Folate (Vitamin B9) is also known as folic acid or folate. "Folic" is derived from the word "folium," meaning leaves, as in green leafy vegetables. Needless to say, leaves are one of the richest sources of vitamin B9.
The vitamin B9 we eat is absorbed in the jejunum region of the small intestine after going through minor structural changes.
In most cases, dietary sources of vitamin B9 are sufficient to meet this nutrient's requirement. Other than the leafy greens, some foods rich in vitamin B9 are beans, whole grains, seafood, peanuts, and sunflower seeds.
The Recommended Dietary Allowance or RDA for folate is 400 mcg/day for healthy adults. The RDA for lactating and pregnant women are 500 and 600 mcg/day, respectively.
Folate deficiency in pregnant women is one of the leading causes of neural tube defects, a birth abnormality, in babies.
Symptoms of vitamin B9 deficiency include extreme tiredness, pale skin, headaches, and heart palpitations.
Vitamin B9 needs to be converted into a form called tetrahydrofolate or THF to be effectively used by the body. The conversion of folic acid to THF is carried out by an enzyme called THF reductase.
This conversion is a very crucial step in the MTHFR cycle.
THF plays a very important role in converting a harmful amino acid called homocysteine to a safe and useful amino acid called methionine.
Image: Folate Cycle
The MTHFR gene is a well-known gene associated with folate deficiency. This gene helps the conversion of inactive vitamin B9 such as folate, or folic acid, to active B9, the THF.
30-60% of people have a change in this gene that ultimately leads to low vitamin B9 levels in the body.
Other genes like MTYL1 also influence your vitamin B9 levels.
Fortunately, vitamin B9 deficiency comes with a simple fix - increasing your dietary folate intake. In some cases, folate supplements may be advised.
A simple genetic test can reveal your genetic status of vitamin B9 deficiency.
Most genetic tests provide your DNA information in the form of a text file called the raw DNA data. This data may seem like Greek and Latin to you.
At Xcode Life, can help you interpret this data. Upload your raw data and order a nutrition report. Xcode Life then analyzes your raw data in detail to provide you with comprehensive nutrition analysis, including information on your vitamin B9 requirements.
The natural forms of this nutrient in our body are selenocysteine and selenoproteins. Humans are known to have 25 selenoproteins, with selenoprotein P and glutathione peroxidase (GPx) among the most studied. Most of the selenoproteins found in the body play a role in antioxidant function.
Most of the selenoproteins found in the body play a role in antioxidant function.
Some other important functions of selenoproteins include:
The inorganic (chemically-derived) forms of selenium are available as selenide, selenite, and selenium. Selenium is taken up from the soil by plants, so dietary levels depend upon the soil's selenium content.
From an evolutionary point of view, humans adapted to selenium needs based on their geographical location. During early human migration, they inhabited areas with differences in the soil levels of certain micronutrients, like selenium.
Over the years, the body learned to adapt itself to the selenium availability in the soil. Thus, the soil concentration, along with the dietary practices of different populations, brought about the differences in the selenium requirements.
While selenium is very important for its function as a selenoprotein, it was essential to regulate blood levels of selenium to reduce the risk of selenium toxicity in areas with high environmental selenium levels.
Some types of genes involved in selenium uptake and metabolism helped adapt to the environmental levels of selenium. For example, in regions with low selenium levels in the soil, people with higher/better absorption of selenium from the diet may have had a survival advantage.
On the other hand, regions of high selenium levels, people with lower absorption levels may have had an advantage.
The RDA of selenium for a healthy adult is 55 µg/ day, while the normal blood levels are between 70 to 150 ng/mL.
The CBS gene carries the instructions to make the enzyme cystathionine beta-synthase. This enzyme is responsible for converting a harmful amino acid, homocysteine, to another amino acid, cysteine, which is safe for the body.
Some changes to the CBS gene play a role in the build-up of homocysteine in the body, causing many negative health implications.
It also leads to lower selenium levels in the body.
According to a study, selenium levels are inversely associated with homocysteine levels - higher levels of homocysteine in the body lead to lower selenium levels.
Thus, the changes in the CBS gene that bring about the buildup of homocysteine can also cause selenium deficiency.
rs6586282 is located on the CBS gene and regulates serum homocysteine and selenium levels. 85% of the people have a normal type of the CBS gene, while 15% have the type that could put them at risk for selenium deficiency. The T allele affects the clearance of homocysteine and causes its build-up, and is hence associated with lower levels of selenium in the body.
The amount of selenium present in food sources is largely influenced by soil quality and other factors like rainfall and evaporation.
Selenium deficiency can result in several health issues like:
Selenium toxicity: While selenium supplementation is very important for people with selenium deficiency, excess selenium can lead to a condition known as selenium toxicity. The safer upper limit for selenium is 400 micrograms a day for healthy adults. Anything above that could lead to toxicity, characterized by symptoms like fatigue, discoloration of the nail, brittleness, irritability, and garlic breath. Long-term or chronic toxicity can lead to loss of fertility and hypothyroidism.
Selenium deficiency can be assessed by a qualified healthcare practitioner based on symptoms. Levels of the enzyme glutathione peroxidase may also be tested. This enzyme is known to play a role in selenium functioning. Low levels of the enzyme indicate low levels of selenium.
An infection by a virus is known to increase reactive oxygen species or ROS and lower antioxidant enzyme levels in the body. Reactive oxygen species are molecules containing oxygen, which react with other molecules in the body cells. This could lead to oxidative stress damage, resulting in increased viral replication.
Selenium increases type 1 immunity against viral infections and restricts viral mutations. Viruses undergo changes to adapt to the human body better and escape any treatment against it.
Identifying people at risk of selenium deficiency and supplementing their need may help in its use as adjuvant therapy (an add-on therapy other than the primary treatment) to treat viral infections.
RSV or respiratory syncytial virus is a type of virus that causes respiratory infection with cold or flu-like symptoms. A study conducted on 75 children with respiratory diseases due to RSV showed the selenium supplementation helped relieve the symptoms faster.
Recent research also found an association between selenium supplementation and SARS-COV-II viral multiplication.
Selenium influences the chemicals that are known to play an important role in affecting mood and behavior in animals and humans. Thus, this nutrient is required for the brain's normal functioning. Selenoprotein P (SELENOP) plays a role in the transport of this trace mineral in the body.
Selenium supplementation plays a role in improving mood-related issues. In a study conducted by Benton and Cook, 100mcg of selenium was given to the study population, while controls were given a placebo. The study found that supplementation with selenium resulted in an improvement in the mood.
In another study by Gosney et al., micronutrient supplementation and its effect on the mood of nursing home residents were studied. Eight weeks after supplementation with 60 mcg of selenium, there was a reduction in depression scores.
As selenium affects cognitive function, a deficiency in selenium levels can play a role in memory problems, lack of mental acuity (sharpness), or (in non-clinical terms) brain fog.
Preeclampsia is a condition in which pregnant mothers have high blood pressure, potentially affecting their pregnancy. A study on nearly 500 women showed that supplementation with selenium resulted in a 72% reduction in preeclampsia risk compared with controls.
A study conducted on mother and child to understand the impact of selenium on psychomotor function (the relationship between physical actions and cognitive function) showed that maternal selenium levels during the first trimester (in pregnancy) play a role in motor development during the child's first year.
The same study showed that the level of selenium in cord blood (blood in the tube that connects the mother to the baby) had a positive relationship with the child's language development at two years.
The selenium levels in the food are influenced by selenium levels in the soil. Soil selenium levels may be affected by pH, rainfall, and evaporation. People with the following conditions may have lower selenium levels:
The primary step towards adequate levels of selenium is to eat foods rich in selenium. The National Institute of Health recommends that 55µg of selenium should be consumed every day by people over the age of 14.
Selenium is an important mineral required for many processes like the regulation of the thyroid gland and anti-inflammatory activities. The body cannot produce selenium, and hence it needs to be consumed through dietary sources. For selenium to perform its function, it needs to be absorbed and utilized well by the body. Some genetic factors can put you at risk for selenium deficiency, which can lead to a weakened immune system, muscle pain, and hair loss. Health conditions like HIV and Crohn’s disease can also put you at risk for selenium deficiency. Ensuring adequate intake of selenium is important for the body. Some common food sources include rice, beans, wheat bread, and tuna.
[idea]Folate (vitamin B9, folic acid) is essential for life-sustaining processes of DNA synthesis, replication, and repair and they are naturally present in common foods such as black eyed peas, liver, asparagus, beets, brussels sprouts, and spinach. Folate levels have been associated with birth defects, cardiovascular disease , and many other important healthcare issues . Individuals differ in their ability to metabolise folate, depending on the type of MTHFR gene that they carry. This article will tell you how you can protect your body and mitigate the influence of your genes by making proper food choices.[/idea]
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Methyl folate is essential for the proper function of almost all of the body’s systems and it is involved in the conversion of an amino acid homocysteine into methionine. When you eat foods containing folate, MTHFR ( Methylene Tetra Hydrofolate Reductase) enzyme in your body converts it into methylfolate, an active form of folate. MTHFR enzyme is produced by the MTHFR gene. If you have two “normal” copies of this gene, then you produce fully functioning enzyme, if you have one “normal” copy, the enzyme function is reduced and if you have no “normal” copies, then the function is reduced even further.
If you carry a type “TT” (abnormal) of the MTHFR gene, it leads to lower levels of folate in the blood & reduced enzyme activity, results in elevated levels of homocysteine in the body . Elevated homocysteine level is an independent risk factor of cardiovascular diseases among Indians.
Individuals who carry one copy of the abnormal T-type of the gene can still metabolize folate normally when compared to individuals carrying two copies of the abnormal TT-type of the gene and they are at a higher risk for (hyperhomocysteinemia (elevated levels of homocysteine) in their body.
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The American Heart Association advocates a supplement regimen of 400 μg of folic acid, 2 mg of vitamin B6, and 6 μg of vitamin B12, if an initial trial of a folate-rich diet is not successful in adequately lowering homocysteine concentrations.
In addition, get your homocysteine levels measured. High homocysteine levels indicate that you may have a methylation issue or folate deficiency.
Want to know more about MTHFR gene, Xcode’s nutrigenetics test can tell you what versions of the MTHFR gene you have in your DNA. You can also learn about how your genes may influence other traits, including your risk for certain diseases. You can write to us at email@example.com.