinololABCB1PGX
atomoxetineCYP2D6CPICfluvoxamineHTR2APGXtamoxifenCYP2D6CPIC
atomoxetineCYP2D6DPWGfluvoxamineCYP2D6FDAtamoxifenCYP2D6DPWG
atomoxetineCYP2D6FDAfluvoxamine;milnacipran;paroxetineHTR1APGXtamoxifenCYP2D6FDA
atomoxetineSLC6A2PGXfluvoxamine;paroxetineHTR2APGXtamoxifenCYP19A1PGX
atorvastatinAPOEPGXfolic acidMTHFRPGXtamoxifenUGT1A4PGX
atorvastatinSLCO1B1PGXfolic acid;methotrexateTLR4PGXtamsulosinCYP2D6FDA
atorvastatin;BisphosphonatesFDPSPGXfolic acid;vitamin b-complex, plainMTHFRPGXtaxanesPGX
atorvastatin;fluvastatin;hmg coa reductase inhibitors;lovastatin;pravastatin;simvastatinHMGCRPGXfolic acid;vitamin b-complex, plainMTRRPGXtegafurDPYDDPWG
atorvastatin;hmg coa reductase inhibitors;pravastatin;simvastatinHTR7PGXfollitropin beta;thyrotropin alfa;urofollitropinFSHRPGXtegafurDPYDPGX
atorvastatin;hmg coa reductase inhibitors;rosuvastatinCOQ2PGXforskolinABCB1PGXtelaprevirCYP24A1PGX
atorvastatin;lovastatin;simvastatinAPOA5PGXfurosemideABCC4PGXtelmisartanGNB3PGX
atorvastatin;pravastatin;simvastatinABCA1PGXfurosemide;spironolactoneADD1PGXtelmisartanSLCO1B3PGX
atorvastatin;quinaprilACEPGXgabapentinSLC7A5PGXtemozolomideABCB1PGX
atorvastatin;rifampinSLCO1B1PGXgalantamineCYP2D6FDAtenofovirABCC4PGX
atorvastatin;simvastatinPON1PGXgalantamineCHATPGXtenofovir disoproxil fumarateCYP27B1PGX
atorvastatin;simvastatinRYR2PGXgefitinibCYP2D6FDAtenoxicamCYP2C9CPIC
avatrombopagCYP2C9FDAgefitinibABCB1PGXterbutalineADRB2PGX
axitinib;sorafenibHIF1APGXgefitinibEGFRPGXtetrabenazineCYP2D6FDA
azathioprineNUDT15CPICgeldanamycinEGFRPGXthalidomideERCC1PGX
azathioprineNUDT15DPWGgemcitabineNT5C2PGXThiazides, plainGNB3PGX
azathioprineTPMTCPICgemcitabineRRM1PGXthiazolidinedionesAQP2PGX
azathioprineTPMTDPWGgemcitabine;paclitaxelCDAPGXthioguanineNUDT15CPIC
azathioprineTPMTFDAgemcitabine;paclitaxelSLC29A1PGXthioguanineTPMTCPIC
azathioprineFTOPGXgemcitabine;Platinum compoundsCASP7PGXthioguanineTPMTDPWG
azathioprineNUDT15PGXgemcitabine;Platinum compoundsRRM1PGXthioguanineTPMTFDA
azathioprine;mercaptopurinePGXgemtuzumab ozogamicinCD33PGXthioridazineCYP2D6FDA
azathioprine;mercaptopurine;thioguanineNUDT15PGXglatiramer acetatePGXthioridazineCYP2D6PGX
azathioprine;purine analoguesITPAPGXglibenclamideNOS1APPGXthiotepaGSTP1PGX
belinostatUGT1A1FDAgliclazideKCNJ11PGXtianeptineOPRM1PGX
benazeprilMTHFRPGXglimepirideNOS1APPGXticagrelorPEAR1PGX
benazepril;imidaprilAGTPGXglipizideNOS1APPGXtimololPGX
benazepril;perindoprilACEPGXglucocorticoidsHSD3B1PGXtiotropiumADRB2PGX
Beta Blocking AgentsADRB1PGXgranisetronABCB1PGXtipifarnibABCB1PGX
Beta Blocking AgentsGRK5PGXgranisetron;palonosetronERCC1PGXtipiracil hydrochloride;trifluridineSLC29A1PGX
Beta blocking agents, selectiveBST1PGXhaloperidolCYP2D6DPWGtocilizumabIL6RPGX
bevacizumabARMS2PGXhaloperidolMC4RPGXtolbutamideCYP2C9PGX
bevacizumabCFHPGXhaloperidolSLC6A5PGXtolterodineCYP2D6FDA
bevacizumabCXCR4PGXhalothaneCACNA1SPGXtopiramateGRIK1PGX
bevacizumabEDN1PGXhdl cholesterol;letrozole;triglyceridesCYP19A1PGXtopotecanABCG2PGX
bevacizumab;capecitabine;cetuximab;oxaliplatinMGAT4APGXHepatitis vaccinesIL4RPGXtramadolCYP2D6DPWG
bevacizumab;capecitabine;fluorouracil;irinotecan;leucovorin;oxaliplatinVEGFAPGXheroinOPRM1PGXtramadolCYP2D6FDA
bevacizumab;capecitabine;oxaliplatinMGAT4APGXheroinSOD2PGXtramadolOPRM1PGX
bevacizumab;carboplatin;cisplatin;cyanocobalamin;folic acid;pemetrexedMTHFRPGXheroin;methamphetamineBDNFPGXtrandolapril;verapamilPTPRDPGX
bevacizumab;fluorouracil;irinotecan;leucovorinSHMT1PGXheroin;opioidsOPRM1PGXtrastuzumabERBB2PGX
bevacizumab;pegaptanib;ranibizumabVEGFAPGXhighly active antiretroviral therapy (haart)OPRM1PGXtrastuzumabFCGR2APGX
bevacizumab;pemetrexedGGHPGXhmg coa reductase inhibitorsLPAPGXtriamcinoloneHCG22PGX
bevacizumab;ranibizumabVEGFAPGXhmg coa reductase inhibitorsSLCO1B1PGXtrimipramineCYP2C19CPIC
bilirubinUGT1APGXhmg coa reductase inhibitors;letrozoleCYP19A1PGXtrimipramineCYP2D6CPIC
bisantreneABCB1PGXhmg coa reductase inhibitors;simvastatinGATMPGXtrimipramineCYP2D6FDA
bisoprololACY3PGXhormonal contraceptives for systemic useF5PGXtroglitazonePGX
BisphosphonatesABCC4PGXHydralazine-isosorbide dinitrateGNB3PGXtropisetronCYP2D6CPIC
BisphosphonatesFDPSPGXhydrochlorothiazideADD1PGXTumor necrosis factor alpha (TNF-alpha) inhibitorsIL23RPGX
Bisphosphonates;clodronate;etidronic acid;risedronate;tiludronateIL1BPGXhydrochlorothiazideKCNJ1PGXTumor necrosis factor alpha (TNF-alpha) inhibitorsTNFPGX
Bisphosphonates;pamidronate;zoledronateCYP2C8PGXhydrocodoneOPRM1PGXTumor necrosis factor alpha (TNF-alpha) inhibitors;ustekinumabIL1BPGX
bleomycin;cisplatin;etoposideBLMHPGXhydroxyureaMAP3K5PGXustekinumabTIRAPPGX
bleomycin;cisplatin;etoposideGSTP1PGXibuprofenPTGS2PGXvalbenazineCYP2D6FDA
bleomycin;cyclophosphamide;doxorubicin;prednisone;rituximab;vincristine;vindesineABCB1PGXidarubicinNCF4PGXvalganciclovirABCB1PGX
boceprevir;peginterferon alfa-2a;peginterferon alfa-2b;ribavirinIFNL3;IFNL4PGXidarubicinRAC2PGXvalproic acidPOLGPGX
bortezomib;dexamethasone;melphalan;prednisoneCTLA4PGXiloperidoneCYP2D6FDAvalproic acidUGT1A6PGX
botulinum toxin type aTRPV1PGXiloperidoneCYP2D6PGXvancomycinPGX
brexpiprazoleCYP2D6DPWGimatinibCYP2B6PGXvardenafilCYP3A5PGX
brexpiprazoleCYP2D6FDAimatinibEGFRPGXvareniclineCHRNA4PGX
brivaracetamCYP2C19FDAimatinibSLC22A1PGXvenlafaxineCYP2D6DPWG
bucindololADRB1PGXimatinibSLC22A4PGXvenlafaxineCYP2D6FDA
budesonidePGXimipramineCYP2C19CPICvenlafaxineHTR2APGX
budesonide;flunisolide;fluticasone propionate;glucocorticoids;nedocromil;triamcinoloneGLCCI1PGXimipramineCYP2C19DPWGverapamilKCNIP1;KCNMB1PGX
bufuralol;dextromethorphanCYP2D6PGXimipramineCYP2D6CPICvincristineABCB1PGX
bumetanide;furosemide;torasemideSLC12A3PGXimipramineCYP2D6DPWGvincristineCEP72PGX
buprenorphineCOMTPGXimipramineCYP2D6FDAvitamin eCYP4F2PGX
buprenorphineOPRD1PGXimiquimodTLR7PGXVitamin KCYP4F2PGX
buprenorphine;fentanyl;meperidine;morphine;opioids;pentazocinePGXindinavirCYP3A4PGXvoriconazoleCYP2C19CPIC
buprenorphine;fentanyl;tramadolCOMTPGXindinavirUGT1A1PGXvoriconazoleCYP2C19DPWG
bupropionGALR1PGXinfliximabTNFPGXvoriconazoleCYP2C19FDA
bupropion;Drugs used in nicotine dependence;nicotine;vareniclineCHRNA5PGXinfliximab;Tumor necrosis factor alpha (TNF-alpha) inhibitorsTNFRSF1BPGXvoriconazoleCYP3A4PGX
bupropion;nicotineDRD1PGXinsulin recombinant;zinc acetateSLC30A8PGXvortioxetineCYP2D6FDA
bupropion;nicotine;vareniclineCHRNA5PGXinterferon alfa-2a, recombinant;interferon alfa-2b, recombinant;ribavirinFTOPGXwarfarinCYP2C9DPWG
busulfanCYP2C9PGXinterferon alfa-2a, recombinant;peginterferon alfa-2bIDO1PGXwarfarinCYP2C9FDA
busulfan;cyclophosphamideCTHPGXinterferon alfa-2b, recombinant;ribavirinITPAPGXwarfarinCYP4F2FDA
butorphanolCOMTPGXinterferon beta-1aRORAPGXwarfarinVKORC1FDA
caffeineADORA2APGXinterferon beta-1a;interferon beta-1bHLA-DQA1PGXwarfarinPGX
caffeineCYP1A2PGXinterferon beta-1a;interferon beta-1bIRF6PGXwarfarinCYP4F2PGX
calceinABCB1PGXinterferonsIFNL3;IFNL4PGXwarfarinVKORC1PGX
calcein;lopinavirABCC2PGXinterferonsSTAT3PGXXK469AOX1PGX
calciumVDRPGXinterferons;peginterferon alfa-2a;peginterferon alfa-2b;ribavirinIFNL3PGXzileutonPRORPPGX
calcium channel blockersCACNA1CPGXinterferons;ribavirinIL18PGXzoledronateFDPSPGX
calcium channel blockers;nitrendipineKCNH2PGXirbesartanCYP2C9PGXzuclopenthixolCYP2D6DPWG
candesartanAGTR1PGXirinotecanUGT1A1DPWG
cangrelorP2RY12PGXirinotecanUGT1A1FDA
cannabinoidsFAAHPGXirinotecanUGT1A1PGX
cannabinoids;cocaine;ethanol;nicotine;opioidsOPRM1PGXirinotecan;raltitrexedTYMSPGX
capecitabineDPYDCPICisofluraneCACNA1SPGX
capecitabineDPYDFDAisoniazidBACH1PGX
capecitabineDPYDPGXisoniazid;phenytoinNAT2PGX
capecitabineTYMSPGXisoniazid;pyrazinamide;rifampinNAT2PGX
capecitabine;docetaxelCYP1A1PGXisoniazid;rifampinGSTP1PGX
capecitabine;epirubicin;platinumGSTP1PGXisoproterenolADRB2PGX
capecitabine;fluorouracilHLA-GPGXivacaftorCFTRPGX
capecitabine;fluorouracil;leucovorin;oxaliplatinMTHFRPGXivacaftor-lumacaftorCFTRPGX
capecitabine;fluorouracil;tegafurTYMSPGXivacaftor-tezacaftorCFTRPGX
capecitabine;oxaliplatinPTGS2PGXketorolacPGX
capecitabine;radiotherapyAREGPGXl-methylfolate;Vitamin B-complex, Incl. CombinationsMTHFRPGX
captoprilACEPGXl-phenylalaninePAHPGX
carbamazepineHLA-ACPICl-tryptophanSLC22A2PGX
carbamazepineHLA-AFDAlamivudine;lopinavir;ritonavir;zidovudineABCB1PGX
carbamazepineHLA-BCPIClamotrigineUGT1A4PGX
carbamazepineHLA-BFDAlansoprazoleCYP2C19CPIC
carbamazepineCYP3A5PGXlansoprazoleCYP2C19DPWG
carbamazepineSCN1APGXlansoprazole;omeprazole;rabeprazoleIL1BPGX
carbamazepine;clobazam;ethosuximide;lamotrigine;levetiracetam;oxcarbazepine;valproic acidSCN1APGXlansoprazole;tacrolimusABCB1PGX
carbamazepine;oxcarbazepineSCN1APGXlapatinibHLA-DQA1FDA
carbamazepine;phenobarbital;phenytoin;valproic acidCYP1A1PGXlapatinibHLA-DRB1FDA
carbamazepine;phenytoin;valproic acidGABRA1PGXlatanoprostABCC4PGX
carbocisteinePAHPGXledipasvir;sofosbuvirIFNL3;IFNL4PGX
carboplatin;cisplatinEIF3APGXleflunomideESR1PGX
carboplatin;cisplatin;docetaxel;erlotinib;gefitinib;paclitaxelMAP3K1PGXlenalidomide;thalidomideCTNNB1PGX
carboplatin;cisplatin;docetaxel;gemcitabine;paclitaxelRAF1PGXletermovirSLCO1B1PGX
carboplatin;cisplatin;docetaxel;paclitaxelPGXletrozoleESR1PGX
carboplatin;cisplatin;fluorouracilSLC19A1PGXlevodopaHOMER1PGX
carboplatin;cisplatin;gemcitabineGPX5PGXlevodopaSLC6A3PGX
carboplatin;cisplatin;oxaliplatin;platinum;Platinum compoundsERCC1PGXliraglutideGLP1RPGX
carboplatin;cyclophosphamide;thiotepaALDH1A1PGXlisinoprilACEPGX
carboplatin;docetaxel;paclitaxelBCL2PGXlithiumASIC2PGX
carboplatin;docetaxel;trastuzumabERBB3PGXlithium;valproic acidPGX
carboplatin;gemcitabineCYP2C8PGXlofexidineCYP2D6FDA
carboplatin;lonafarnib;paclitaxelFNTBPGXlopinavirSLCO1B1PGX
carboplatin;paclitaxelMAD1L1PGXlorazepamUGT2B15PGX
carboplatin;paclitaxelSLCO1B3PGXlosartanSTK39PGX
carboplatin;taxanesGSRPGXlovastatinLDLRPGX
carisoprodolCYP2C19FDAlovastatin acidSLCO1B1PGX
carvedilolCYP2D6FDAlumacaftorCFTRPGX
carvedilolADRB2PGXlumefantrineCYP3A4PGX
catecholaminesADRB1PGXlurasidoneHTR1APGX
catecholamines;metforminSLC22A3PGXMeasles vaccinesTLR3PGX
cavosonstatCFTRPGXmeclizineCYP2D6FDA
cefotaximeSLC22A8PGXmeloxicamCYP2C9CPIC
ceftriaxoneABCG2PGXmelphalanSLC7A5PGX
celecoxibCYP2C9FDAmemantineNR1I2PGX
celecoxibALOX12PGXmephenytoinCYP2C19PGX
cerivastatinSLCO1B1PGXmercaptopurineNUDT15CPIC
cetuximabEGFPGXmercaptopurineTPMTCPIC
cetuximab;irinotecan;leucovorin;tegafurEGFRPGXmercaptopurineTPMTFDA
cetuximab;irinotecan;panitumumabAREGPGXmercaptopurineFTOPGX
cetuximab;panitumumabKRASPGXmercaptopurineNUDT15PGX
cevimelineCYP2D6FDAmercaptopurine;methotrexateITPAPGX
chlorothiazide;hydrochlorothiazidePGXmetforminSLC22A1PGX
chlorpromazine;clozapine;haloperidol;olanzapine;quetiapine;risperidone;trifluoperazineEPM2APGXmetforminSLC47A1PGX
chlorthalidone;lisinoprilMMP3PGXmetformin;sulfonamides, urea derivativesKCNJ11PGX
cisplatinACYP2PGXmethacholineADRB2PGX
cisplatinERCC1PGXmethadoneABCB1PGX
cisplatin;cyclophosphamideCYP2E1PGXmethadoneCYP3A4PGX
cisplatin;cyclophosphamideGSTM3PGXmethamphetamineFAAHPGX
cisplatin;cyclophosphamide;doxorubicin;methotrexate;vincristineABCC3PGXmethotrexateATICPGX
cisplatin;fluorouracilGALNT14PGXmethotrexateMTHFRPGX
cisplatin;fluorouracil;mitoxantroneGALNT14PGXmethotrexateSLC19A1PGX
cisplatin;fluorouracil;oxaliplatinVEGFAPGXmethoxyfluraneCACNA1SPGX
cisplatin;fluorouracil;radiotherapyMUTYHPGXmethylphenidateCES1PGX
cisplatin;gemcitabineRRM1PGXmethylphenidateDRD2PGX
cisplatin;irinotecanUBE2IPGXmethylphenidateSLC6A2PGX
cisplatin;oxaliplatin;Platinum compoundsGSTP1PGXmethylprednisolone;prednisoloneABCB1PGX
cisplatin;oxaliplatin;platinum;Platinum compoundsERCC2;KLC3PGXmetoclopramideCYP2D6FDA
cisplatin;pemetrexedABCC2PGXmetoprololCYP2D6DPWG
citalopramCYP2C19CPICmetoprololCYP2D6FDA
citalopramCYP2C19DPWGmetoprololADRB1PGX
citalopramCYP2C19FDAmidazolamPORPGX
citalopramHTR2APGXmigalastatGLAPGX
citalopram;escitalopramPGXmilnacipranHTR1APGX
citalopram;fluoxetineGSK3BPGXmirabegronCYP2D6FDA
citalopram;fluoxetine;paroxetine;sertralineREEP5PGXmirtazapineFKBP5PGX
cladribine;cytarabineRRM1PGXmirtazapine;venlafaxineTPH2PGX
cladribine;fluorouracil;gemcitabineNT5C1APGXmitotaneCYP2B6PGX
clobazamCYP2C19FDAmivacuriumBCHEFDA
clodronateVDRPGXmodafinilABCB1PGX
clomipramineCYP2C19CPICmontelukastLTA4HPGX
clomipramineCYP2C19DPWGmorphineKCNJ6PGX
clomipramineCYP2D6CPICmorphineOPRM1PGX
clomipramineCYP2D6DPWGmorphine;nortriptylineABCB1PGX
clomipramineCYP2D6FDAmuraglitazarEDN1PGX
clomipramine;liothyronine;lithium;nefazodone;venlafaxineHTR1BPGXmycophenolate mofetilSLCO1B3PGX
clomipramine;lithium;nefazodone;paroxetine;venlafaxineABCB1PGXmycophenolic acidSLCO1B3PGX
clomipramine;nefazodone;paroxetine;venlafaxineFKBP5PGXnaloxoneOPRM1PGX
clonidineGNB3PGXnaltrexoneDBHPGX
clopidogrelCYP2C19CPICnaproxenCYP2C9PGX
clopidogrelCYP2C19DPWGnateglinideSLCO1B1PGX
clopidogrelCYP2C19FDAnebivololCYP2D6FDA
clopidogrelCES1PGXnelfinavirCYP2C19PGX
clozapineCYP2D6FDAnemonaprideANKK1PGX
clozapineABCB1PGXnevirapineCYP2B6PGX
clozapineHTR2CPGXnicotineCHRNA3PGX
clozapineNTRK2PGXnicotineCHRNA5PGX
clozapine;olanzapineMC4RPGXnicotine;Opium alkaloids and derivativesCHRNA5PGX
clozapine;olanzapine;risperidoneDRD2PGXnifedipineSLC14A2PGX
cocaineDRD2PGXnilotinibUGT1A1FDA
cocaineOPRM1PGXnimodipineCACNA1CPGX
cocaine;ethanol;nicotineOPRM1PGXnitrendipineAGTR1PGX
cocaine;heroinOPRM1PGXnitroprussideACEPGX
codeineCYP2D6CPICnitrous oxideMTHFRPGX
codeineCYP2D6DPWGnortriptylineCYP2D6CPIC
codeineCYP2D6FDAnortriptylineCYP2D6DPWG
codeineOPRM1PGXnortriptylineCYP2D6FDA
conjugated estrogensSULT1A1PGXnortriptylineABCB1PGX
conjugated estrogens;medroxyprogesteroneVDRPGXnortriptylineGNB3PGX
corticosteroidsBCL2L11PGX
corticosteroidsCRHR1PGX
corticosteroids;selective beta-2-adrenoreceptor agonistsADRB2PGX
cotinineCHRNA5PGX
cotinine glucuronideUGT1A9PGX
cotinine;nicotineOPRM1PGX
coumarinCYP2A6PGX
creatineMOBPPGX
curcumin;ivacaftorCFTRPGX
cyclophosphamideABCC4PGX
cyclophosphamideCYP2C19PGX
cyclophosphamideSOD2PGX
cyclophosphamide;cytarabine;daunorubicin;mercaptopurine;methotrexate;prednisone;vincristineDROSHAPGX
cyclophosphamide;dexamethasone;lenalidomide;thalidomideCTNNB1PGX
cyclophosphamide;docetaxelVEGFAPGX
cyclophosphamide;docetaxel;doxorubicin;epirubicin;fluorouracilSLCO1B1PGX
cyclophosphamide;doxorubicinCYP2C19PGX
cyclophosphamide;doxorubicin;fluorouracilATMPGX
cyclophosphamide;doxorubicin;fluorouracilSLC22A16PGX
cyclophosphamide;doxorubicin;fluorouracil;methotrexateNOS3PGX
cyclophosphamide;doxorubicin;prednisone;rituximab;vincristineGSTA1PGX
cyclophosphamide;epirubicinGSTP1PGX
cyclophosphamide;epirubicin;fluorouracilNQO1PGX
cyclophosphamide;epirubicin;fluorouracilPIGBPGX
cyclophosphamide;epirubicin;paclitaxelCYP1B1PGX
cyclophosphamide;fluorouracil;methotrexateFGFR4PGX
cyclosporineCYP3A4PGX
cyclosporineCYP3A5PGX
cyclosporine;dicloxacillinABCB1PGX
cyclosporine;mycophenolate mofetilIL10PGX
cyclosporine;mycophenolate mofetil;sirolimus;tacrolimusUGT1A8PGX
cyclosporine;mycophenolic acidABCC2PGX
cyclosporine;sirolimus;tacrolimusTCF7L2PGX
cyclosporine;tacrolimusCRTC2PGX
cysteamineCFTRPGX
cytarabineCDAPGX
cytarabine;daunorubicin;dexrazoxane;idarubicinABCB1PGX
cytarabine;daunorubicin;etoposide;mitoxantroneSLCO1B1PGX
cytarabine;fludarabine;gemtuzumab ozogamicin;idarubicinCYP2E1PGX
cytarabine;idarubicinNT5C3APGX

Summary

There you have it! With information, free is not always good and useful. A lot of users come to Xcode after having tried Promethease for $5. If you just want to satisfy your curiosity and not really looking for anything specific, then Promethease may be the way to go. But, if you want specific, organized, and actionable insights from your genetic data about your health and wellbeing, then you certainly must try the Xcode Health reports!

About Xcode Life

Updated on January 15th, 2022

1. How to read your Promethease report?

To read your Promethease review report you will need to ensure that you are accustomed to some of the terms that are found in their report like magnitude and repute. It is difficult to sift through thousands of pages in your report. Once you organize the pages as per your unique needs it becomes a relatively easy task to. 

2. What is Promethease?

Promethease is a do-it-yourself (DIY) tool for health genetic information from 23andMe raw data. It is a third party online tool that provides consumers information about their genetic variants and how they affect your health. After 23andme FDA ban on providing health reports, people started using tools like Promethease to get more information from their DNA raw data, other than just locating distant cousins. Though Promethease is a good tool built on a repository like SNPedia there are a number of factors to consider before you decide to upload your raw data to Promethease. Promethease is popular as a low-cost offering, but it’s also very technical and disease-centric. There are many alternatives to Promethease to analyze your 23andme raw data, that are easy to follow and understand. Below we present a feature by feature comparison between Promethease and Xcode Life Sciences.

3. How did Promethease gain popularity?

Promethease was one of the early companies to offer health reports based on 23andme data. When the FDA (briefly) banned 23andme from providing health reports, Promethease was the only alternative and gained popularity because of its (almost) free service.

4. How long does it take to get my Promethease reports?

Promethease takes approximately 20 minutes to generate health report from your raw data.

5. What does Promethease provide?

Promethease provides health report for $5 based on 23andme, Ancestry DNA, Family Tree DNA. Promethease provides the genetic risk for a number of diseases. Many users try the Promethease reports due to the cost aspect. However, there are several reports of panicked and confused Promethease users online.

6. What exactly do you get to know from a Promethease report?

Promethease is a wiki-style collection of peer curated (not expert-curated) genetic information. You can search `genes/variants/diseases’ as you would in Wikipedia. A Promethease report is essentially a data dump, leaving the user to wade through a whole lot of science, statistics, charts, and graphs. This is great for people who want to geek out and want to learn about all sorts of diseases they can get!!

However, if you want organized information that you can use in specific aspects of daily life such as Nutrition, Fitness, Personalized medicine, etc., to enhance your health and wellbeing, then you may not find the Promethease reports all that helpful. Promethease’ emphasis largely seems to be the variety of different diseases that one can get.

7. How do I understand my Promethease report?

Please be aware that your report may cause you anxiety. Many individuals carry risk variants that will not manifest in the form of a disease. Promethease report will indicate that your risk for several diseases is several times higher than the normal population- be prepared!  You will find many forums on the internet where users have shared their experience of being alarmed by their Promethease report and did further testing for that condition.

8. Will getting the health test from 23andme give me better results?

A lot of people think that getting the additional health report from 23andme will help them get better results. That is not true! Whether you order the Health report or the Ancestry report from 23andme, the raw data you receive is the same!

9. How does Promethease work?

This third party DNA raw data analysis tool, is a literature retrieval system from SNPedia which is a Wikipedia style repository where people can add information. It is not a systematic risk assessment tool. For example, for Alzheimer’s disease (AD), you will not get a summary of your risk for developing AD. Instead, you will get a list of scientific literature that is available that indicates or does not indicate your risk for AD for a specific variant. For a particular disease or trait, if there are 15 articles that report on that particular DNA location, based on your SNPs 2 information sources might indicate an increased risk, 5 might be neutral, and 3 towards the lower side. Promethease does not summarise these for you. Rather it returns all these 10 articles and makes you do the interpreting yourself. This is the major reason why many individuals are alarmed and confused by their Promethease report.

10. How accurate is Promethease?

The vast majority of human traits are polygenic, meaning, several genes contribute towards that trait. Even if one carries a disease variant, they may also be carrying variants that reduce the risk of disease. Even in the case of Monogenic conditions- where one single gene leads to disease, scientist have found individuals carrying these deadly mutations but apparently healthy with no sign of disease. In a majority of the cases, the genetic risk is a small contributor towards the overall risk of that disease/condition. So, one must consider all of these things in interpreting their report. 

11. Where does Promethease get all its information?

Promethease only relies on SNPedia. Several other notable and high scientific authority tools are left out from the Promethease reports.

12. How do I filter through the Promethease report?

It is impractical to sift through the dump of information that you get (anticipate about 48,000 rows of data). The tool is equipped with different kinds of filters aimed at assisting you. Some of them are gene names, haplogroup names, diseases, drug names (referred to as “medicines”), medical conditions, names of genes and race.

13. What is magnitude in Promethease?

Magnitude is a subjective parameter that measures the interest level of the information. Here is the table partially resourced from the SNPedia website that describes what each numerical value indicates.

A-CD-FG-HI-NO-Z
3 beta-Hydroxysteroid dehydrogenase deficiencyDeafness, autosomal recessive 77Glucose-6-phosphate dehydrogenase (G6PD) deficiencyInclusion Body Myopathy 2Ornithine aminotransferase deficiency
3-Phosphoglycerate Dehydrogenase DeficiencyDeficiency of acetyl-CoA acetyltransferaseGalactosylceramide beta-galactosidase deficiencyInfantile Sialic acid storage disease; Salla diseaseOrnithine carbamoyltransferase deficiency
AbetalipoproteinaemiaDeficiency of alpha-mannosidaseGaucher diseaseIsovaleryl-CoA dehydrogenase deficiencyPartial adenosine deaminase deficiency
Achondrogenesis, type IB; Multiple epiphyseal dysplasia type 4; Atelosteogenesis type II; Diastrophic dysplasiaDeficiency of galactokinaseGitelman SyndromeJoubert Syndrome 2 / Meckel Syndrome 2Pendred syndrome
AchromatopsiaDeficiency of guanidinoacetate methyltransferaseGlutaric acidemia type 1Joubert syndrome 28Peroxisomal acyl-CoA oxidase deficiency
Acute infantile liver failure due to synthesis defect of mtDNA-encoded proteinsDeficiency of hydroxymethylglutaryl-CoA lyaseGlutaric acidemia type 2AJoubert syndrome 5Phenylketonuria
Acyl-CoA dehydrogenase family, member 9 deficiencyDeficiency of steroid 11-beta-monooxygenaseGlutaric acidemia type 2CJoubert syndrome 7Phosphoribosylpyrophosphate synthetase superactivity
AdrenoleukodystrophyDeficiency of UDPglucose-hexose-1-phosphate uridylyltransferaseGlycine encephalopathy (AMT-related)Junctional epidermolysis bullosa (LAMA3 related)Polyglandular autoimmune syndrome, type 1
Adult polyglucosan body neuropathyDihydrolipoamide dehydrogenase deficiencyGlycine encephalopathy (GLDC-related)Junctional epidermolysis bullosa (LAMB3 related)Polymicrogyria
Aicardi Goutieres syndrome 5Duchenne muscular dystrophyGlycogen storage disease due to glucose-6-phosphatase deficiency type IAJunctional epidermolysis bullosa (LAMC2 related)Pontocerebellar hypoplasia type 1A
Alpha thalassemia-X-linked intellectual disability syndromeDyskeratosis congenita, autosomal recessive, 5Glycogen storage disease type 1BJuvenile retinoschisisPontocerebellar hypoplasia type 2D
Alport Syndrome (COL4A3-related)Dystrophic epidermolysis bullosaGlycogen storage disease type 2Lamellar Ichthyosis, Type 1Pontocerebellar hypoplasia type 6
Alport Syndrome (COL4A4-related)Ehlers-Danlos syndrome dermatosparaxis typeGlycogen storage disease type 3Laminin alpha 2-related dystrophyPrimary carnitine deficiency
Alport Syndrome, X-linked (COL4A5-related)Ellis-van Creveld syndrome (EVC-related)Glycogen storage disease type 4Laryngo-onycho-cutaneous syndromePrimary Ciliary Dyskinesia (DNAH11-related)
Alstrom syndromeEllis-van Creveld syndrome (EVC2-related)Glycogen storage disease type 5Leber congenital amaurosis 10Primary Ciliary Dyskinesia (DNAH5-related)
Anauxetic dysplasia; Cartilage-hair hypoplasia; Metaphyseal dysplasia without hypotrichosisEmery-Dreifuss muscular dystrophy, X-linkedGlycogen storage disease type 7Leber congenital amaurosis 13Primary Ciliary Dyskinesia (DNAI1-related)
Andermann SyndromeEnhanced s-cone syndromeGRACILE syndrome/ BCS1L-related disordersLeber congenital amaurosis 2Primary Ciliary Dyskinesia (DNAI2-related)
Arginase deficiencyEthylmalonic encephalopathyHemochromatosis type 2ALeber congenital amaurosis 5Primary hyperoxaluria type I
Argininosuccinate lyase deficiencyFabry diseaseHemochromatosis type 3Leber congenital amaurosis 8Primary hyperoxaluria type II
Aromatase deficiencyFamilial dysautonomiaHereditary acrodermatitis enteropathicaLeigh syndrome, French Canadian typePrimary hyperoxaluria type III
Arthrogryposis, mental retardation, and seizuresFamilial hypercholesterolemia (LDLR related)Hereditary factor IX deficiency diseaseLethal congenital contracture syndromeProgressive familial intrahepatic cholestasis 2
Arts syndromeFamilial hypercholesterolemia (LDLRAP1 related)Hereditary fructosuriaLeukoencephalopathy with vanishing white matterPropionic acidemia (PCCA related)
Asparagine synthetase deficiencyFamilial Hyperinsulinism, ABCC8-RelatedHereditary insensitivity to pain with anhidrosisLimb-girdle muscular dystrophy type 2APropionic acidemia (PCCB related)
AspartylglucosaminuriaFamilial isolated deficiency of vitamin EHereditary spastic paraplegia 15Limb-girdle muscular dystrophy type 2BPyknodysostosis
Ataxia-telangiectasia syndromeFanconi anemia type AHermansky-Pudlak syndrome type 1Limb-girdle muscular dystrophy type 2CPyruvate carboxylase deficiency
Autosomal recessive osteopetrosis 1Fanconi anemia type CHermansky-Pudlak syndrome type 3Limb-girdle muscular dystrophy type 2DPyruvate dehydrogenase E1-alpha deficiency
Autosomal recessive polycystic kidney diseaseFanconi anemia type GHolocarboxylase synthetase deficiencyLimb-girdle muscular dystrophy type 2EPyruvate dehydrogenase E1-beta deficiency
Bardet-Biedl syndrome 1Fetal akinesia deformation sequenceHomocystinuria (CBS related)Limb-girdle muscular dystrophy type 2FRenal tubular acidosis with progressive nerve deafness
Bardet-Biedl syndrome 10Finnish congenital nephrotic syndromeHomocystinuria due to MTHFR deficiencyLong-chain 3-hydroxyacyl-CoA dehydrogenase deficiencyRetinitis pigmentosa 20
Bardet-Biedl syndrome 12Fragile X syndromeHomocystinuria, cobalamin E typeLysinuric protein intoleranceRetinitis pigmentosa 25
Bardet-Biedl syndrome 13Fukuyama congenital muscular dystrophyHydrolethalus syndromeLysosomal acid lipase deficiencyRetinitis pigmentosa 26
Bardet-Biedl syndrome 14Fumarase deficiencyHyperlipoproteinemia, type IMaple syrup urine disease type 1ARetinitis pigmentosa 28
Bardet-Biedl syndrome 2Hyperornithinemia-hyperammonemia-homocitrullinuria syndromeMaple syrup urine disease type 1BRetinitis pigmentosa 59
Bare lymphocyte syndrome 2Hypohidrotic X-linked ectodermal dysplasiaMaple syrup urine disease type 2Retinitis pigmentosa 73
Bartter disease type 4aHypophosphatasiaMeckel-Gruber syndromeRetinitis pigmentosa 76
BH4-deficient hyperphenylalaninemia AMeckel syndrome type 1Rhizomelic chondrodysplasia punctata type 1/ Refsum disease (PEX7-related)
Bifunctional peroxisomal enzyme deficiencyMeckel syndrome type 4Rhizomelic chondrodysplasia punctata type 3
Bloom syndromeMeckel syndrome, type 5Roberts-SC phocomelia syndrome
Canavan DiseaseMedium-chain acyl-coenzyme A dehydrogenase deficiencySandhoff disease
Carnitine palmitoyltransferase I deficiencyMegalencephalic leukoencephalopathy with subcortical cysts 1Schimke immuno-osseous dysplasia
Carnitine palmitoyltransferase II deficiencyMenkes kinky-hair syndromeSegawa syndrome
Carpenter syndrome 1Metachromatic leukodystrophy (ARSA related)Senior-Loken syndrome 6
Cerebrotendinous xanthomatosisMetachromatic leukodystrophy due toSevere combined immunodeficiency (RAG2-related)
Charcot-Marie-Tooth disease type 4Dsaposin-b deficiencySevere combined immunodeficiency due to ADA deficiency
Charcot-Marie-Tooth disease, X-linkedMethylmalonic acidemia (MMAA related)Severe combined immunodeficiency due to DCLRE1C deficiency
Charcot-Marie-Tooth Neuropathy XMethylmalonic acidemia (MMAB related)Severe combined immunodeficiency, X-linked
Charlevoix-Saguenay spastic ataxiaMethylmalonic Aciduria and Homocystinuria, Type cblCSevere congenital neutropenia 3
ChoreoacanthocytosisMethylmalonic Aciduria and Homocystinuria, Type cblDSevere congenital neutropenia 5, autosomal recessive
ChoroideremiaMicrocephaly, postnatal progressive, with seizures and brain atrophySevere X-linked myotubular myopathy
Chronic granulomatous disease (CYBA related)Microphthalmia /clinical anophthalmia (VSX2-related)Sjögren-Larsson syndrome
Chronic granulomatous disease, X-linkedMitochondrial complex I deficiency/ Leigh syndrome (NDUFAF5-related)Smith-Lemli-Opitz syndrome
Citrin deficiencyMitochondrial complex I deficiency/ Leigh syndrome (NDUFAF6-related)Spastic paraplegia 49, autosomal recessive
Citrullinemia type IMitochondrial DNA depletion syndrome 1 (MNGIE type)Spinal muscular atrophy
Cockayne syndrome type AMPV17-related mitochondrial DNA maintenance defectSpondylocostal dysostosis
Cockayne syndrome type BMucolipidosis type IISteel syndrome
Cohen syndromeMucolipidosis type III gammaStuve-Wiedemann Syndrome
Combined malonic and methylmalonic aciduriaMucolipidosis type IVTay-Sachs disease
Combined oxidative phosphorylation deficiency 1Mucopolysaccharidosis type I (Hurler syndrome)Tooth agenesis, selective, 4; Odonto-onycho-dermal dysplasia; Schopf-Schulz-Passarge syndrome
Combined oxidative phosphorylation deficiency 3Mucopolysaccharidosis type II (Hurler syndrome)Tyrosinemia type I
Combined Pituitary Hormone Deficiency-2Mucopolysaccharidosis type IIIATyrosinemia type II
Combined Pituitary Hormone Deficiency-3Mucopolysaccharidosis type IIIB (Sanfilippo B)Usher syndrome type 1B
Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiencyMucopolysaccharidosis type IIICUsher syndrome type 1C
Congenital adrenal hyperplasia due to 21-hydroxylase deficiencyMucopolysaccharidosis type IIIDUsher syndrome type 1D
Congenital Adrenal HyperplasiaMucopolysaccharidosis type IVB (Morquio B syndrome)/ GM1 gangliosidosisUsher syndrome type 1F
Congenital amegakaryocytic thrombocytopeniaMucopolysaccharidosis type IXUsher syndrome type 2A
Congenital bilateral aplasia of vas deferens from CFTR mutationMucopolysaccharidosis type VIUsher syndrome type 3A
Congenital disorder of glycosylation type 1AMultiple sulfatase deficiencyVery long-chain acyl-CoA dehydrogenase deficiency
Congenital disorder of glycosylation type 1BMuscular dystrophy-dystroglycanopathy, FKTN-relatedWalker-Warburg congenital muscular dystrophy
Congenital disorder of glycosylation type 1CMyopathy, lactic acidosis, and sideroblastic anemia 1Werdnig-Hoffmann disease
Congenital hyperammonemia, type IN-acetylglutamate Synthase DeficiencyWilson disease
Congenital HyperinsulinismNemaline myopathy 2Xeroderma pigmentosum group A
Congenital muscular dystrophy-dystroglycanopathyNephrogenic diabetes insipidusXeroderma pigmentosum, group C
Congenital myasthenic syndromeNephrotic syndrome, idiopathic, steroid-resistantZellweger spectrum disorder (PEX1-related)
Congenital myasthenic syndrome (CHRNE)Neuronal ceroid lipofuscinosis 1Zellweger spectrum disorder (PEX10-related)
Corneal dystrophy-perceptive deafness syndromeNeuronal ceroid lipofuscinosis 2Zellweger spectrum disorder (PEX12-related)
Corneal endothelial dystrophyNeuronal ceroid lipofuscinosis 3Zellweger spectrum disorder (PEX2-related)
Corticosterone Methyloxidase DeficiencyNeuronal ceroid lipofuscinosis 5Zellweger spectrum disorder (PEX6-related)
Costeff Syndrome (3-Methylglutaconic Aciduria, Type 3)Neuronal ceroid lipofuscinosis 6
Creatine transporter deficiencyNeuronal ceroid lipofuscinosis 7
Cystic fibrosisNeuronal ceroid lipofuscinosis 8
CystinosisNiemann-Pick disease type C1
Niemann-Pick disease type C2
Niemann-Pick Disease, Types A/B
Nijmegen breakage syndrome
Nonsyndromic hearing loss and deafness

14. What is Promethease repute?

Good repute: The variation has a positive influence on you.

Not set: There is no verified information on the nature of the variation.

Bad repute: The variation has a negative influence on you.

According to the SNPedia website, it is better to leave the repute as “Not Set” as all genotypes have a little of both the “good” and “bad” repute.

15. What are ClinVar diseases?

This option allows you to see only the SNPs present in ClinVar. ClinVar is a freely accessible public archive of information on genetic variations specifically with clinical implications. It is maintained by the National Institute of Health (NIH). When you filter using this option you will find all the medical conditions that have been formally labeled by ClinVar.

16. How is Xcode Life different from Promethease?

Xcode Life, on the other hand, includes expert-curated references not just from SNPedia but also from several large and high scientific authority databases, including UK biobank, Clinvar, OMIM, and leading scientific journals to name a few,  to curate the variant annotations. Disease risk is indicated as an average of all variants the individual carries and not a single variant. In this methodology, unless the individual truly carries a combination of several high-risk variants, their result will not be indicated as high risk.

The information is then organized systematically into topical reports such as Nutrition, Health, Precision Medicine, Fertility, Fitness, Skin, Allergy, etc. Each report is further organized into traits, which provide actionable insights into your genetic type along with specific recommendations for you. Xcode reports are easily readable, understandable and implementable. The core philosophy of Xcode reports is to empower the user with actionable genetic information that they can use to enhance health and wellbeing.

As an alternative to this third party tool, many people use 23andme raw data analysis and interpretation third-party tools and services.  One such provider is Xcode Life which is a global genetics and bioinformatics company which specializes in 23andme raw data analysis and interpretation using genetic raw data from all major international data providers such as 23andme, Family Tree DNA (FTDNA), AncestryDNA.com, Helix.com, Living DNA, National Geographic and others . Xcode Life provides all the information and much more, but there are key differences for you to note. These reports come with DNA raw data analysis and interpretation and specific recommendations for people with your genetic type. Counseling is also available, upon request. Xcode provides reports to individuals and professional practitioners such as physicians, surgeons, nutritionists, sports trainers, chiropractic and other professionals. These reports are focused and consumer-friendly and are designed specifically for practical use. 

Drug (A-C)GeneGuidelinesDrug (D-N)GeneGuidelinesDrug (O-Z)GeneGuidelines
(R)-methadone;(S)-EDDP;methadoneUGT2B7PGXDabigatranCES1PGXo-desmethyltramadol;tramadolRFPL4BPGX
3,4-methylenedioxymethamphetamineSLC6A2PGXdaclatasvir;peginterferon alfa-2a;peginterferon alfa-2b;ribavirinIFNL3;IFNL4PGXolanzapineABCB1PGX
abacavirHLA-BCPICdalcetrapibADCY9PGXolanzapineBDNFPGX
abacavirHLA-BDPWGdapsoneHLA-DRB1PGXolanzapineGIPRPGX
abacavirHLA-BFDAdaptomycinABCB1PGXolanzapine;perphenazineRGS4PGX
abacavirLST1;LTA;LTBPGXdarifenacinCYP2D6FDAolanzapine;risperidoneDRD2PGX
abiraterone;prednisoloneDSE;TSPYL1PGXdasatinib;imatinibABCG2PGXolanzapine;risperidoneHTR2APGX
ABT-751UGT1A4PGXdasatinib;imatinib;nilotinibABCG2PGXomeprazoleCYP2C19CPIC
acamprosateGRIN2BPGXdaunorubicinNOS3PGXomeprazoleCYP2C19DPWG
Ace Inhibitors;PlainXPNPEP2PGXdebrisoquineCYP2D6PGXomeprazoleCYP2C19FDA
Ace Inhibitors;Plain;Angiotensin II Antagonists;Beta Blocking Agents;digoxin;diuretics;spironolactoneADRB2PGXdeferasiroxABCG2PGXomeprazoleABCB1PGX
Ace Inhibitors;Plain;Angiotensin II Antagonists;Beta Blocking Agents;digoxin;diuretics;spironolactoneNOS3PGXdeferasiroxUGT1A3PGXondansetronCYP2D6CPIC
acenocoumarolCYP4F2PGXdeferiproneUGT1A6PGXondansetronABCB1PGX
acenocoumarolVKORC1PGXdeleobuvir;faldaprevirIFNL3;IFNL4PGXOpioid anesthetics;Other general anesthetics;volatile anestheticsOPRM1PGX
acenocoumarol;phenprocoumonVKORC1PGXdesfluraneCACNA1SPGXopioidsOPRM1PGX
acenocoumarol;warfarinAPOEPGXdesflurane;enflurane;halothane;isoflurane;methoxyflurane;sevoflurane;succinylcholineRYR1PGXOpium alkaloids and derivativesCHRNA3PGX
acetaldehydeALDH2PGXdesipramineCYP2D6CPICOpium alkaloids and derivativesCHRNA5PGX
acetaldehydePGM1PGXdesipramineCYP2D6FDAoseltamivirABCB1PGX
acetaminophenTRPV1PGXdesipramineMC1RPGXoxaliplatinABCB1PGX
acetaminophenUGT1APGXdesloratadineHRH1PGXoxazepamUGT2B15PGX
acetaminophen;aspirin;diclofenac;propionic acid derivatives;PyrazolonesPLA2G4APGXdesloratadine;mizolastineFCER1APGXoxcarbazepineHLA-BCPIC
acetaminophen;ibuprofen;loxoprofen;salicylamidePGXdeutetrabenazineCYP2D6FDAoxcarbazepineHLA-BFDA
acetaminophen;tramadolOPRM1PGXdexamethasoneSERPINE1PGXoxcarbazepineABCB1PGX
acetylcholineACEPGXdexamethasone;doxorubicin;vincristineABCB1PGXoxycodoneCOMTPGX
acetylcysteineTOLLIPPGXdexamethasone;lenalidomideABCB1PGXpaclitaxelABCB1PGX
adalimumabATG16L1PGXdexlansoprazoleCYP2C19CPICpaclitaxel;Platinum compoundsCASP7PGX
adalimumabHFEPGXdexlansoprazoleCYP2C19FDApaliperidoneMC4RPGX
adalimumab;certolizumab pegol;etanercept;glucocorticoids;infliximab;methotrexateKLRD1PGXdexmedetomidineADRA2APGXpantoprazoleCYP2C19CPIC
adalimumab;etanercept;infliximabFCGR3APGXdextroamphetamine;methylphenidateDRD1PGXpantoprazoleCYP2C19DPWG
adalimumab;etanercept;infliximab;Tumor necrosis factor alpha (TNF-alpha) inhibitorsTRAF1PGXdiazepamCYP2C19FDApantoprazoleCYP2C19FDA
adalimumab;infliximabFCGR2APGXdicloxacillinABCB1PGXpantoprazoleABCB1PGX
adefovir dipivoxilSLC22A6PGXdidanosineNT5C2PGXparoxetineCYP2D6CPIC
adefovir dipivoxil;cidofovir;tenofovirSLC22A6PGXdifluorodeoxyuridineCDAPGXparoxetineCYP2D6DPWG
adrenergics, inhalantsPGXdigoxinABCB1PGXparoxetineCYP2D6FDA
agomelatineABCB1PGXDihydropyridine derivativesNOS1APPGXparoxetineCYP1A2PGX
alemtuzumab;chlorambucil;cyclophosphamide;fludarabine;prednisone;rituximab;vincristineCXCL12PGXdiltiazemPLCD3PGXparoxetineHTR1APGX
alendronateVDRPGXdimethyl fumarateGSTP1PGXpazopanibHLA-BFDA
alfentanilOPRM1PGXDipeptidyl peptidase 4 (DPP-4) inhibitorsCDKAL1PGXpazopanibUGT1A1FDA
Alkylating AgentsEGFRPGXdirect acting antiviralsIFNL4PGXpeginterferon alfa-2aIFNL3;IFNL4PGX
Alkylating Agents;cisplatinESR1PGXdisopyramideKCNH2PGXpeginterferon alfa-2a;peginterferon alfa-2bIFNL3;IFNL4PGX
allopurinolHLA-BCPICdisulfiramSLC6A3PGXpeginterferon alfa-2a;peginterferon alfa-2b;ribavirinIFNL3PGX
allopurinolHLA-BFDAdiureticsPDE4DPGXpeginterferon alfa-2a;peginterferon alfa-2b;ribavirinIFNL3;IFNL4PGX
allopurinolABCG2PGXdiuretics;hydrochlorothiazideNEDD4LPGXpeginterferon alfa-2a;peginterferon alfa-2b;ribavirinIFNL4PGX
allopurinolCYCSP5PGXdobutamineADRB1PGXpeginterferon alfa-2a;peginterferon alfa-2b;ribavirin;simeprevirIFNL4PGX
allopurinol;febuxostatAOX1PGXdocetaxelCYP3A4PGXpeginterferon alfa-2a;peginterferon alfa-2b;ribavirin;telaprevirIFNL3PGX
allopurinol;febuxostatUGT1A1;UGT1A10;UGT1A3;UGT1A4;UGT1A5;UGT1A6;UGT1A7;UGT1A8;UGT1A9PGXdocetaxelSLCO1B3PGXpeginterferon alfa-2a;peginterferon alfa-2b;ribavirin;telaprevirIFNL3;IFNL4PGX
alprazolamCYP3A;CYP3A4PGXdocetaxelVEGFAPGXpeginterferon alfa-2a;ribavirinSCARB1PGX
amantadine;Anticholinergics;Dopamine agonists;levodopa;selegilineSLC22A1PGXdocetaxel;doxorubicinAKR1C3PGXpeginterferon alfa-2a;ribavirinVDRPGX
amifampridineNAT2FDAdocetaxel;epirubicinMDM4PGXpeginterferon alfa-2bHLA-DPA1PGX
amifampridine phosphateNAT2FDAdocetaxel;FEC100;gemcitabine;trastuzumab;zoledronatePPCDCPGXpeginterferon alfa-2b;protease inhibitors;ribavirinSLC28A2PGX
amiloride;spironolactoneCYP4A11PGXdocetaxel;gemcitabine;paclitaxel;Platinum compounds;vinorelbineCASP7PGXpeginterferon alfa-2b;ribavirinITPAPGX
aminoglycoside antibacterialsMT-RNR1PGXdocetaxel;thalidomideCHST3PGXpemetrexedGGHPGX
amiodaroneNOS1APPGXdolasetron;granisetronNOS1APPGXpemetrexedMTHFRPGX
amiodarone;Antibiotics;antipsychotics;diuretics;quinidine;sotalolKCNE1PGXdolutegravirUGT1A1FDAperindoprilBDKRB1PGX
amisulprideMC4RPGXdolutegravirABCG2PGXperphenazineCYP2D6FDA
amisulpride;antipsychotics;olanzapine;quetiapine;risperidoneHTR1APGXdonepezilCYP2D6FDAPertussis vaccinesTLR4PGX
amisulpride;aripiprazole;clozapine;lithium;mirtazapine;olanzapine;paliperidone;quetiapine;risperidone;valproic acidSH2B1PGXdonepezilBCHEPGXphenazepamCYP2C19PGX
amitriptylineCYP2C19CPICdonepezilCHATPGXphenobarbitalABCB1PGX
amitriptylineCYP2D6CPICdonepezil;galantamine;rivastigmineCHATPGXphenobarbital;phenytoinMTHFRPGX
amitriptylineCYP2D6DPWGdonepezil;galantamine;rivastigmineCHRNA7PGXphenprocoumonVKORC1PGX
amitriptylineCYP2D6FDAdoxepinCYP2C19CPICphenytoinCYP2C9DPWG
amitriptyline;antidepressants;citalopram;fluvoxamine;paroxetine;sertraline;venlafaxineABCB1PGXdoxepinCYP2C19FDAphenytoinCFHR4PGX
amitriptyline;antidepressants;citalopram;paroxetine;venlafaxineABCB1PGXdoxepinCYP2D6CPICphenytoinSCN1APGX
amitriptyline;citalopram;fluoxetine;paroxetine;sertraline;venlafaxineABCB1PGXdoxepinCYP2D6DPWGphotodynamic therapyF13A1PGX
amitriptyline;citalopram;paroxetine;venlafaxineABCB1PGXdoxepinCYP2D6FDApimozideCYP2D6DPWG
amlodipineCYP3A4PGXdoxorubicinABCC1PGXpimozideCYP2D6FDA
amlodipine;chlorthalidoneNPPAPGXdoxorubicinCBR3PGXpioglitazoneADIPOQPGX
amlodipine;chlorthalidone;lisinoprilACEPGXdoxorubicin;doxorubicinolCBR1PGXpiroxicamCYP2C9CPIC
amlodipine;chlorthalidone;lisinoprilAGTPGXdoxorubicin;idarubicinCYBAPGXpiroxicamCYP2C9FDA
amodiaquineCYP2C8PGXdoxorubicin;methotrexate;prednisolone;vincristineABCB1PGXpitavastatinABCC2PGX
amodiaquine;pyrimethamine;sulfadoxineG6PDPGXdronabinolCYP2C9FDApitrakinraIL4RPGX
amoxapineCYP2D6FDADrug(s)GenePGXplatinumERCC5PGX
amoxicillin;clavulanateHLA-DQB1PGXDrugs For Treatment Of TuberculosisNAT2PGXPlatinum compoundsGSTP1PGX
amphetamineCYP2D6FDADrugs For Treatment Of Tuberculosis;isoniazidABCB1PGXPlatinum compoundsHSPA5PGX
amphetamineDRD2PGXDrugs For Treatment Of Tuberculosis;rifampinRIPOR2PGXPlatinum compoundsXRCC1PGX
amphetamine;cannabinoids;cocaine;opioidsKAT2BPGXDrugs used in alcohol dependenceGATA4PGXPlatinum compounds;radiotherapyPGX
amprenavirSLCO1B1PGXDrugs Used In DiabetesIRS1PGXPlatinum compounds;taxanesABCB1PGX
AnalgesicsKCNJ6PGXDrugs used in nicotine dependence;nicotineCHRNA3PGXpramipexoleDRD3PGX
Analgesics;Antiinflammatory agents, non-steroids;Ergot alkaloids;opioids;sumatriptanCOMTPGXDrugs used in nicotine dependence;nicotine;vareniclineCHRNA5PGXprasugrelCYP2C19PGX
Analgesics;Antiinflammatory agents, non-steroids;Ergot alkaloids;opioids;sumatriptanOPRM1PGXduloxetineNCAM1PGXpravastatinKIF6PGX
anastrozoleCYP19A1PGXduloxetineZNF385DPGXpravastatinSLCO1B1PGX
anastrozole;exemestaneMAP4K4PGXeculizumabC5PGXpravastatin;simvastatinHMGCRPGX
anastrozole;exemestane;letrozoleCYP19A1PGXeculizumabCR1PGXprednisone;tacrolimusABCB1PGX
anastrozole;letrozoleTNFRSF11BPGXefavirenzCYP2B6CPICpregabalinSLC7A5PGX
anastrozole;letrozoleTNFSF11PGXefavirenzCYP2B6DPWGprochlorperazineANKK1;DRD2PGX
angiotensin IIAGTR1PGXefavirenzCYP2B6FDApropafenoneCYP2D6DPWG
anthracyclines and related substancesCBR3PGXefavirenzCYP2B6PGXpropafenoneCYP2D6FDA
anthracyclines and related substancesHAS3PGXefavirenz;lopinavir;Nucleoside and nucleotide reverse transcriptase inhibitors;ritonavirPGXpropofolCYP2B6PGX
anthracyclines and related substances;cyclophosphamide;doxorubicin;epirubicin;fluorouracil;methotrexate;oxaliplatin;Platinum compoundsNOS3PGXefavirenz;nelfinavirABCB1PGXpropofol;remifentanilABCB1PGX
anthracyclines and related substances;taxanesABCB1PGXegfr inhibitorsEGFRPGXpropranololCYP2D6FDA
AntibioticsLGALS3PGXelagolixSLCO1B1FDApropranololADRB2PGX
antidepressantsHTR2APGXeliglustatCYP2D6DPWGprotriptylineCYP2D6FDA
antidepressantsSLC6A4PGXeliglustatCYP2D6FDAquetiapineCOMTPGX
antidepressants;antiepileptics;Beta Blocking Agents;calcium channel blockersACEPGXenalaprilPGXquetiapineMC4RPGX
antidepressants;antipsychotics;benzodiazepine derivatives;opioids;SympathomimeticsOPRM1PGXenalaprilACEPGXquinaprilAGTPGX
antidepressants;benzodiazepine derivatives;mirtazapine;Selective serotonin reuptake inhibitorsGALPGXenalapril;imidapril;lisinoprilBDKRB2PGXrabeprazoleCYP2C19FDA
antidepressants;citalopramCREB1;METTL21APGXendoxifenPGXradiotherapyCDK1PGX
antidepressants;citalopram;clomipramine;lithium;nefazodone;paroxetine;venlafaxineFKBP5PGXenfluraneCACNA1SPGXraloxifeneUGT1A8PGX
antidepressants;citalopram;escitalopram;fluoxetine;paroxetineTPH1PGXentacaponeCOMTPGXraltegravirUGT1A1FDA
antidepressants;citalopram;fluoxetineSERPINE1PGXEnzymesA2MPGXramiprilACEPGX
antidepressants;citalopram;fluvoxamine;paroxetine;sertraline;venlafaxineABCB1PGXephedrine;phenylephrineADRB2PGXranibizumabNRP1PGX
antidepressants;citalopram;paroxetineBDNFPGXepirubicin;fluorouracil;oxaliplatinNQO1PGXrasagilineDRD2PGX
antidepressants;desipramine;fluoxetineBDNFPGXerdafitinibCYP2C9FDAregadenosonAMPD1PGX
antidepressants;fluvoxamine;paroxetine;Selective serotonin reuptake inhibitors;sertralineHTR1APGXerlotinibEGFRPGXremifentanilCOMTPGX
antidepressants;mirtazapine;venlafaxineTPH2PGXerythromycinABCC2PGXremifentanil;sevofluraneABCB1PGX
antidepressants;Selective serotonin reuptake inhibitorsFKBP5PGXescitalopramCYP2C19CPICrepaglinideCYP2C8PGX
antidepressants;Selective serotonin reuptake inhibitors;venlafaxineGRIA3PGXescitalopramCYP2C19DPWGrepaglinideNEUROD1PGX
antiepilepticsABCB1PGXescitalopramCYP2C19FDArhodamine 123ABCB1PGX
antiepileptics;carbamazepineABCB1PGXescitalopramBMP5PGXrifampinNR1I2PGX
antiepileptics;carbamazepine;lamotrigine;oxcarbazepine;phenytoin;topiramateSCN2APGXescitalopramCYP1A2PGXrisperidoneCYP2D6DPWG
antiepileptics;carbamazepine;oxcarbazepineABCC2PGXescitalopram;nortriptylineBDNFPGXrisperidoneCYP2D6FDA
antiepileptics;carbamazepine;phenobarbital;phenytoin;valproic acidSCN2APGXesomeprazoleCYP2C19FDArisperidoneHTR2CPGX
AntihypertensivesATP2B1PGXesomeprazoleSTAT6PGXrisperidoneMC4RPGX
Antihypertensives And Diuretics In CombinationNOS3PGXestradiolPGXritodrineCACNA1CPGX
Antihypertensives;Antihypertensives And Diuretics In Combination;diureticsNOS3PGXetanerceptTNFPGXritonavirAPOC3PGX
Antihypertensives;Beta Blocking AgentsGRK5PGXethambutol;isoniazid;pyrazinamide;rifampinCYP2C9PGXrituximabFCGR3APGX
Antiinflammatory agents, non-steroidsCDKN2B-AS1PGXethanolADH1BPGXrivastigmineBCHEPGX
Antiinflammatory agents, non-steroidsPTGS1PGXethanolOPRM1PGXrocuroniumABCB1PGX
Antiinflammatory agents, non-steroids;aspirinPGXetoposideABCB1PGXrofecoxibPTGS2PGX
Antiinflammatory agents, non-steroids;celecoxib;diclofenacCYP2C9PGXetoposideSLIT1PGXrosiglitazonePAX4PGX
antineoplastic agentsSERPINA3PGXetravirineCYP2C19PGXrosuvastatinSLCO1B1FDA
antineoplastic agentsTP53PGXeverolimusPIK3R1PGXrosuvastatinABCG2PGX
antipsychoticsBDNFPGXeverolimusRPTORPGXrosuvastatinSLCO1B1PGX
antipsychoticsGRM3PGXexemestaneCYP19A1PGXsalbutamolADRB2PGX
antipsychotics;aripiprazole;bromperidol;chlorpromazine;clozapine;nemonapride;olanzapine;risperidoneDRD2PGXexemestane;letrozoleCYP19A1PGXsalbutamol;selective beta-2-adrenoreceptor agonistsCRHR2PGX
antipsychotics;aripiprazole;risperidoneANKK1PGXexemestane;letrozoleESR1PGXsalmeterolADRB2PGX
antipsychotics;chlorpromazine;fluphenazine;thioridazine;trifluoperazineCYP1A2PGXFarglitazar;glibenclamideSCNN1BPGXsalvianolic acid bNOS3PGX
antipsychotics;clozapine;olanzapineDRD2PGXfenofibrateAPOA5PGXselective beta-2-adrenoreceptor agonistsARG1PGX
antipsychotics;olanzapine;perphenazine;quetiapine;ziprasidoneRGS4PGXfenofibrateCRPPGXSelective serotonin reuptake inhibitorsHTR7PGX
antipsychotics;risperidoneLEPPGXfentanylABCB1PGXsertralineCYP2C19CPIC
antithymocyte globulinFCGR3APGXfentanylOPRM1PGXsertralineCYP2C19DPWG
Antithyroid PreparationsHLA-BPGXfentanyl;morphine;opioids;oxycodoneRHBDF2PGXsertralineGNB3;P3H3PGX
Antivirals for treatment of HIV infections, combinations;Drugs For Treatment Of TuberculosisABCB1PGXfentanyl;propofol;remifentanil;sevofluraneADRB2PGXsevofluraneCACNA1SPGX
Antivirals for treatment of HIV infections, combinations;ritonavirAPOEPGXfesoterodineCYP2D6FDAsibutramineGNB3PGX
apixabanABCG2PGXfexofenadineABCB1PGXsildenafilGNB3PGX
aripiprazoleCYP2D6DPWGfexofenadineSLCO2B1PGXsilibininABCB1PGX
aripiprazoleCYP2D6FDAflecainideCYP2D6DPWGsimvastatinSLCO1B1FDA
aripiprazoleDRD2PGXflecainideSCN4APGXsimvastatinHMGCRPGX
aripiprazole lauroxilCYP2D6FDAflecainide;mexiletineSCN4APGXsimvastatinSLCO1B1PGX
aripiprazole;clozapine;haloperidol;olanzapine;quetiapine;risperidoneFAAHPGXflecanideCYP2D6DPWGsimvastatin acidSLCO1B1PGX
aripiprazole;risperidoneDRD2PGXflibanserinCYP2C19FDAsiponimodCYP2C9FDA
artesunate;chlorproguanil;dapsoneG6PDPGXflucloxacillinNR1I2PGXsirolimusABCB1PGX
artesunate;primaquine;pyrimethamine;sulfadoxineG6PD;IKBKGPGXfluindioneVKORC1PGXsirolimus;temsirolimusNR1I2PGX
asparaginaseNFATC2PGXflunisolideTBXTPGXsitagliptin;vildagliptinGLP1RPGX
asparaginase;cyclophosphamide;cytarabine;daunorubicin;dexamethasone;doxorubicin;leucovorin;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristineGATA3PGXfluorouracilDPYDCPICSN-38UGT1A9PGX
asparaginase;cyclophosphamide;daunorubicin;prednisolone;vincristinePNPLA3PGXfluorouracilDPYDDPWGsofosbuvirIFNL3;IFNL4PGX
asparaginase;dexamethasone;methotrexatePYGLPGXfluorouracilDPYDFDAsofosbuvir;velpatasvir;voxilaprevirIFNL3;IFNL4PGX
aspirinPPARGPGXfluorouracilDPYDPGXsomatropin recombinantCOL1A1PGX
aspirin;Beta Blocking Agents;clopidogrel;hmg coa reductase inhibitorsNOS3PGXfluorouracil;FOLFIRI;FOLFOXTYMSPGXsorafenibKDRPGX
aspirin;clopidogrelITGA2PGXfluorouracil;FOLFOXTYMSPGXspironolactoneACEPGX
aspirin;clopidogrel;prasugrelPEAR1PGXfluorouracil;irinotecan;leucovorinABCG1PGXstavudineSAMHD1PGX
aspirin;prasugrelNTRK1;PEAR1PGXfluorouracil;irinotecan;leucovorinABCG2PGXsuccinylcholineCACNA1SPGX
atalurenCFTRPGXfluorouracil;leucovorin;oxaliplatinMTHFRPGXsuccinylcholineBCHEFDA
atazanavirUGT1A1CPICfluorouracil;oxaliplatinPARD3BPGXsuccinylcholine;volatile anestheticsRYR1PGX
atazanavirUGT1A2CPICfluorouracil;Platinum compounds;radiotherapyTMEM167A;XRCC4PGXsufentanilCOMTPGX
atazanavirUGT1A3CPICfluorouracil;Platinum compounds;radiotherapyXRCC4PGXsufentanilOPRM1PGX
atazanavirNR1I2PGXfluoxetineSLC6A4PGXsulfamethoxazoleGCLCPGX
atazanavirUGT1A1PGXfluoxetine;sertralineACEPGXsulfasalazineABCG2PGX
atazanavir;lopinavir;ritonavir;tenofovirABCC2PGXflurbiprofenCYP2C9FDAsulfinpyrazoneUGT1A9PGX
atazanavir;ritonavirUGT1A7PGXflurbiprofenCYP2C9PGXsulfonamides, urea derivativesTCF7L2PGX
atenololDPYSPGXfluticasone propionate;montelukastCA10PGXsulindacFMO3PGX
atenololGNB3PGXfluvastatinACEPGXsumatriptanGNB3PGX
atenolol;bisoprololPGXfluvastatinCETPPGXsunitinibABCB1PGX
atenolol;hydrochlorothiazideALDH1A2PGXfluvastatinSLCO1B1PGXsunitinibFLT3PGX
atenolol;hydrochlorothiazide;metoprololSLC25A31PGXfluvastatin;simvastatinLIPCPGXtacrolimusCYP3A5CPIC
atenolol;irbesartanEDN1PGXfluvoxamineCYP2B6CPICtacrolimusCYP3A5FDA
atenolol;metoprololADRB2PGXfluvoxamineCOMTPGXtacrolimusCYP3A4PGX
atenolol;verapamilCACNA1CPGXfluvoxamineFGF2PGXtalinololABCB1PGX
atomoxetineCYP2D6CPICfluvoxamineHTR2APGXtamoxifenCYP2D6CPIC
atomoxetineCYP2D6DPWGfluvoxamineCYP2D6FDAtamoxifenCYP2D6DPWG
atomoxetineCYP2D6FDAfluvoxamine;milnacipran;paroxetineHTR1APGXtamoxifenCYP2D6FDA
atomoxetineSLC6A2PGXfluvoxamine;paroxetineHTR2APGXtamoxifenCYP19A1PGX
atorvastatinAPOEPGXfolic acidMTHFRPGXtamoxifenUGT1A4PGX
atorvastatinSLCO1B1PGXfolic acid;methotrexateTLR4PGXtamsulosinCYP2D6FDA
atorvastatin;BisphosphonatesFDPSPGXfolic acid;vitamin b-complex, plainMTHFRPGXtaxanesPGX
atorvastatin;fluvastatin;hmg coa reductase inhibitors;lovastatin;pravastatin;simvastatinHMGCRPGXfolic acid;vitamin b-complex, plainMTRRPGXtegafurDPYDDPWG
atorvastatin;hmg coa reductase inhibitors;pravastatin;simvastatinHTR7PGXfollitropin beta;thyrotropin alfa;urofollitropinFSHRPGXtegafurDPYDPGX
atorvastatin;hmg coa reductase inhibitors;rosuvastatinCOQ2PGXforskolinABCB1PGXtelaprevirCYP24A1PGX
atorvastatin;lovastatin;simvastatinAPOA5PGXfurosemideABCC4PGXtelmisartanGNB3PGX
atorvastatin;pravastatin;simvastatinABCA1PGXfurosemide;spironolactoneADD1PGXtelmisartanSLCO1B3PGX
atorvastatin;quinaprilACEPGXgabapentinSLC7A5PGXtemozolomideABCB1PGX
atorvastatin;rifampinSLCO1B1PGXgalantamineCYP2D6FDAtenofovirABCC4PGX
atorvastatin;simvastatinPON1PGXgalantamineCHATPGXtenofovir disoproxil fumarateCYP27B1PGX
atorvastatin;simvastatinRYR2PGXgefitinibCYP2D6FDAtenoxicamCYP2C9CPIC
avatrombopagCYP2C9FDAgefitinibABCB1PGXterbutalineADRB2PGX
axitinib;sorafenibHIF1APGXgefitinibEGFRPGXtetrabenazineCYP2D6FDA
azathioprineNUDT15CPICgeldanamycinEGFRPGXthalidomideERCC1PGX
azathioprineNUDT15DPWGgemcitabineNT5C2PGXThiazides, plainGNB3PGX
azathioprineTPMTCPICgemcitabineRRM1PGXthiazolidinedionesAQP2PGX
azathioprineTPMTDPWGgemcitabine;paclitaxelCDAPGXthioguanineNUDT15CPIC
azathioprineTPMTFDAgemcitabine;paclitaxelSLC29A1PGXthioguanineTPMTCPIC
azathioprineFTOPGXgemcitabine;Platinum compoundsCASP7PGXthioguanineTPMTDPWG
azathioprineNUDT15PGXgemcitabine;Platinum compoundsRRM1PGXthioguanineTPMTFDA
azathioprine;mercaptopurinePGXgemtuzumab ozogamicinCD33PGXthioridazineCYP2D6FDA
azathioprine;mercaptopurine;thioguanineNUDT15PGXglatiramer acetatePGXthioridazineCYP2D6PGX
azathioprine;purine analoguesITPAPGXglibenclamideNOS1APPGXthiotepaGSTP1PGX
belinostatUGT1A1FDAgliclazideKCNJ11PGXtianeptineOPRM1PGX
benazeprilMTHFRPGXglimepirideNOS1APPGXticagrelorPEAR1PGX
benazepril;imidaprilAGTPGXglipizideNOS1APPGXtimololPGX
benazepril;perindoprilACEPGXglucocorticoidsHSD3B1PGXtiotropiumADRB2PGX
Beta Blocking AgentsADRB1PGXgranisetronABCB1PGXtipifarnibABCB1PGX
Beta Blocking AgentsGRK5PGXgranisetron;palonosetronERCC1PGXtipiracil hydrochloride;trifluridineSLC29A1PGX
Beta blocking agents, selectiveBST1PGXhaloperidolCYP2D6DPWGtocilizumabIL6RPGX
bevacizumabARMS2PGXhaloperidolMC4RPGXtolbutamideCYP2C9PGX
bevacizumabCFHPGXhaloperidolSLC6A5PGXtolterodineCYP2D6FDA
bevacizumabCXCR4PGXhalothaneCACNA1SPGXtopiramateGRIK1PGX
bevacizumabEDN1PGXhdl cholesterol;letrozole;triglyceridesCYP19A1PGXtopotecanABCG2PGX
bevacizumab;capecitabine;cetuximab;oxaliplatinMGAT4APGXHepatitis vaccinesIL4RPGXtramadolCYP2D6DPWG
bevacizumab;capecitabine;fluorouracil;irinotecan;leucovorin;oxaliplatinVEGFAPGXheroinOPRM1PGXtramadolCYP2D6FDA
bevacizumab;capecitabine;oxaliplatinMGAT4APGXheroinSOD2PGXtramadolOPRM1PGX
bevacizumab;carboplatin;cisplatin;cyanocobalamin;folic acid;pemetrexedMTHFRPGXheroin;methamphetamineBDNFPGXtrandolapril;verapamilPTPRDPGX
bevacizumab;fluorouracil;irinotecan;leucovorinSHMT1PGXheroin;opioidsOPRM1PGXtrastuzumabERBB2PGX
bevacizumab;pegaptanib;ranibizumabVEGFAPGXhighly active antiretroviral therapy (haart)OPRM1PGXtrastuzumabFCGR2APGX
bevacizumab;pemetrexedGGHPGXhmg coa reductase inhibitorsLPAPGXtriamcinoloneHCG22PGX
bevacizumab;ranibizumabVEGFAPGXhmg coa reductase inhibitorsSLCO1B1PGXtrimipramineCYP2C19CPIC
bilirubinUGT1APGXhmg coa reductase inhibitors;letrozoleCYP19A1PGXtrimipramineCYP2D6CPIC
bisantreneABCB1PGXhmg coa reductase inhibitors;simvastatinGATMPGXtrimipramineCYP2D6FDA
bisoprololACY3PGXhormonal contraceptives for systemic useF5PGXtroglitazonePGX
BisphosphonatesABCC4PGXHydralazine-isosorbide dinitrateGNB3PGXtropisetronCYP2D6CPIC
BisphosphonatesFDPSPGXhydrochlorothiazideADD1PGXTumor necrosis factor alpha (TNF-alpha) inhibitorsIL23RPGX
Bisphosphonates;clodronate;etidronic acid;risedronate;tiludronateIL1BPGXhydrochlorothiazideKCNJ1PGXTumor necrosis factor alpha (TNF-alpha) inhibitorsTNFPGX
Bisphosphonates;pamidronate;zoledronateCYP2C8PGXhydrocodoneOPRM1PGXTumor necrosis factor alpha (TNF-alpha) inhibitors;ustekinumabIL1BPGX
bleomycin;cisplatin;etoposideBLMHPGXhydroxyureaMAP3K5PGXustekinumabTIRAPPGX
bleomycin;cisplatin;etoposideGSTP1PGXibuprofenPTGS2PGXvalbenazineCYP2D6FDA
bleomycin;cyclophosphamide;doxorubicin;prednisone;rituximab;vincristine;vindesineABCB1PGXidarubicinNCF4PGXvalganciclovirABCB1PGX
boceprevir;peginterferon alfa-2a;peginterferon alfa-2b;ribavirinIFNL3;IFNL4PGXidarubicinRAC2PGXvalproic acidPOLGPGX
bortezomib;dexamethasone;melphalan;prednisoneCTLA4PGXiloperidoneCYP2D6FDAvalproic acidUGT1A6PGX
botulinum toxin type aTRPV1PGXiloperidoneCYP2D6PGXvancomycinPGX
brexpiprazoleCYP2D6DPWGimatinibCYP2B6PGXvardenafilCYP3A5PGX
brexpiprazoleCYP2D6FDAimatinibEGFRPGXvareniclineCHRNA4PGX
brivaracetamCYP2C19FDAimatinibSLC22A1PGXvenlafaxineCYP2D6DPWG
bucindololADRB1PGXimatinibSLC22A4PGXvenlafaxineCYP2D6FDA
budesonidePGXimipramineCYP2C19CPICvenlafaxineHTR2APGX
budesonide;flunisolide;fluticasone propionate;glucocorticoids;nedocromil;triamcinoloneGLCCI1PGXimipramineCYP2C19DPWGverapamilKCNIP1;KCNMB1PGX
bufuralol;dextromethorphanCYP2D6PGXimipramineCYP2D6CPICvincristineABCB1PGX
bumetanide;furosemide;torasemideSLC12A3PGXimipramineCYP2D6DPWGvincristineCEP72PGX
buprenorphineCOMTPGXimipramineCYP2D6FDAvitamin eCYP4F2PGX
buprenorphineOPRD1PGXimiquimodTLR7PGXVitamin KCYP4F2PGX
buprenorphine;fentanyl;meperidine;morphine;opioids;pentazocinePGXindinavirCYP3A4PGXvoriconazoleCYP2C19CPIC
buprenorphine;fentanyl;tramadolCOMTPGXindinavirUGT1A1PGXvoriconazoleCYP2C19DPWG
bupropionGALR1PGXinfliximabTNFPGXvoriconazoleCYP2C19FDA
bupropion;Drugs used in nicotine dependence;nicotine;vareniclineCHRNA5PGXinfliximab;Tumor necrosis factor alpha (TNF-alpha) inhibitorsTNFRSF1BPGXvoriconazoleCYP3A4PGX
bupropion;nicotineDRD1PGXinsulin recombinant;zinc acetateSLC30A8PGXvortioxetineCYP2D6FDA
bupropion;nicotine;vareniclineCHRNA5PGXinterferon alfa-2a, recombinant;interferon alfa-2b, recombinant;ribavirinFTOPGXwarfarinCYP2C9DPWG
busulfanCYP2C9PGXinterferon alfa-2a, recombinant;peginterferon alfa-2bIDO1PGXwarfarinCYP2C9FDA
busulfan;cyclophosphamideCTHPGXinterferon alfa-2b, recombinant;ribavirinITPAPGXwarfarinCYP4F2FDA
butorphanolCOMTPGXinterferon beta-1aRORAPGXwarfarinVKORC1FDA
caffeineADORA2APGXinterferon beta-1a;interferon beta-1bHLA-DQA1PGXwarfarinPGX
caffeineCYP1A2PGXinterferon beta-1a;interferon beta-1bIRF6PGXwarfarinCYP4F2PGX
calceinABCB1PGXinterferonsIFNL3;IFNL4PGXwarfarinVKORC1PGX
calcein;lopinavirABCC2PGXinterferonsSTAT3PGXXK469AOX1PGX
calciumVDRPGXinterferons;peginterferon alfa-2a;peginterferon alfa-2b;ribavirinIFNL3PGXzileutonPRORPPGX
calcium channel blockersCACNA1CPGXinterferons;ribavirinIL18PGXzoledronateFDPSPGX
calcium channel blockers;nitrendipineKCNH2PGXirbesartanCYP2C9PGXzuclopenthixolCYP2D6DPWG
candesartanAGTR1PGXirinotecanUGT1A1DPWG
cangrelorP2RY12PGXirinotecanUGT1A1FDA
cannabinoidsFAAHPGXirinotecanUGT1A1PGX
cannabinoids;cocaine;ethanol;nicotine;opioidsOPRM1PGXirinotecan;raltitrexedTYMSPGX
capecitabineDPYDCPICisofluraneCACNA1SPGX
capecitabineDPYDFDAisoniazidBACH1PGX
capecitabineDPYDPGXisoniazid;phenytoinNAT2PGX
capecitabineTYMSPGXisoniazid;pyrazinamide;rifampinNAT2PGX
capecitabine;docetaxelCYP1A1PGXisoniazid;rifampinGSTP1PGX
capecitabine;epirubicin;platinumGSTP1PGXisoproterenolADRB2PGX
capecitabine;fluorouracilHLA-GPGXivacaftorCFTRPGX
capecitabine;fluorouracil;leucovorin;oxaliplatinMTHFRPGXivacaftor-lumacaftorCFTRPGX
capecitabine;fluorouracil;tegafurTYMSPGXivacaftor-tezacaftorCFTRPGX
capecitabine;oxaliplatinPTGS2PGXketorolacPGX
capecitabine;radiotherapyAREGPGXl-methylfolate;Vitamin B-complex, Incl. CombinationsMTHFRPGX
captoprilACEPGXl-phenylalaninePAHPGX
carbamazepineHLA-ACPICl-tryptophanSLC22A2PGX
carbamazepineHLA-AFDAlamivudine;lopinavir;ritonavir;zidovudineABCB1PGX
carbamazepineHLA-BCPIClamotrigineUGT1A4PGX
carbamazepineHLA-BFDAlansoprazoleCYP2C19CPIC
carbamazepineCYP3A5PGXlansoprazoleCYP2C19DPWG
carbamazepineSCN1APGXlansoprazole;omeprazole;rabeprazoleIL1BPGX
carbamazepine;clobazam;ethosuximide;lamotrigine;levetiracetam;oxcarbazepine;valproic acidSCN1APGXlansoprazole;tacrolimusABCB1PGX
carbamazepine;oxcarbazepineSCN1APGXlapatinibHLA-DQA1FDA
carbamazepine;phenobarbital;phenytoin;valproic acidCYP1A1PGXlapatinibHLA-DRB1FDA
carbamazepine;phenytoin;valproic acidGABRA1PGXlatanoprostABCC4PGX
carbocisteinePAHPGXledipasvir;sofosbuvirIFNL3;IFNL4PGX
carboplatin;cisplatinEIF3APGXleflunomideESR1PGX
carboplatin;cisplatin;docetaxel;erlotinib;gefitinib;paclitaxelMAP3K1PGXlenalidomide;thalidomideCTNNB1PGX
carboplatin;cisplatin;docetaxel;gemcitabine;paclitaxelRAF1PGXletermovirSLCO1B1PGX
carboplatin;cisplatin;docetaxel;paclitaxelPGXletrozoleESR1PGX
carboplatin;cisplatin;fluorouracilSLC19A1PGXlevodopaHOMER1PGX
carboplatin;cisplatin;gemcitabineGPX5PGXlevodopaSLC6A3PGX
carboplatin;cisplatin;oxaliplatin;platinum;Platinum compoundsERCC1PGXliraglutideGLP1RPGX
carboplatin;cyclophosphamide;thiotepaALDH1A1PGXlisinoprilACEPGX
carboplatin;docetaxel;paclitaxelBCL2PGXlithiumASIC2PGX
carboplatin;docetaxel;trastuzumabERBB3PGXlithium;valproic acidPGX
carboplatin;gemcitabineCYP2C8PGXlofexidineCYP2D6FDA
carboplatin;lonafarnib;paclitaxelFNTBPGXlopinavirSLCO1B1PGX
carboplatin;paclitaxelMAD1L1PGXlorazepamUGT2B15PGX
carboplatin;paclitaxelSLCO1B3PGXlosartanSTK39PGX
carboplatin;taxanesGSRPGXlovastatinLDLRPGX
carisoprodolCYP2C19FDAlovastatin acidSLCO1B1PGX
carvedilolCYP2D6FDAlumacaftorCFTRPGX
carvedilolADRB2PGXlumefantrineCYP3A4PGX
catecholaminesADRB1PGXlurasidoneHTR1APGX
catecholamines;metforminSLC22A3PGXMeasles vaccinesTLR3PGX
cavosonstatCFTRPGXmeclizineCYP2D6FDA
cefotaximeSLC22A8PGXmeloxicamCYP2C9CPIC
ceftriaxoneABCG2PGXmelphalanSLC7A5PGX
celecoxibCYP2C9FDAmemantineNR1I2PGX
celecoxibALOX12PGXmephenytoinCYP2C19PGX
cerivastatinSLCO1B1PGXmercaptopurineNUDT15CPIC
cetuximabEGFPGXmercaptopurineTPMTCPIC
cetuximab;irinotecan;leucovorin;tegafurEGFRPGXmercaptopurineTPMTFDA
cetuximab;irinotecan;panitumumabAREGPGXmercaptopurineFTOPGX
cetuximab;panitumumabKRASPGXmercaptopurineNUDT15PGX
cevimelineCYP2D6FDAmercaptopurine;methotrexateITPAPGX
chlorothiazide;hydrochlorothiazidePGXmetforminSLC22A1PGX
chlorpromazine;clozapine;haloperidol;olanzapine;quetiapine;risperidone;trifluoperazineEPM2APGXmetforminSLC47A1PGX
chlorthalidone;lisinoprilMMP3PGXmetformin;sulfonamides, urea derivativesKCNJ11PGX
cisplatinACYP2PGXmethacholineADRB2PGX
cisplatinERCC1PGXmethadoneABCB1PGX
cisplatin;cyclophosphamideCYP2E1PGXmethadoneCYP3A4PGX
cisplatin;cyclophosphamideGSTM3PGXmethamphetamineFAAHPGX
cisplatin;cyclophosphamide;doxorubicin;methotrexate;vincristineABCC3PGXmethotrexateATICPGX
cisplatin;fluorouracilGALNT14PGXmethotrexateMTHFRPGX
cisplatin;fluorouracil;mitoxantroneGALNT14PGXmethotrexateSLC19A1PGX
cisplatin;fluorouracil;oxaliplatinVEGFAPGXmethoxyfluraneCACNA1SPGX
cisplatin;fluorouracil;radiotherapyMUTYHPGXmethylphenidateCES1PGX
cisplatin;gemcitabineRRM1PGXmethylphenidateDRD2PGX
cisplatin;irinotecanUBE2IPGXmethylphenidateSLC6A2PGX
cisplatin;oxaliplatin;Platinum compoundsGSTP1PGXmethylprednisolone;prednisoloneABCB1PGX
cisplatin;oxaliplatin;platinum;Platinum compoundsERCC2;KLC3PGXmetoclopramideCYP2D6FDA
cisplatin;pemetrexedABCC2PGXmetoprololCYP2D6DPWG
citalopramCYP2C19CPICmetoprololCYP2D6FDA
citalopramCYP2C19DPWGmetoprololADRB1PGX
citalopramCYP2C19FDAmidazolamPORPGX
citalopramHTR2APGXmigalastatGLAPGX
citalopram;escitalopramPGXmilnacipranHTR1APGX
citalopram;fluoxetineGSK3BPGXmirabegronCYP2D6FDA
citalopram;fluoxetine;paroxetine;sertralineREEP5PGXmirtazapineFKBP5PGX
cladribine;cytarabineRRM1PGXmirtazapine;venlafaxineTPH2PGX
cladribine;fluorouracil;gemcitabineNT5C1APGXmitotaneCYP2B6PGX
clobazamCYP2C19FDAmivacuriumBCHEFDA
clodronateVDRPGXmodafinilABCB1PGX
clomipramineCYP2C19CPICmontelukastLTA4HPGX
clomipramineCYP2C19DPWGmorphineKCNJ6PGX
clomipramineCYP2D6CPICmorphineOPRM1PGX
clomipramineCYP2D6DPWGmorphine;nortriptylineABCB1PGX
clomipramineCYP2D6FDAmuraglitazarEDN1PGX
clomipramine;liothyronine;lithium;nefazodone;venlafaxineHTR1BPGXmycophenolate mofetilSLCO1B3PGX
clomipramine;lithium;nefazodone;paroxetine;venlafaxineABCB1PGXmycophenolic acidSLCO1B3PGX
clomipramine;nefazodone;paroxetine;venlafaxineFKBP5PGXnaloxoneOPRM1PGX
clonidineGNB3PGXnaltrexoneDBHPGX
clopidogrelCYP2C19CPICnaproxenCYP2C9PGX
clopidogrelCYP2C19DPWGnateglinideSLCO1B1PGX
clopidogrelCYP2C19FDAnebivololCYP2D6FDA
clopidogrelCES1PGXnelfinavirCYP2C19PGX
clozapineCYP2D6FDAnemonaprideANKK1PGX
clozapineABCB1PGXnevirapineCYP2B6PGX
clozapineHTR2CPGXnicotineCHRNA3PGX
clozapineNTRK2PGXnicotineCHRNA5PGX
clozapine;olanzapineMC4RPGXnicotine;Opium alkaloids and derivativesCHRNA5PGX
clozapine;olanzapine;risperidoneDRD2PGXnifedipineSLC14A2PGX
cocaineDRD2PGXnilotinibUGT1A1FDA
cocaineOPRM1PGXnimodipineCACNA1CPGX
cocaine;ethanol;nicotineOPRM1PGXnitrendipineAGTR1PGX
cocaine;heroinOPRM1PGXnitroprussideACEPGX
codeineCYP2D6CPICnitrous oxideMTHFRPGX
codeineCYP2D6DPWGnortriptylineCYP2D6CPIC
codeineCYP2D6FDAnortriptylineCYP2D6DPWG
codeineOPRM1PGXnortriptylineCYP2D6FDA
conjugated estrogensSULT1A1PGXnortriptylineABCB1PGX
conjugated estrogens;medroxyprogesteroneVDRPGXnortriptylineGNB3PGX
corticosteroidsBCL2L11PGX
corticosteroidsCRHR1PGX
corticosteroids;selective beta-2-adrenoreceptor agonistsADRB2PGX
cotinineCHRNA5PGX
cotinine glucuronideUGT1A9PGX
cotinine;nicotineOPRM1PGX
coumarinCYP2A6PGX
creatineMOBPPGX
curcumin;ivacaftorCFTRPGX
cyclophosphamideABCC4PGX
cyclophosphamideCYP2C19PGX
cyclophosphamideSOD2PGX
cyclophosphamide;cytarabine;daunorubicin;mercaptopurine;methotrexate;prednisone;vincristineDROSHAPGX
cyclophosphamide;dexamethasone;lenalidomide;thalidomideCTNNB1PGX
cyclophosphamide;docetaxelVEGFAPGX
cyclophosphamide;docetaxel;doxorubicin;epirubicin;fluorouracilSLCO1B1PGX
cyclophosphamide;doxorubicinCYP2C19PGX
cyclophosphamide;doxorubicin;fluorouracilATMPGX
cyclophosphamide;doxorubicin;fluorouracilSLC22A16PGX
cyclophosphamide;doxorubicin;fluorouracil;methotrexateNOS3PGX
cyclophosphamide;doxorubicin;prednisone;rituximab;vincristineGSTA1PGX
cyclophosphamide;epirubicinGSTP1PGX
cyclophosphamide;epirubicin;fluorouracilNQO1PGX
cyclophosphamide;epirubicin;fluorouracilPIGBPGX
cyclophosphamide;epirubicin;paclitaxelCYP1B1PGX
cyclophosphamide;fluorouracil;methotrexateFGFR4PGX
cyclosporineCYP3A4PGX
cyclosporineCYP3A5PGX
cyclosporine;dicloxacillinABCB1PGX
cyclosporine;mycophenolate mofetilIL10PGX
cyclosporine;mycophenolate mofetil;sirolimus;tacrolimusUGT1A8PGX
cyclosporine;mycophenolic acidABCC2PGX
cyclosporine;sirolimus;tacrolimusTCF7L2PGX
cyclosporine;tacrolimusCRTC2PGX
cysteamineCFTRPGX
cytarabineCDAPGX
cytarabine;daunorubicin;dexrazoxane;idarubicinABCB1PGX
cytarabine;daunorubicin;etoposide;mitoxantroneSLCO1B1PGX
cytarabine;fludarabine;gemtuzumab ozogamicin;idarubicinCYP2E1PGX
cytarabine;idarubicinNT5C3APGX

Summary

There you have it! With information, free is not always good and useful. A lot of users come to Xcode after having tried Promethease for $5. If you just want to satisfy your curiosity and not really looking for anything specific, then Promethease may be the way to go. But, if you want specific, organized and actionable insights from your genetic data about your health and wellbeing, then you certainly must try the Xcode Health reports!!

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