1. How to read your Promethease report?

To read your Promethease review report you will need to ensure that you are accustomed to some of the terms that are found in their report like magnitude and repute. It is difficult to sift through thousands of pages in your report. Once you organize the pages as per your unique needs it becomes a relatively easy task to. 

2. What is Promethease?

Promethease allows users to analyze their genetic data and compare personal genomics results against the SNPedia database. SNPedia is a wiki-styled genetic data repository. 

Though popular, it is often criticized for being too technical and difficult to read. You can take a look at Promethease's sample report here.

Promethease is a do-it-yourself (DIY) tool for health genetic information from 23andMe raw data. It is a third party online tool that provides consumers information about their genetic variants and how they affect your health. After 23andme FDA ban on providing health reports, people started using tools like Promethease to get more information from their DNA raw data, other than just locating distant cousins. Though Promethease is a good tool built on a repository like SNPedia there are a number of factors to consider before you decide to upload your raw data to Promethease. Promethease is popular as a low-cost offering, but it’s also very technical and disease-centric. There are many alternatives to Promethease to analyze your 23andme raw data, that are easy to follow and understand. Below we present a feature by feature comparison between Promethease and Xcode Life Sciences.

3. How did Promethease gain popularity?

Promethease was one of the early companies to offer DNA raw data analysis based on 23andMe, Ancestry DNA raw data. 

What is DNA Raw Data?

A DNA raw data is a file that contains information about your genetic variants. These are called single nucleotide polymorphisms or SNPs and account for the differences in different traits like eye and hair color, height, and skin pigmentation across individuals. Your ancestry DNA raw data is a lab-generated text file. It is usually in the following two formats

• .txt file of size 14-17 MB
• zip file of size 5-7 MB

The whole-genome files have a size of 80-90 GB (30x). All the top consumer genetic testing companies like 23andMe, AncestryDNA, Family Tree DNA enable their customers to [download their raw data](https://www.xcode.life/23andme-raw-data/download-23andme-dna-raw-data-third-3rd-party-tool) directly from the website or request a download. 

The raw data from different ancestry DNA testing companies have different numbers of genetic markers depending on the microarray chip used. For example, the 23andMe raw data has around 650,000 SNPs in its v5 chip and AncestryDNA has around 700,000 SNPs. 

When the FDA (briefly) banned 23andMe from providing health reports, Promethease was the only alternative and gained popularity because of its free service and low turnaround time.

Promethease is criticized for its user-unfriendly interface based on several user reviews. Some well-known competitors for this tool are Xcode Life, Codegen, Interpretive, Nutrahacker, and GEDMatch.

Update: In 2019, MyHeritage Acquired Promethease and SNPedia.

MyHeritage offered Promethease free of charge through the end of 2019 and continues to maintain SNPedia as a free resource for academic and non-profit users. The raw data of Non-European users has been shifted to MyHeritage into new accounts created for them. However, users retain ownership of their DNA raw data file and are free to delete it from MyHeritage's server.

4. How long does it take to get my Promethease reports?

Promethease takes approximately 20 minutes to generate health report from your raw data.

5. What does Promethease provide?

Promethease offers health reports based on 23andme, Ancestry DNA, Family Tree DNA, and other ancestry raw DNA data providers for a price of $12. Once you upload your DNA raw data, you will get your report in about 20 minutes.

Earlier, the reports were offered free or at a discount. So many users tried them due to the free/low-cost aspect and the high accuracy that the vastness of their content seemed to imply. However, the reports left individuals more confused than clear. 

So if you have a Promethease report that you still cannot make heads or tails of, read on.

6. What exactly do you get to know from a Promethease report?

Promethease is a wiki-style collection of peer-curated genetic information in contrast to expert-curated reports like Xcode Life's reports. You can search genes/variants/diseases as you would on Wikipedia. The results are pages of information. This is great for people who have degrees in genetics and want to learn about all the diseases they can get.

However, if you want organized information that you can use in specific aspects of your daily life, such as Nutrition, Fitness, or Ancestry, to enhance your health and wellbeing, then you may not find the Promethease reports all that helpful. Promethease's emphasis seems to be largely on the different diseases that one can get.

7. How to read my Promethease report?

Once you transfer your DNA raw data to Promethease, you will get a lengthy report. Though it may look like a massive report on the face of it, the amount of potentially useful information in the Promethease report is quite limited. Understanding and interpreting this report is a challenge. 

Let's break it down:

The total number of entries in a typical Promethease report = Approximately 25,000

Number of entries

• With Good repute = 5817
• With Bad repute = 416
• With unknown repute =18668

The "Summary" component of the Promethease report is where the information pertaining to your genotype is given. This column, for the vast majority of the entries, has information that will not be useful to most people. It contains many terms that carry no useful information for the regular user.

The number of entries remaining after removing empty entries (no annotation) and terms such as "common in ClinVar," "common on affy axiom," "none," and "complete genomics,"," is 1482.

On further removal of more such terms (normal, common, etc.), you will be left with ~800 entries.

> So, only about 800 entries out of 25,000 (~ 3%) are potentially informative entries in the Promethease report.

8. Will getting the health test from 23andme give me better results?

A lot of people think that getting the additional health report from 23andme will help them get better results. That is not true! Whether you order the Health report or the Ancestry report from 23andme, the raw data you receive is the same!

9. How does Promethease work?

This third party DNA raw data analysis tool, is a literature retrieval system from SNPedia which is a Wikipedia style repository where people can add information. It is not a systematic risk assessment tool. For example, for Alzheimer’s disease (AD), you will not get a summary of your risk for developing AD. Instead, you will get a list of scientific literature that is available that indicates or does not indicate your risk for AD for a specific variant. For a particular disease or trait, if there are 15 articles that report on that particular DNA location, based on your SNPs 2 information sources might indicate an increased risk, 5 might be neutral, and 3 towards the lower side. Promethease does not summarise these for you. Rather it returns all these 10 articles and makes you do the interpreting yourself. This is the major reason why many individuals are alarmed and confused by their Promethease report.

10. How accurate is Promethease?

The vast majority of human traits are polygenic, meaning, several genes contribute towards that trait. Even if one carries a disease variant, they may also be carrying variants that reduce the risk of disease. Even in the case of Monogenic conditions- where one single gene leads to disease, scientist have found individuals carrying these deadly mutations but apparently healthy with no sign of disease. In a majority of the cases, the genetic risk is a small contributor towards the overall risk of that disease/condition. So, one must consider all of these things in interpreting their report. 

11. Where does Promethease get all its information?

Promethease only relies on SNPedia. Several other notable and high scientific authority tools are left out from the Promethease reports.

12. How do I filter through the Promethease report?

It is impractical to sift through the dump of information that you get (anticipate about 48,000 rows of data). The tool is equipped with different kinds of filters aimed at assisting you. Some of them are gene names, haplogroup names, diseases, drug names (referred to as “medicines”), medical conditions, names of genes and race.

13. What is magnitude in Promethease?

Magnitude is a subjective parameter that measures the interest level of the information. Here is the table partially resourced from the SNPedia website that describes what each numerical value indicates.

A-C	D-F	G-H	I-N	O-Z
3 beta-Hydroxysteroid dehydrogenase deficiency	Deafness, autosomal recessive 77	Glucose-6-phosphate dehydrogenase (G6PD) deficiency	Inclusion Body Myopathy 2	Ornithine aminotransferase deficiency
3-Phosphoglycerate Dehydrogenase Deficiency	Deficiency of acetyl-CoA acetyltransferase	Galactosylceramide beta-galactosidase deficiency	Infantile Sialic acid storage disease; Salla disease	Ornithine carbamoyltransferase deficiency
Abetalipoproteinaemia	Deficiency of alpha-mannosidase	Gaucher disease	Isovaleryl-CoA dehydrogenase deficiency	Partial adenosine deaminase deficiency
Achondrogenesis, type IB; Multiple epiphyseal dysplasia type 4; Atelosteogenesis type II; Diastrophic dysplasia	Deficiency of galactokinase	Gitelman Syndrome	Joubert Syndrome 2 / Meckel Syndrome 2	Pendred syndrome
Achromatopsia	Deficiency of guanidinoacetate methyltransferase	Glutaric acidemia type 1	Joubert syndrome 28	Peroxisomal acyl-CoA oxidase deficiency
Acute infantile liver failure due to synthesis defect of mtDNA-encoded proteins	Deficiency of hydroxymethylglutaryl-CoA lyase	Glutaric acidemia type 2A	Joubert syndrome 5	Phenylketonuria
Acyl-CoA dehydrogenase family, member 9 deficiency	Deficiency of steroid 11-beta-monooxygenase	Glutaric acidemia type 2C	Joubert syndrome 7	Phosphoribosylpyrophosphate synthetase superactivity
Adrenoleukodystrophy	Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferase	Glycine encephalopathy (AMT-related)	Junctional epidermolysis bullosa (LAMA3 related)	Polyglandular autoimmune syndrome, type 1
Adult polyglucosan body neuropathy	Dihydrolipoamide dehydrogenase deficiency	Glycine encephalopathy (GLDC-related)	Junctional epidermolysis bullosa (LAMB3 related)	Polymicrogyria
Aicardi Goutieres syndrome 5	Duchenne muscular dystrophy	Glycogen storage disease due to glucose-6-phosphatase deficiency type IA	Junctional epidermolysis bullosa (LAMC2 related)	Pontocerebellar hypoplasia type 1A
Alpha thalassemia-X-linked intellectual disability syndrome	Dyskeratosis congenita, autosomal recessive, 5	Glycogen storage disease type 1B	Juvenile retinoschisis	Pontocerebellar hypoplasia type 2D
Alport Syndrome (COL4A3-related)	Dystrophic epidermolysis bullosa	Glycogen storage disease type 2	Lamellar Ichthyosis, Type 1	Pontocerebellar hypoplasia type 6
Alport Syndrome (COL4A4-related)	Ehlers-Danlos syndrome dermatosparaxis type	Glycogen storage disease type 3	Laminin alpha 2-related dystrophy	Primary carnitine deficiency
Alport Syndrome, X-linked (COL4A5-related)	Ellis-van Creveld syndrome (EVC-related)	Glycogen storage disease type 4	Laryngo-onycho-cutaneous syndrome	Primary Ciliary Dyskinesia (DNAH11-related)
Alstrom syndrome	Ellis-van Creveld syndrome (EVC2-related)	Glycogen storage disease type 5	Leber congenital amaurosis 10	Primary Ciliary Dyskinesia (DNAH5-related)
Anauxetic dysplasia; Cartilage-hair hypoplasia; Metaphyseal dysplasia without hypotrichosis	Emery-Dreifuss muscular dystrophy, X-linked	Glycogen storage disease type 7	Leber congenital amaurosis 13	Primary Ciliary Dyskinesia (DNAI1-related)
Andermann Syndrome	Enhanced s-cone syndrome	GRACILE syndrome/ BCS1L-related disorders	Leber congenital amaurosis 2	Primary Ciliary Dyskinesia (DNAI2-related)
Arginase deficiency	Ethylmalonic encephalopathy	Hemochromatosis type 2A	Leber congenital amaurosis 5	Primary hyperoxaluria type I
Argininosuccinate lyase deficiency	Fabry disease	Hemochromatosis type 3	Leber congenital amaurosis 8	Primary hyperoxaluria type II
Aromatase deficiency	Familial dysautonomia	Hereditary acrodermatitis enteropathica	Leigh syndrome, French Canadian type	Primary hyperoxaluria type III
Arthrogryposis, mental retardation, and seizures	Familial hypercholesterolemia (LDLR related)	Hereditary factor IX deficiency disease	Lethal congenital contracture syndrome	Progressive familial intrahepatic cholestasis 2
Arts syndrome	Familial hypercholesterolemia (LDLRAP1 related)	Hereditary fructosuria	Leukoencephalopathy with vanishing white matter	Propionic acidemia (PCCA related)
Asparagine synthetase deficiency	Familial Hyperinsulinism, ABCC8-Related	Hereditary insensitivity to pain with anhidrosis	Limb-girdle muscular dystrophy type 2A	Propionic acidemia (PCCB related)
Aspartylglucosaminuria	Familial isolated deficiency of vitamin E	Hereditary spastic paraplegia 15	Limb-girdle muscular dystrophy type 2B	Pyknodysostosis
Ataxia-telangiectasia syndrome	Fanconi anemia type A	Hermansky-Pudlak syndrome type 1	Limb-girdle muscular dystrophy type 2C	Pyruvate carboxylase deficiency
Autosomal recessive osteopetrosis 1	Fanconi anemia type C	Hermansky-Pudlak syndrome type 3	Limb-girdle muscular dystrophy type 2D	Pyruvate dehydrogenase E1-alpha deficiency
Autosomal recessive polycystic kidney disease	Fanconi anemia type G	Holocarboxylase synthetase deficiency	Limb-girdle muscular dystrophy type 2E	Pyruvate dehydrogenase E1-beta deficiency
Bardet-Biedl syndrome 1	Fetal akinesia deformation sequence	Homocystinuria (CBS related)	Limb-girdle muscular dystrophy type 2F	Renal tubular acidosis with progressive nerve deafness
Bardet-Biedl syndrome 10	Finnish congenital nephrotic syndrome	Homocystinuria due to MTHFR deficiency	Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency	Retinitis pigmentosa 20
Bardet-Biedl syndrome 12	Fragile X syndrome	Homocystinuria, cobalamin E type	Lysinuric protein intolerance	Retinitis pigmentosa 25
Bardet-Biedl syndrome 13	Fukuyama congenital muscular dystrophy	Hydrolethalus syndrome	Lysosomal acid lipase deficiency	Retinitis pigmentosa 26
Bardet-Biedl syndrome 14	Fumarase deficiency	Hyperlipoproteinemia, type I	Maple syrup urine disease type 1A	Retinitis pigmentosa 28
Bardet-Biedl syndrome 2		Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome	Maple syrup urine disease type 1B	Retinitis pigmentosa 59
Bare lymphocyte syndrome 2		Hypohidrotic X-linked ectodermal dysplasia	Maple syrup urine disease type 2	Retinitis pigmentosa 73
Bartter disease type 4a		Hypophosphatasia	Meckel-Gruber syndrome	Retinitis pigmentosa 76
BH4-deficient hyperphenylalaninemia A			Meckel syndrome type 1	Rhizomelic chondrodysplasia punctata type 1/ Refsum disease (PEX7-related)
Bifunctional peroxisomal enzyme deficiency			Meckel syndrome type 4	Rhizomelic chondrodysplasia punctata type 3
Bloom syndrome			Meckel syndrome, type 5	Roberts-SC phocomelia syndrome
Canavan Disease			Medium-chain acyl-coenzyme A dehydrogenase deficiency	Sandhoff disease
Carnitine palmitoyltransferase I deficiency			Megalencephalic leukoencephalopathy with subcortical cysts 1	Schimke immuno-osseous dysplasia
Carnitine palmitoyltransferase II deficiency			Menkes kinky-hair syndrome	Segawa syndrome
Carpenter syndrome 1			Metachromatic leukodystrophy (ARSA related)	Senior-Loken syndrome 6
Cerebrotendinous xanthomatosis			Metachromatic leukodystrophy due to	Severe combined immunodeficiency (RAG2-related)
Charcot-Marie-Tooth disease type 4D			saposin-b deficiency	Severe combined immunodeficiency due to ADA deficiency
Charcot-Marie-Tooth disease, X-linked			Methylmalonic acidemia (MMAA related)	Severe combined immunodeficiency due to DCLRE1C deficiency
Charcot-Marie-Tooth Neuropathy X			Methylmalonic acidemia (MMAB related)	Severe combined immunodeficiency, X-linked
Charlevoix-Saguenay spastic ataxia			Methylmalonic Aciduria and Homocystinuria, Type cblC	Severe congenital neutropenia 3
Choreoacanthocytosis			Methylmalonic Aciduria and Homocystinuria, Type cblD	Severe congenital neutropenia 5, autosomal recessive
Choroideremia			Microcephaly, postnatal progressive, with seizures and brain atrophy	Severe X-linked myotubular myopathy
Chronic granulomatous disease (CYBA related)			Microphthalmia /clinical anophthalmia (VSX2-related)	Sjögren-Larsson syndrome
Chronic granulomatous disease, X-linked			Mitochondrial complex I deficiency/ Leigh syndrome (NDUFAF5-related)	Smith-Lemli-Opitz syndrome
Citrin deficiency			Mitochondrial complex I deficiency/ Leigh syndrome (NDUFAF6-related)	Spastic paraplegia 49, autosomal recessive
Citrullinemia type I			Mitochondrial DNA depletion syndrome 1 (MNGIE type)	Spinal muscular atrophy
Cockayne syndrome type A			MPV17-related mitochondrial DNA maintenance defect	Spondylocostal dysostosis
Cockayne syndrome type B			Mucolipidosis type II	Steel syndrome
Cohen syndrome			Mucolipidosis type III gamma	Stuve-Wiedemann Syndrome
Combined malonic and methylmalonic aciduria			Mucolipidosis type IV	Tay-Sachs disease
Combined oxidative phosphorylation deficiency 1			Mucopolysaccharidosis type I (Hurler syndrome)	Tooth agenesis, selective, 4; Odonto-onycho-dermal dysplasia; Schopf-Schulz-Passarge syndrome
Combined oxidative phosphorylation deficiency 3			Mucopolysaccharidosis type II (Hurler syndrome)	Tyrosinemia type I
Combined Pituitary Hormone Deficiency-2			Mucopolysaccharidosis type IIIA	Tyrosinemia type II
Combined Pituitary Hormone Deficiency-3			Mucopolysaccharidosis type IIIB (Sanfilippo B)	Usher syndrome type 1B
Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency			Mucopolysaccharidosis type IIIC	Usher syndrome type 1C
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency			Mucopolysaccharidosis type IIID	Usher syndrome type 1D
Congenital Adrenal Hyperplasia			Mucopolysaccharidosis type IVB (Morquio B syndrome)/ GM1 gangliosidosis	Usher syndrome type 1F
Congenital amegakaryocytic thrombocytopenia			Mucopolysaccharidosis type IX	Usher syndrome type 2A
Congenital bilateral aplasia of vas deferens from CFTR mutation			Mucopolysaccharidosis type VI	Usher syndrome type 3A
Congenital disorder of glycosylation type 1A			Multiple sulfatase deficiency	Very long-chain acyl-CoA dehydrogenase deficiency
Congenital disorder of glycosylation type 1B			Muscular dystrophy-dystroglycanopathy, FKTN-related	Walker-Warburg congenital muscular dystrophy
Congenital disorder of glycosylation type 1C			Myopathy, lactic acidosis, and sideroblastic anemia 1	Werdnig-Hoffmann disease
Congenital hyperammonemia, type I			N-acetylglutamate Synthase Deficiency	Wilson disease
Congenital Hyperinsulinism			Nemaline myopathy 2	Xeroderma pigmentosum group A
Congenital muscular dystrophy-dystroglycanopathy			Nephrogenic diabetes insipidus	Xeroderma pigmentosum, group C
Congenital myasthenic syndrome			Nephrotic syndrome, idiopathic, steroid-resistant	Zellweger spectrum disorder (PEX1-related)
Congenital myasthenic syndrome (CHRNE)			Neuronal ceroid lipofuscinosis 1	Zellweger spectrum disorder (PEX10-related)
Corneal dystrophy-perceptive deafness syndrome			Neuronal ceroid lipofuscinosis 2	Zellweger spectrum disorder (PEX12-related)
Corneal endothelial dystrophy			Neuronal ceroid lipofuscinosis 3	Zellweger spectrum disorder (PEX2-related)
Corticosterone Methyloxidase Deficiency			Neuronal ceroid lipofuscinosis 5	Zellweger spectrum disorder (PEX6-related)
Costeff Syndrome (3-Methylglutaconic Aciduria, Type 3)			Neuronal ceroid lipofuscinosis 6
Creatine transporter deficiency			Neuronal ceroid lipofuscinosis 7
Cystic fibrosis			Neuronal ceroid lipofuscinosis 8
Cystinosis			Niemann-Pick disease type C1
			Niemann-Pick disease type C2
			Niemann-Pick Disease, Types A/B
			Nijmegen breakage syndrome
			Nonsyndromic hearing loss and deafness

14. What is Promethease repute?

Good repute: The variation has a positive influence on you.

Not set: There is no verified information on the nature of the variation.

Bad repute: The variation has a negative influence on you.

According to the SNPedia website, it is better to leave the repute as “Not Set” as all genotypes have a little of both the “good” and “bad” repute.

15. What are ClinVar diseases?

This option allows you to see only the SNPs present in ClinVar. ClinVar is a freely accessible public archive of information on genetic variations specifically with clinical implications. It is maintained by the National Institute of Health (NIH). When you filter using this option you will find all the medical conditions that have been formally labeled by ClinVar.

16. How is Xcode Life different from Promethease?

How is Xcode Life Report different from the Promethease report?

Xcode Life puts together expert-curated references of variant annotations from several large databases and leading scientific journals. 

The information is then organized systematically into topical reports such as Nutrition, Health, Fitness, Skin, Allergy, Ancestry, etc. 

Each report is further organized into traits, which provide actionable insights into your genetic type along with specific recommendations. Xcode reports are easily readable, understandable, and implementable. 

The core philosophy of Xcode reports, in contrast to Promethease's voluminous coverage of diseases, is to empower the user with actionable genetic information that they can use to enhance health and wellbeing. Each report is reasonably priced at around $20; additionally, there are package discounts if the user buys multiple reports together.

If you are not looking for anything specific and just want to satisfy your curiosity, then Promethease may be the way to go. Even then, it is very likely that you will be left scratching your head with a vast load of information that you can't make sense of. But, if you want specific, organized, and actionable insights from your genetic data about your health and wellbeing, then you certainly must try the Xcode Health reports.

Drug (A-C)	Gene	Guidelines	Drug (D-N)	Gene	Guidelines	Drug (O-Z)	Gene	Guidelines
(R)-methadone;(S)-EDDP;methadone	UGT2B7	PGX	Dabigatran	CES1	PGX	o-desmethyltramadol;tramadol	RFPL4B	PGX
3,4-methylenedioxymethamphetamine	SLC6A2	PGX	daclatasvir;peginterferon alfa-2a;peginterferon alfa-2b;ribavirin	IFNL3;IFNL4	PGX	olanzapine	ABCB1	PGX
abacavir	HLA-B	CPIC	dalcetrapib	ADCY9	PGX	olanzapine	BDNF	PGX
abacavir	HLA-B	DPWG	dapsone	HLA-DRB1	PGX	olanzapine	GIPR	PGX
abacavir	HLA-B	FDA	daptomycin	ABCB1	PGX	olanzapine;perphenazine	RGS4	PGX
abacavir	LST1;LTA;LTB	PGX	darifenacin	CYP2D6	FDA	olanzapine;risperidone	DRD2	PGX
abiraterone;prednisolone	DSE;TSPYL1	PGX	dasatinib;imatinib	ABCG2	PGX	olanzapine;risperidone	HTR2A	PGX
ABT-751	UGT1A4	PGX	dasatinib;imatinib;nilotinib	ABCG2	PGX	omeprazole	CYP2C19	CPIC
acamprosate	GRIN2B	PGX	daunorubicin	NOS3	PGX	omeprazole	CYP2C19	DPWG
Ace Inhibitors;Plain	XPNPEP2	PGX	debrisoquine	CYP2D6	PGX	omeprazole	CYP2C19	FDA
Ace Inhibitors;Plain;Angiotensin II Antagonists;Beta Blocking Agents;digoxin;diuretics;spironolactone	ADRB2	PGX	deferasirox	ABCG2	PGX	omeprazole	ABCB1	PGX
Ace Inhibitors;Plain;Angiotensin II Antagonists;Beta Blocking Agents;digoxin;diuretics;spironolactone	NOS3	PGX	deferasirox	UGT1A3	PGX	ondansetron	CYP2D6	CPIC
acenocoumarol	CYP4F2	PGX	deferiprone	UGT1A6	PGX	ondansetron	ABCB1	PGX
acenocoumarol	VKORC1	PGX	deleobuvir;faldaprevir	IFNL3;IFNL4	PGX	Opioid anesthetics;Other general anesthetics;volatile anesthetics	OPRM1	PGX
acenocoumarol;phenprocoumon	VKORC1	PGX	desflurane	CACNA1S	PGX	opioids	OPRM1	PGX
acenocoumarol;warfarin	APOE	PGX	desflurane;enflurane;halothane;isoflurane;methoxyflurane;sevoflurane;succinylcholine	RYR1	PGX	Opium alkaloids and derivatives	CHRNA3	PGX
acetaldehyde	ALDH2	PGX	desipramine	CYP2D6	CPIC	Opium alkaloids and derivatives	CHRNA5	PGX
acetaldehyde	PGM1	PGX	desipramine	CYP2D6	FDA	oseltamivir	ABCB1	PGX
acetaminophen	TRPV1	PGX	desipramine	MC1R	PGX	oxaliplatin	ABCB1	PGX
acetaminophen	UGT1A	PGX	desloratadine	HRH1	PGX	oxazepam	UGT2B15	PGX
acetaminophen;aspirin;diclofenac;propionic acid derivatives;Pyrazolones	PLA2G4A	PGX	desloratadine;mizolastine	FCER1A	PGX	oxcarbazepine	HLA-B	CPIC
acetaminophen;ibuprofen;loxoprofen;salicylamide		PGX	deutetrabenazine	CYP2D6	FDA	oxcarbazepine	HLA-B	FDA
acetaminophen;tramadol	OPRM1	PGX	dexamethasone	SERPINE1	PGX	oxcarbazepine	ABCB1	PGX
acetylcholine	ACE	PGX	dexamethasone;doxorubicin;vincristine	ABCB1	PGX	oxycodone	COMT	PGX
acetylcysteine	TOLLIP	PGX	dexamethasone;lenalidomide	ABCB1	PGX	paclitaxel	ABCB1	PGX
adalimumab	ATG16L1	PGX	dexlansoprazole	CYP2C19	CPIC	paclitaxel;Platinum compounds	CASP7	PGX
adalimumab	HFE	PGX	dexlansoprazole	CYP2C19	FDA	paliperidone	MC4R	PGX
adalimumab;certolizumab pegol;etanercept;glucocorticoids;infliximab;methotrexate	KLRD1	PGX	dexmedetomidine	ADRA2A	PGX	pantoprazole	CYP2C19	CPIC
adalimumab;etanercept;infliximab	FCGR3A	PGX	dextroamphetamine;methylphenidate	DRD1	PGX	pantoprazole	CYP2C19	DPWG
adalimumab;etanercept;infliximab;Tumor necrosis factor alpha (TNF-alpha) inhibitors	TRAF1	PGX	diazepam	CYP2C19	FDA	pantoprazole	CYP2C19	FDA
adalimumab;infliximab	FCGR2A	PGX	dicloxacillin	ABCB1	PGX	pantoprazole	ABCB1	PGX
adefovir dipivoxil	SLC22A6	PGX	didanosine	NT5C2	PGX	paroxetine	CYP2D6	CPIC
adefovir dipivoxil;cidofovir;tenofovir	SLC22A6	PGX	difluorodeoxyuridine	CDA	PGX	paroxetine	CYP2D6	DPWG
adrenergics, inhalants		PGX	digoxin	ABCB1	PGX	paroxetine	CYP2D6	FDA
agomelatine	ABCB1	PGX	Dihydropyridine derivatives	NOS1AP	PGX	paroxetine	CYP1A2	PGX
alemtuzumab;chlorambucil;cyclophosphamide;fludarabine;prednisone;rituximab;vincristine	CXCL12	PGX	diltiazem	PLCD3	PGX	paroxetine	HTR1A	PGX
alendronate	VDR	PGX	dimethyl fumarate	GSTP1	PGX	pazopanib	HLA-B	FDA
alfentanil	OPRM1	PGX	Dipeptidyl peptidase 4 (DPP-4) inhibitors	CDKAL1	PGX	pazopanib	UGT1A1	FDA
Alkylating Agents	EGFR	PGX	direct acting antivirals	IFNL4	PGX	peginterferon alfa-2a	IFNL3;IFNL4	PGX
Alkylating Agents;cisplatin	ESR1	PGX	disopyramide	KCNH2	PGX	peginterferon alfa-2a;peginterferon alfa-2b	IFNL3;IFNL4	PGX
allopurinol	HLA-B	CPIC	disulfiram	SLC6A3	PGX	peginterferon alfa-2a;peginterferon alfa-2b;ribavirin	IFNL3	PGX
allopurinol	HLA-B	FDA	diuretics	PDE4D	PGX	peginterferon alfa-2a;peginterferon alfa-2b;ribavirin	IFNL3;IFNL4	PGX
allopurinol	ABCG2	PGX	diuretics;hydrochlorothiazide	NEDD4L	PGX	peginterferon alfa-2a;peginterferon alfa-2b;ribavirin	IFNL4	PGX
allopurinol	CYCSP5	PGX	dobutamine	ADRB1	PGX	peginterferon alfa-2a;peginterferon alfa-2b;ribavirin;simeprevir	IFNL4	PGX
allopurinol;febuxostat	AOX1	PGX	docetaxel	CYP3A4	PGX	peginterferon alfa-2a;peginterferon alfa-2b;ribavirin;telaprevir	IFNL3	PGX
allopurinol;febuxostat	UGT1A1;UGT1A10;UGT1A3;UGT1A4;UGT1A5;UGT1A6;UGT1A7;UGT1A8;UGT1A9	PGX	docetaxel	SLCO1B3	PGX	peginterferon alfa-2a;peginterferon alfa-2b;ribavirin;telaprevir	IFNL3;IFNL4	PGX
alprazolam	CYP3A;CYP3A4	PGX	docetaxel	VEGFA	PGX	peginterferon alfa-2a;ribavirin	SCARB1	PGX
amantadine;Anticholinergics;Dopamine agonists;levodopa;selegiline	SLC22A1	PGX	docetaxel;doxorubicin	AKR1C3	PGX	peginterferon alfa-2a;ribavirin	VDR	PGX
amifampridine	NAT2	FDA	docetaxel;epirubicin	MDM4	PGX	peginterferon alfa-2b	HLA-DPA1	PGX
amifampridine phosphate	NAT2	FDA	docetaxel;FEC100;gemcitabine;trastuzumab;zoledronate	PPCDC	PGX	peginterferon alfa-2b;protease inhibitors;ribavirin	SLC28A2	PGX
amiloride;spironolactone	CYP4A11	PGX	docetaxel;gemcitabine;paclitaxel;Platinum compounds;vinorelbine	CASP7	PGX	peginterferon alfa-2b;ribavirin	ITPA	PGX
aminoglycoside antibacterials	MT-RNR1	PGX	docetaxel;thalidomide	CHST3	PGX	pemetrexed	GGH	PGX
amiodarone	NOS1AP	PGX	dolasetron;granisetron	NOS1AP	PGX	pemetrexed	MTHFR	PGX
amiodarone;Antibiotics;antipsychotics;diuretics;quinidine;sotalol	KCNE1	PGX	dolutegravir	UGT1A1	FDA	perindopril	BDKRB1	PGX
amisulpride	MC4R	PGX	dolutegravir	ABCG2	PGX	perphenazine	CYP2D6	FDA
amisulpride;antipsychotics;olanzapine;quetiapine;risperidone	HTR1A	PGX	donepezil	CYP2D6	FDA	Pertussis vaccines	TLR4	PGX
amisulpride;aripiprazole;clozapine;lithium;mirtazapine;olanzapine;paliperidone;quetiapine;risperidone;valproic acid	SH2B1	PGX	donepezil	BCHE	PGX	phenazepam	CYP2C19	PGX
amitriptyline	CYP2C19	CPIC	donepezil	CHAT	PGX	phenobarbital	ABCB1	PGX
amitriptyline	CYP2D6	CPIC	donepezil;galantamine;rivastigmine	CHAT	PGX	phenobarbital;phenytoin	MTHFR	PGX
amitriptyline	CYP2D6	DPWG	donepezil;galantamine;rivastigmine	CHRNA7	PGX	phenprocoumon	VKORC1	PGX
amitriptyline	CYP2D6	FDA	doxepin	CYP2C19	CPIC	phenytoin	CYP2C9	DPWG
amitriptyline;antidepressants;citalopram;fluvoxamine;paroxetine;sertraline;venlafaxine	ABCB1	PGX	doxepin	CYP2C19	FDA	phenytoin	CFHR4	PGX
amitriptyline;antidepressants;citalopram;paroxetine;venlafaxine	ABCB1	PGX	doxepin	CYP2D6	CPIC	phenytoin	SCN1A	PGX
amitriptyline;citalopram;fluoxetine;paroxetine;sertraline;venlafaxine	ABCB1	PGX	doxepin	CYP2D6	DPWG	photodynamic therapy	F13A1	PGX
amitriptyline;citalopram;paroxetine;venlafaxine	ABCB1	PGX	doxepin	CYP2D6	FDA	pimozide	CYP2D6	DPWG
amlodipine	CYP3A4	PGX	doxorubicin	ABCC1	PGX	pimozide	CYP2D6	FDA
amlodipine;chlorthalidone	NPPA	PGX	doxorubicin	CBR3	PGX	pioglitazone	ADIPOQ	PGX
amlodipine;chlorthalidone;lisinopril	ACE	PGX	doxorubicin;doxorubicinol	CBR1	PGX	piroxicam	CYP2C9	CPIC
amlodipine;chlorthalidone;lisinopril	AGT	PGX	doxorubicin;idarubicin	CYBA	PGX	piroxicam	CYP2C9	FDA
amodiaquine	CYP2C8	PGX	doxorubicin;methotrexate;prednisolone;vincristine	ABCB1	PGX	pitavastatin	ABCC2	PGX
amodiaquine;pyrimethamine;sulfadoxine	G6PD	PGX	dronabinol	CYP2C9	FDA	pitrakinra	IL4R	PGX
amoxapine	CYP2D6	FDA	Drug(s)	Gene	PGX	platinum	ERCC5	PGX
amoxicillin;clavulanate	HLA-DQB1	PGX	Drugs For Treatment Of Tuberculosis	NAT2	PGX	Platinum compounds	GSTP1	PGX
amphetamine	CYP2D6	FDA	Drugs For Treatment Of Tuberculosis;isoniazid	ABCB1	PGX	Platinum compounds	HSPA5	PGX
amphetamine	DRD2	PGX	Drugs For Treatment Of Tuberculosis;rifampin	RIPOR2	PGX	Platinum compounds	XRCC1	PGX
amphetamine;cannabinoids;cocaine;opioids	KAT2B	PGX	Drugs used in alcohol dependence	GATA4	PGX	Platinum compounds;radiotherapy		PGX
amprenavir	SLCO1B1	PGX	Drugs Used In Diabetes	IRS1	PGX	Platinum compounds;taxanes	ABCB1	PGX
Analgesics	KCNJ6	PGX	Drugs used in nicotine dependence;nicotine	CHRNA3	PGX	pramipexole	DRD3	PGX
Analgesics;Antiinflammatory agents, non-steroids;Ergot alkaloids;opioids;sumatriptan	COMT	PGX	Drugs used in nicotine dependence;nicotine;varenicline	CHRNA5	PGX	prasugrel	CYP2C19	PGX
Analgesics;Antiinflammatory agents, non-steroids;Ergot alkaloids;opioids;sumatriptan	OPRM1	PGX	duloxetine	NCAM1	PGX	pravastatin	KIF6	PGX
anastrozole	CYP19A1	PGX	duloxetine	ZNF385D	PGX	pravastatin	SLCO1B1	PGX
anastrozole;exemestane	MAP4K4	PGX	eculizumab	C5	PGX	pravastatin;simvastatin	HMGCR	PGX
anastrozole;exemestane;letrozole	CYP19A1	PGX	eculizumab	CR1	PGX	prednisone;tacrolimus	ABCB1	PGX
anastrozole;letrozole	TNFRSF11B	PGX	efavirenz	CYP2B6	CPIC	pregabalin	SLC7A5	PGX
anastrozole;letrozole	TNFSF11	PGX	efavirenz	CYP2B6	DPWG	prochlorperazine	ANKK1;DRD2	PGX
angiotensin II	AGTR1	PGX	efavirenz	CYP2B6	FDA	propafenone	CYP2D6	DPWG
anthracyclines and related substances	CBR3	PGX	efavirenz	CYP2B6	PGX	propafenone	CYP2D6	FDA
anthracyclines and related substances	HAS3	PGX	efavirenz;lopinavir;Nucleoside and nucleotide reverse transcriptase inhibitors;ritonavir		PGX	propofol	CYP2B6	PGX
anthracyclines and related substances;cyclophosphamide;doxorubicin;epirubicin;fluorouracil;methotrexate;oxaliplatin;Platinum compounds	NOS3	PGX	efavirenz;nelfinavir	ABCB1	PGX	propofol;remifentanil	ABCB1	PGX
anthracyclines and related substances;taxanes	ABCB1	PGX	egfr inhibitors	EGFR	PGX	propranolol	CYP2D6	FDA
Antibiotics	LGALS3	PGX	elagolix	SLCO1B1	FDA	propranolol	ADRB2	PGX
antidepressants	HTR2A	PGX	eliglustat	CYP2D6	DPWG	protriptyline	CYP2D6	FDA
antidepressants	SLC6A4	PGX	eliglustat	CYP2D6	FDA	quetiapine	COMT	PGX
antidepressants;antiepileptics;Beta Blocking Agents;calcium channel blockers	ACE	PGX	enalapril		PGX	quetiapine	MC4R	PGX
antidepressants;antipsychotics;benzodiazepine derivatives;opioids;Sympathomimetics	OPRM1	PGX	enalapril	ACE	PGX	quinapril	AGT	PGX
antidepressants;benzodiazepine derivatives;mirtazapine;Selective serotonin reuptake inhibitors	GAL	PGX	enalapril;imidapril;lisinopril	BDKRB2	PGX	rabeprazole	CYP2C19	FDA
antidepressants;citalopram	CREB1;METTL21A	PGX	endoxifen		PGX	radiotherapy	CDK1	PGX
antidepressants;citalopram;clomipramine;lithium;nefazodone;paroxetine;venlafaxine	FKBP5	PGX	enflurane	CACNA1S	PGX	raloxifene	UGT1A8	PGX
antidepressants;citalopram;escitalopram;fluoxetine;paroxetine	TPH1	PGX	entacapone	COMT	PGX	raltegravir	UGT1A1	FDA
antidepressants;citalopram;fluoxetine	SERPINE1	PGX	Enzymes	A2M	PGX	ramipril	ACE	PGX
antidepressants;citalopram;fluvoxamine;paroxetine;sertraline;venlafaxine	ABCB1	PGX	ephedrine;phenylephrine	ADRB2	PGX	ranibizumab	NRP1	PGX
antidepressants;citalopram;paroxetine	BDNF	PGX	epirubicin;fluorouracil;oxaliplatin	NQO1	PGX	rasagiline	DRD2	PGX
antidepressants;desipramine;fluoxetine	BDNF	PGX	erdafitinib	CYP2C9	FDA	regadenoson	AMPD1	PGX
antidepressants;fluvoxamine;paroxetine;Selective serotonin reuptake inhibitors;sertraline	HTR1A	PGX	erlotinib	EGFR	PGX	remifentanil	COMT	PGX
antidepressants;mirtazapine;venlafaxine	TPH2	PGX	erythromycin	ABCC2	PGX	remifentanil;sevoflurane	ABCB1	PGX
antidepressants;Selective serotonin reuptake inhibitors	FKBP5	PGX	escitalopram	CYP2C19	CPIC	repaglinide	CYP2C8	PGX
antidepressants;Selective serotonin reuptake inhibitors;venlafaxine	GRIA3	PGX	escitalopram	CYP2C19	DPWG	repaglinide	NEUROD1	PGX
antiepileptics	ABCB1	PGX	escitalopram	CYP2C19	FDA	rhodamine 123	ABCB1	PGX
antiepileptics;carbamazepine	ABCB1	PGX	escitalopram	BMP5	PGX	rifampin	NR1I2	PGX
antiepileptics;carbamazepine;lamotrigine;oxcarbazepine;phenytoin;topiramate	SCN2A	PGX	escitalopram	CYP1A2	PGX	risperidone	CYP2D6	DPWG
antiepileptics;carbamazepine;oxcarbazepine	ABCC2	PGX	escitalopram;nortriptyline	BDNF	PGX	risperidone	CYP2D6	FDA
antiepileptics;carbamazepine;phenobarbital;phenytoin;valproic acid	SCN2A	PGX	esomeprazole	CYP2C19	FDA	risperidone	HTR2C	PGX
Antihypertensives	ATP2B1	PGX	esomeprazole	STAT6	PGX	risperidone	MC4R	PGX
Antihypertensives And Diuretics In Combination	NOS3	PGX	estradiol		PGX	ritodrine	CACNA1C	PGX
Antihypertensives;Antihypertensives And Diuretics In Combination;diuretics	NOS3	PGX	etanercept	TNF	PGX	ritonavir	APOC3	PGX
Antihypertensives;Beta Blocking Agents	GRK5	PGX	ethambutol;isoniazid;pyrazinamide;rifampin	CYP2C9	PGX	rituximab	FCGR3A	PGX
Antiinflammatory agents, non-steroids	CDKN2B-AS1	PGX	ethanol	ADH1B	PGX	rivastigmine	BCHE	PGX
Antiinflammatory agents, non-steroids	PTGS1	PGX	ethanol	OPRM1	PGX	rocuronium	ABCB1	PGX
Antiinflammatory agents, non-steroids;aspirin		PGX	etoposide	ABCB1	PGX	rofecoxib	PTGS2	PGX
Antiinflammatory agents, non-steroids;celecoxib;diclofenac	CYP2C9	PGX	etoposide	SLIT1	PGX	rosiglitazone	PAX4	PGX
antineoplastic agents	SERPINA3	PGX	etravirine	CYP2C19	PGX	rosuvastatin	SLCO1B1	FDA
antineoplastic agents	TP53	PGX	everolimus	PIK3R1	PGX	rosuvastatin	ABCG2	PGX
antipsychotics	BDNF	PGX	everolimus	RPTOR	PGX	rosuvastatin	SLCO1B1	PGX
antipsychotics	GRM3	PGX	exemestane	CYP19A1	PGX	salbutamol	ADRB2	PGX
antipsychotics;aripiprazole;bromperidol;chlorpromazine;clozapine;nemonapride;olanzapine;risperidone	DRD2	PGX	exemestane;letrozole	CYP19A1	PGX	salbutamol;selective beta-2-adrenoreceptor agonists	CRHR2	PGX
antipsychotics;aripiprazole;risperidone	ANKK1	PGX	exemestane;letrozole	ESR1	PGX	salmeterol	ADRB2	PGX
antipsychotics;chlorpromazine;fluphenazine;thioridazine;trifluoperazine	CYP1A2	PGX	Farglitazar;glibenclamide	SCNN1B	PGX	salvianolic acid b	NOS3	PGX
antipsychotics;clozapine;olanzapine	DRD2	PGX	fenofibrate	APOA5	PGX	selective beta-2-adrenoreceptor agonists	ARG1	PGX
antipsychotics;olanzapine;perphenazine;quetiapine;ziprasidone	RGS4	PGX	fenofibrate	CRP	PGX	Selective serotonin reuptake inhibitors	HTR7	PGX
antipsychotics;risperidone	LEP	PGX	fentanyl	ABCB1	PGX	sertraline	CYP2C19	CPIC
antithymocyte globulin	FCGR3A	PGX	fentanyl	OPRM1	PGX	sertraline	CYP2C19	DPWG
Antithyroid Preparations	HLA-B	PGX	fentanyl;morphine;opioids;oxycodone	RHBDF2	PGX	sertraline	GNB3;P3H3	PGX
Antivirals for treatment of HIV infections, combinations;Drugs For Treatment Of Tuberculosis	ABCB1	PGX	fentanyl;propofol;remifentanil;sevoflurane	ADRB2	PGX	sevoflurane	CACNA1S	PGX
Antivirals for treatment of HIV infections, combinations;ritonavir	APOE	PGX	fesoterodine	CYP2D6	FDA	sibutramine	GNB3	PGX
apixaban	ABCG2	PGX	fexofenadine	ABCB1	PGX	sildenafil	GNB3	PGX
aripiprazole	CYP2D6	DPWG	fexofenadine	SLCO2B1	PGX	silibinin	ABCB1	PGX
aripiprazole	CYP2D6	FDA	flecainide	CYP2D6	DPWG	simvastatin	SLCO1B1	FDA
aripiprazole	DRD2	PGX	flecainide	SCN4A	PGX	simvastatin	HMGCR	PGX
aripiprazole lauroxil	CYP2D6	FDA	flecainide;mexiletine	SCN4A	PGX	simvastatin	SLCO1B1	PGX
aripiprazole;clozapine;haloperidol;olanzapine;quetiapine;risperidone	FAAH	PGX	flecanide	CYP2D6	DPWG	simvastatin acid	SLCO1B1	PGX
aripiprazole;risperidone	DRD2	PGX	flibanserin	CYP2C19	FDA	siponimod	CYP2C9	FDA
artesunate;chlorproguanil;dapsone	G6PD	PGX	flucloxacillin	NR1I2	PGX	sirolimus	ABCB1	PGX
artesunate;primaquine;pyrimethamine;sulfadoxine	G6PD;IKBKG	PGX	fluindione	VKORC1	PGX	sirolimus;temsirolimus	NR1I2	PGX
asparaginase	NFATC2	PGX	flunisolide	TBXT	PGX	sitagliptin;vildagliptin	GLP1R	PGX
asparaginase;cyclophosphamide;cytarabine;daunorubicin;dexamethasone;doxorubicin;leucovorin;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine	GATA3	PGX	fluorouracil	DPYD	CPIC	SN-38	UGT1A9	PGX
asparaginase;cyclophosphamide;daunorubicin;prednisolone;vincristine	PNPLA3	PGX	fluorouracil	DPYD	DPWG	sofosbuvir	IFNL3;IFNL4	PGX
asparaginase;dexamethasone;methotrexate	PYGL	PGX	fluorouracil	DPYD	FDA	sofosbuvir;velpatasvir;voxilaprevir	IFNL3;IFNL4	PGX
aspirin	PPARG	PGX	fluorouracil	DPYD	PGX	somatropin recombinant	COL1A1	PGX
aspirin;Beta Blocking Agents;clopidogrel;hmg coa reductase inhibitors	NOS3	PGX	fluorouracil;FOLFIRI;FOLFOX	TYMS	PGX	sorafenib	KDR	PGX
aspirin;clopidogrel	ITGA2	PGX	fluorouracil;FOLFOX	TYMS	PGX	spironolactone	ACE	PGX
aspirin;clopidogrel;prasugrel	PEAR1	PGX	fluorouracil;irinotecan;leucovorin	ABCG1	PGX	stavudine	SAMHD1	PGX
aspirin;prasugrel	NTRK1;PEAR1	PGX	fluorouracil;irinotecan;leucovorin	ABCG2	PGX	succinylcholine	CACNA1S	PGX
ataluren	CFTR	PGX	fluorouracil;leucovorin;oxaliplatin	MTHFR	PGX	succinylcholine	BCHE	FDA
atazanavir	UGT1A1	CPIC	fluorouracil;oxaliplatin	PARD3B	PGX	succinylcholine;volatile anesthetics	RYR1	PGX
atazanavir	UGT1A2	CPIC	fluorouracil;Platinum compounds;radiotherapy	TMEM167A;XRCC4	PGX	sufentanil	COMT	PGX
atazanavir	UGT1A3	CPIC	fluorouracil;Platinum compounds;radiotherapy	XRCC4	PGX	sufentanil	OPRM1	PGX
atazanavir	NR1I2	PGX	fluoxetine	SLC6A4	PGX	sulfamethoxazole	GCLC	PGX
atazanavir	UGT1A1	PGX	fluoxetine;sertraline	ACE	PGX	sulfasalazine	ABCG2	PGX
atazanavir;lopinavir;ritonavir;tenofovir	ABCC2	PGX	flurbiprofen	CYP2C9	FDA	sulfinpyrazone	UGT1A9	PGX
atazanavir;ritonavir	UGT1A7	PGX	flurbiprofen	CYP2C9	PGX	sulfonamides, urea derivatives	TCF7L2	PGX
atenolol	DPYS	PGX	fluticasone propionate;montelukast	CA10	PGX	sulindac	FMO3	PGX
atenolol	GNB3	PGX	fluvastatin	ACE	PGX	sumatriptan	GNB3	PGX
atenolol;bisoprolol		PGX	fluvastatin	CETP	PGX	sunitinib	ABCB1	PGX
atenolol;hydrochlorothiazide	ALDH1A2	PGX	fluvastatin	SLCO1B1	PGX	sunitinib	FLT3	PGX
atenolol;hydrochlorothiazide;metoprolol	SLC25A31	PGX	fluvastatin;simvastatin	LIPC	PGX	tacrolimus	CYP3A5	CPIC
atenolol;irbesartan	EDN1	PGX	fluvoxamine	CYP2B6	CPIC	tacrolimus	CYP3A5	FDA
atenolol;metoprolol	ADRB2	PGX	fluvoxamine	COMT	PGX	tacrolimus	CYP3A4	PGX
atenolol;verapamil	CACNA1C	PGX	fluvoxamine	FGF2	PGX	talinolol	ABCB1	PGX
atomoxetine	CYP2D6	CPIC	fluvoxamine	HTR2A	PGX	tamoxifen	CYP2D6	CPIC
atomoxetine	CYP2D6	DPWG	fluvoxamine	CYP2D6	FDA	tamoxifen	CYP2D6	DPWG
atomoxetine	CYP2D6	FDA	fluvoxamine;milnacipran;paroxetine	HTR1A	PGX	tamoxifen	CYP2D6	FDA
atomoxetine	SLC6A2	PGX	fluvoxamine;paroxetine	HTR2A	PGX	tamoxifen	CYP19A1	PGX
atorvastatin	APOE	PGX	folic acid	MTHFR	PGX	tamoxifen	UGT1A4	PGX
atorvastatin	SLCO1B1	PGX	folic acid;methotrexate	TLR4	PGX	tamsulosin	CYP2D6	FDA
atorvastatin;Bisphosphonates	FDPS	PGX	folic acid;vitamin b-complex, plain	MTHFR	PGX	taxanes		PGX
atorvastatin;fluvastatin;hmg coa reductase inhibitors;lovastatin;pravastatin;simvastatin	HMGCR	PGX	folic acid;vitamin b-complex, plain	MTRR	PGX	tegafur	DPYD	DPWG
atorvastatin;hmg coa reductase inhibitors;pravastatin;simvastatin	HTR7	PGX	follitropin beta;thyrotropin alfa;urofollitropin	FSHR	PGX	tegafur	DPYD	PGX
atorvastatin;hmg coa reductase inhibitors;rosuvastatin	COQ2	PGX	forskolin	ABCB1	PGX	telaprevir	CYP24A1	PGX
atorvastatin;lovastatin;simvastatin	APOA5	PGX	furosemide	ABCC4	PGX	telmisartan	GNB3	PGX
atorvastatin;pravastatin;simvastatin	ABCA1	PGX	furosemide;spironolactone	ADD1	PGX	telmisartan	SLCO1B3	PGX
atorvastatin;quinapril	ACE	PGX	gabapentin	SLC7A5	PGX	temozolomide	ABCB1	PGX
atorvastatin;rifampin	SLCO1B1	PGX	galantamine	CYP2D6	FDA	tenofovir	ABCC4	PGX
atorvastatin;simvastatin	PON1	PGX	galantamine	CHAT	PGX	tenofovir disoproxil fumarate	CYP27B1	PGX
atorvastatin;simvastatin	RYR2	PGX	gefitinib	CYP2D6	FDA	tenoxicam	CYP2C9	CPIC
avatrombopag	CYP2C9	FDA	gefitinib	ABCB1	PGX	terbutaline	ADRB2	PGX
axitinib;sorafenib	HIF1A	PGX	gefitinib	EGFR	PGX	tetrabenazine	CYP2D6	FDA
azathioprine	NUDT15	CPIC	geldanamycin	EGFR	PGX	thalidomide	ERCC1	PGX
azathioprine	NUDT15	DPWG	gemcitabine	NT5C2	PGX	Thiazides, plain	GNB3	PGX
azathioprine	TPMT	CPIC	gemcitabine	RRM1	PGX	thiazolidinediones	AQP2	PGX
azathioprine	TPMT	DPWG	gemcitabine;paclitaxel	CDA	PGX	thioguanine	NUDT15	CPIC
azathioprine	TPMT	FDA	gemcitabine;paclitaxel	SLC29A1	PGX	thioguanine	TPMT	CPIC
azathioprine	FTO	PGX	gemcitabine;Platinum compounds	CASP7	PGX	thioguanine	TPMT	DPWG
azathioprine	NUDT15	PGX	gemcitabine;Platinum compounds	RRM1	PGX	thioguanine	TPMT	FDA
azathioprine;mercaptopurine		PGX	gemtuzumab ozogamicin	CD33	PGX	thioridazine	CYP2D6	FDA
azathioprine;mercaptopurine;thioguanine	NUDT15	PGX	glatiramer acetate		PGX	thioridazine	CYP2D6	PGX
azathioprine;purine analogues	ITPA	PGX	glibenclamide	NOS1AP	PGX	thiotepa	GSTP1	PGX
belinostat	UGT1A1	FDA	gliclazide	KCNJ11	PGX	tianeptine	OPRM1	PGX
benazepril	MTHFR	PGX	glimepiride	NOS1AP	PGX	ticagrelor	PEAR1	PGX
benazepril;imidapril	AGT	PGX	glipizide	NOS1AP	PGX	timolol		PGX
benazepril;perindopril	ACE	PGX	glucocorticoids	HSD3B1	PGX	tiotropium	ADRB2	PGX
Beta Blocking Agents	ADRB1	PGX	granisetron	ABCB1	PGX	tipifarnib	ABCB1	PGX
Beta Blocking Agents	GRK5	PGX	granisetron;palonosetron	ERCC1	PGX	tipiracil hydrochloride;trifluridine	SLC29A1	PGX
Beta blocking agents, selective	BST1	PGX	haloperidol	CYP2D6	DPWG	tocilizumab	IL6R	PGX
bevacizumab	ARMS2	PGX	haloperidol	MC4R	PGX	tolbutamide	CYP2C9	PGX
bevacizumab	CFH	PGX	haloperidol	SLC6A5	PGX	tolterodine	CYP2D6	FDA
bevacizumab	CXCR4	PGX	halothane	CACNA1S	PGX	topiramate	GRIK1	PGX
bevacizumab	EDN1	PGX	hdl cholesterol;letrozole;triglycerides	CYP19A1	PGX	topotecan	ABCG2	PGX
bevacizumab;capecitabine;cetuximab;oxaliplatin	MGAT4A	PGX	Hepatitis vaccines	IL4R	PGX	tramadol	CYP2D6	DPWG
bevacizumab;capecitabine;fluorouracil;irinotecan;leucovorin;oxaliplatin	VEGFA	PGX	heroin	OPRM1	PGX	tramadol	CYP2D6	FDA
bevacizumab;capecitabine;oxaliplatin	MGAT4A	PGX	heroin	SOD2	PGX	tramadol	OPRM1	PGX
bevacizumab;carboplatin;cisplatin;cyanocobalamin;folic acid;pemetrexed	MTHFR	PGX	heroin;methamphetamine	BDNF	PGX	trandolapril;verapamil	PTPRD	PGX
bevacizumab;fluorouracil;irinotecan;leucovorin	SHMT1	PGX	heroin;opioids	OPRM1	PGX	trastuzumab	ERBB2	PGX
bevacizumab;pegaptanib;ranibizumab	VEGFA	PGX	highly active antiretroviral therapy (haart)	OPRM1	PGX	trastuzumab	FCGR2A	PGX
bevacizumab;pemetrexed	GGH	PGX	hmg coa reductase inhibitors	LPA	PGX	triamcinolone	HCG22	PGX
bevacizumab;ranibizumab	VEGFA	PGX	hmg coa reductase inhibitors	SLCO1B1	PGX	trimipramine	CYP2C19	CPIC
bilirubin	UGT1A	PGX	hmg coa reductase inhibitors;letrozole	CYP19A1	PGX	trimipramine	CYP2D6	CPIC
bisantrene	ABCB1	PGX	hmg coa reductase inhibitors;simvastatin	GATM	PGX	trimipramine	CYP2D6	FDA
bisoprolol	ACY3	PGX	hormonal contraceptives for systemic use	F5	PGX	troglitazone		PGX
Bisphosphonates	ABCC4	PGX	Hydralazine-isosorbide dinitrate	GNB3	PGX	tropisetron	CYP2D6	CPIC
Bisphosphonates	FDPS	PGX	hydrochlorothiazide	ADD1	PGX	Tumor necrosis factor alpha (TNF-alpha) inhibitors	IL23R	PGX
Bisphosphonates;clodronate;etidronic acid;risedronate;tiludronate	IL1B	PGX	hydrochlorothiazide	KCNJ1	PGX	Tumor necrosis factor alpha (TNF-alpha) inhibitors	TNF	PGX
Bisphosphonates;pamidronate;zoledronate	CYP2C8	PGX	hydrocodone	OPRM1	PGX	Tumor necrosis factor alpha (TNF-alpha) inhibitors;ustekinumab	IL1B	PGX
bleomycin;cisplatin;etoposide	BLMH	PGX	hydroxyurea	MAP3K5	PGX	ustekinumab	TIRAP	PGX
bleomycin;cisplatin;etoposide	GSTP1	PGX	ibuprofen	PTGS2	PGX	valbenazine	CYP2D6	FDA
bleomycin;cyclophosphamide;doxorubicin;prednisone;rituximab;vincristine;vindesine	ABCB1	PGX	idarubicin	NCF4	PGX	valganciclovir	ABCB1	PGX
boceprevir;peginterferon alfa-2a;peginterferon alfa-2b;ribavirin	IFNL3;IFNL4	PGX	idarubicin	RAC2	PGX	valproic acid	POLG	PGX
bortezomib;dexamethasone;melphalan;prednisone	CTLA4	PGX	iloperidone	CYP2D6	FDA	valproic acid	UGT1A6	PGX
botulinum toxin type a	TRPV1	PGX	iloperidone	CYP2D6	PGX	vancomycin		PGX
brexpiprazole	CYP2D6	DPWG	imatinib	CYP2B6	PGX	vardenafil	CYP3A5	PGX
brexpiprazole	CYP2D6	FDA	imatinib	EGFR	PGX	varenicline	CHRNA4	PGX
brivaracetam	CYP2C19	FDA	imatinib	SLC22A1	PGX	venlafaxine	CYP2D6	DPWG
bucindolol	ADRB1	PGX	imatinib	SLC22A4	PGX	venlafaxine	CYP2D6	FDA
budesonide		PGX	imipramine	CYP2C19	CPIC	venlafaxine	HTR2A	PGX
budesonide;flunisolide;fluticasone propionate;glucocorticoids;nedocromil;triamcinolone	GLCCI1	PGX	imipramine	CYP2C19	DPWG	verapamil	KCNIP1;KCNMB1	PGX
bufuralol;dextromethorphan	CYP2D6	PGX	imipramine	CYP2D6	CPIC	vincristine	ABCB1	PGX
bumetanide;furosemide;torasemide	SLC12A3	PGX	imipramine	CYP2D6	DPWG	vincristine	CEP72	PGX
buprenorphine	COMT	PGX	imipramine	CYP2D6	FDA	vitamin e	CYP4F2	PGX
buprenorphine	OPRD1	PGX	imiquimod	TLR7	PGX	Vitamin K	CYP4F2	PGX
buprenorphine;fentanyl;meperidine;morphine;opioids;pentazocine		PGX	indinavir	CYP3A4	PGX	voriconazole	CYP2C19	CPIC
buprenorphine;fentanyl;tramadol	COMT	PGX	indinavir	UGT1A1	PGX	voriconazole	CYP2C19	DPWG
bupropion	GALR1	PGX	infliximab	TNF	PGX	voriconazole	CYP2C19	FDA
bupropion;Drugs used in nicotine dependence;nicotine;varenicline	CHRNA5	PGX	infliximab;Tumor necrosis factor alpha (TNF-alpha) inhibitors	TNFRSF1B	PGX	voriconazole	CYP3A4	PGX
bupropion;nicotine	DRD1	PGX	insulin recombinant;zinc acetate	SLC30A8	PGX	vortioxetine	CYP2D6	FDA
bupropion;nicotine;varenicline	CHRNA5	PGX	interferon alfa-2a, recombinant;interferon alfa-2b, recombinant;ribavirin	FTO	PGX	warfarin	CYP2C9	DPWG
busulfan	CYP2C9	PGX	interferon alfa-2a, recombinant;peginterferon alfa-2b	IDO1	PGX	warfarin	CYP2C9	FDA
busulfan;cyclophosphamide	CTH	PGX	interferon alfa-2b, recombinant;ribavirin	ITPA	PGX	warfarin	CYP4F2	FDA
butorphanol	COMT	PGX	interferon beta-1a	RORA	PGX	warfarin	VKORC1	FDA
caffeine	ADORA2A	PGX	interferon beta-1a;interferon beta-1b	HLA-DQA1	PGX	warfarin		PGX
caffeine	CYP1A2	PGX	interferon beta-1a;interferon beta-1b	IRF6	PGX	warfarin	CYP4F2	PGX
calcein	ABCB1	PGX	interferons	IFNL3;IFNL4	PGX	warfarin	VKORC1	PGX
calcein;lopinavir	ABCC2	PGX	interferons	STAT3	PGX	XK469	AOX1	PGX
calcium	VDR	PGX	interferons;peginterferon alfa-2a;peginterferon alfa-2b;ribavirin	IFNL3	PGX	zileuton	PRORP	PGX
calcium channel blockers	CACNA1C	PGX	interferons;ribavirin	IL18	PGX	zoledronate	FDPS	PGX
calcium channel blockers;nitrendipine	KCNH2	PGX	irbesartan	CYP2C9	PGX	zuclopenthixol	CYP2D6	DPWG
candesartan	AGTR1	PGX	irinotecan	UGT1A1	DPWG
cangrelor	P2RY12	PGX	irinotecan	UGT1A1	FDA
cannabinoids	FAAH	PGX	irinotecan	UGT1A1	PGX
cannabinoids;cocaine;ethanol;nicotine;opioids	OPRM1	PGX	irinotecan;raltitrexed	TYMS	PGX
capecitabine	DPYD	CPIC	isoflurane	CACNA1S	PGX
capecitabine	DPYD	FDA	isoniazid	BACH1	PGX
capecitabine	DPYD	PGX	isoniazid;phenytoin	NAT2	PGX
capecitabine	TYMS	PGX	isoniazid;pyrazinamide;rifampin	NAT2	PGX
capecitabine;docetaxel	CYP1A1	PGX	isoniazid;rifampin	GSTP1	PGX
capecitabine;epirubicin;platinum	GSTP1	PGX	isoproterenol	ADRB2	PGX
capecitabine;fluorouracil	HLA-G	PGX	ivacaftor	CFTR	PGX
capecitabine;fluorouracil;leucovorin;oxaliplatin	MTHFR	PGX	ivacaftor-lumacaftor	CFTR	PGX
capecitabine;fluorouracil;tegafur	TYMS	PGX	ivacaftor-tezacaftor	CFTR	PGX
capecitabine;oxaliplatin	PTGS2	PGX	ketorolac		PGX
capecitabine;radiotherapy	AREG	PGX	l-methylfolate;Vitamin B-complex, Incl. Combinations	MTHFR	PGX
captopril	ACE	PGX	l-phenylalanine	PAH	PGX
carbamazepine	HLA-A	CPIC	l-tryptophan	SLC22A2	PGX
carbamazepine	HLA-A	FDA	lamivudine;lopinavir;ritonavir;zidovudine	ABCB1	PGX
carbamazepine	HLA-B	CPIC	lamotrigine	UGT1A4	PGX
carbamazepine	HLA-B	FDA	lansoprazole	CYP2C19	CPIC
carbamazepine	CYP3A5	PGX	lansoprazole	CYP2C19	DPWG
carbamazepine	SCN1A	PGX	lansoprazole;omeprazole;rabeprazole	IL1B	PGX
carbamazepine;clobazam;ethosuximide;lamotrigine;levetiracetam;oxcarbazepine;valproic acid	SCN1A	PGX	lansoprazole;tacrolimus	ABCB1	PGX
carbamazepine;oxcarbazepine	SCN1A	PGX	lapatinib	HLA-DQA1	FDA
carbamazepine;phenobarbital;phenytoin;valproic acid	CYP1A1	PGX	lapatinib	HLA-DRB1	FDA
carbamazepine;phenytoin;valproic acid	GABRA1	PGX	latanoprost	ABCC4	PGX
carbocisteine	PAH	PGX	ledipasvir;sofosbuvir	IFNL3;IFNL4	PGX
carboplatin;cisplatin	EIF3A	PGX	leflunomide	ESR1	PGX
carboplatin;cisplatin;docetaxel;erlotinib;gefitinib;paclitaxel	MAP3K1	PGX	lenalidomide;thalidomide	CTNNB1	PGX
carboplatin;cisplatin;docetaxel;gemcitabine;paclitaxel	RAF1	PGX	letermovir	SLCO1B1	PGX
carboplatin;cisplatin;docetaxel;paclitaxel		PGX	letrozole	ESR1	PGX
carboplatin;cisplatin;fluorouracil	SLC19A1	PGX	levodopa	HOMER1	PGX
carboplatin;cisplatin;gemcitabine	GPX5	PGX	levodopa	SLC6A3	PGX
carboplatin;cisplatin;oxaliplatin;platinum;Platinum compounds	ERCC1	PGX	liraglutide	GLP1R	PGX
carboplatin;cyclophosphamide;thiotepa	ALDH1A1	PGX	lisinopril	ACE	PGX
carboplatin;docetaxel;paclitaxel	BCL2	PGX	lithium	ASIC2	PGX
carboplatin;docetaxel;trastuzumab	ERBB3	PGX	lithium;valproic acid		PGX
carboplatin;gemcitabine	CYP2C8	PGX	lofexidine	CYP2D6	FDA
carboplatin;lonafarnib;paclitaxel	FNTB	PGX	lopinavir	SLCO1B1	PGX
carboplatin;paclitaxel	MAD1L1	PGX	lorazepam	UGT2B15	PGX
carboplatin;paclitaxel	SLCO1B3	PGX	losartan	STK39	PGX
carboplatin;taxanes	GSR	PGX	lovastatin	LDLR	PGX
carisoprodol	CYP2C19	FDA	lovastatin acid	SLCO1B1	PGX
carvedilol	CYP2D6	FDA	lumacaftor	CFTR	PGX
carvedilol	ADRB2	PGX	lumefantrine	CYP3A4	PGX
catecholamines	ADRB1	PGX	lurasidone	HTR1A	PGX
catecholamines;metformin	SLC22A3	PGX	Measles vaccines	TLR3	PGX
cavosonstat	CFTR	PGX	meclizine	CYP2D6	FDA
cefotaxime	SLC22A8	PGX	meloxicam	CYP2C9	CPIC
ceftriaxone	ABCG2	PGX	melphalan	SLC7A5	PGX
celecoxib	CYP2C9	FDA	memantine	NR1I2	PGX
celecoxib	ALOX12	PGX	mephenytoin	CYP2C19	PGX
cerivastatin	SLCO1B1	PGX	mercaptopurine	NUDT15	CPIC
cetuximab	EGF	PGX	mercaptopurine	TPMT	CPIC
cetuximab;irinotecan;leucovorin;tegafur	EGFR	PGX	mercaptopurine	TPMT	FDA
cetuximab;irinotecan;panitumumab	AREG	PGX	mercaptopurine	FTO	PGX
cetuximab;panitumumab	KRAS	PGX	mercaptopurine	NUDT15	PGX
cevimeline	CYP2D6	FDA	mercaptopurine;methotrexate	ITPA	PGX
chlorothiazide;hydrochlorothiazide		PGX	metformin	SLC22A1	PGX
chlorpromazine;clozapine;haloperidol;olanzapine;quetiapine;risperidone;trifluoperazine	EPM2A	PGX	metformin	SLC47A1	PGX
chlorthalidone;lisinopril	MMP3	PGX	metformin;sulfonamides, urea derivatives	KCNJ11	PGX
cisplatin	ACYP2	PGX	methacholine	ADRB2	PGX
cisplatin	ERCC1	PGX	methadone	ABCB1	PGX
cisplatin;cyclophosphamide	CYP2E1	PGX	methadone	CYP3A4	PGX
cisplatin;cyclophosphamide	GSTM3	PGX	methamphetamine	FAAH	PGX
cisplatin;cyclophosphamide;doxorubicin;methotrexate;vincristine	ABCC3	PGX	methotrexate	ATIC	PGX
cisplatin;fluorouracil	GALNT14	PGX	methotrexate	MTHFR	PGX
cisplatin;fluorouracil;mitoxantrone	GALNT14	PGX	methotrexate	SLC19A1	PGX
cisplatin;fluorouracil;oxaliplatin	VEGFA	PGX	methoxyflurane	CACNA1S	PGX
cisplatin;fluorouracil;radiotherapy	MUTYH	PGX	methylphenidate	CES1	PGX
cisplatin;gemcitabine	RRM1	PGX	methylphenidate	DRD2	PGX
cisplatin;irinotecan	UBE2I	PGX	methylphenidate	SLC6A2	PGX
cisplatin;oxaliplatin;Platinum compounds	GSTP1	PGX	methylprednisolone;prednisolone	ABCB1	PGX
cisplatin;oxaliplatin;platinum;Platinum compounds	ERCC2;KLC3	PGX	metoclopramide	CYP2D6	FDA
cisplatin;pemetrexed	ABCC2	PGX	metoprolol	CYP2D6	DPWG
citalopram	CYP2C19	CPIC	metoprolol	CYP2D6	FDA
citalopram	CYP2C19	DPWG	metoprolol	ADRB1	PGX
citalopram	CYP2C19	FDA	midazolam	POR	PGX
citalopram	HTR2A	PGX	migalastat	GLA	PGX
citalopram;escitalopram		PGX	milnacipran	HTR1A	PGX
citalopram;fluoxetine	GSK3B	PGX	mirabegron	CYP2D6	FDA
citalopram;fluoxetine;paroxetine;sertraline	REEP5	PGX	mirtazapine	FKBP5	PGX
cladribine;cytarabine	RRM1	PGX	mirtazapine;venlafaxine	TPH2	PGX
cladribine;fluorouracil;gemcitabine	NT5C1A	PGX	mitotane	CYP2B6	PGX
clobazam	CYP2C19	FDA	mivacurium	BCHE	FDA
clodronate	VDR	PGX	modafinil	ABCB1	PGX
clomipramine	CYP2C19	CPIC	montelukast	LTA4H	PGX
clomipramine	CYP2C19	DPWG	morphine	KCNJ6	PGX
clomipramine	CYP2D6	CPIC	morphine	OPRM1	PGX
clomipramine	CYP2D6	DPWG	morphine;nortriptyline	ABCB1	PGX
clomipramine	CYP2D6	FDA	muraglitazar	EDN1	PGX
clomipramine;liothyronine;lithium;nefazodone;venlafaxine	HTR1B	PGX	mycophenolate mofetil	SLCO1B3	PGX
clomipramine;lithium;nefazodone;paroxetine;venlafaxine	ABCB1	PGX	mycophenolic acid	SLCO1B3	PGX
clomipramine;nefazodone;paroxetine;venlafaxine	FKBP5	PGX	naloxone	OPRM1	PGX
clonidine	GNB3	PGX	naltrexone	DBH	PGX
clopidogrel	CYP2C19	CPIC	naproxen	CYP2C9	PGX
clopidogrel	CYP2C19	DPWG	nateglinide	SLCO1B1	PGX
clopidogrel	CYP2C19	FDA	nebivolol	CYP2D6	FDA
clopidogrel	CES1	PGX	nelfinavir	CYP2C19	PGX
clozapine	CYP2D6	FDA	nemonapride	ANKK1	PGX
clozapine	ABCB1	PGX	nevirapine	CYP2B6	PGX
clozapine	HTR2C	PGX	nicotine	CHRNA3	PGX
clozapine	NTRK2	PGX	nicotine	CHRNA5	PGX
clozapine;olanzapine	MC4R	PGX	nicotine;Opium alkaloids and derivatives	CHRNA5	PGX
clozapine;olanzapine;risperidone	DRD2	PGX	nifedipine	SLC14A2	PGX
cocaine	DRD2	PGX	nilotinib	UGT1A1	FDA
cocaine	OPRM1	PGX	nimodipine	CACNA1C	PGX
cocaine;ethanol;nicotine	OPRM1	PGX	nitrendipine	AGTR1	PGX
cocaine;heroin	OPRM1	PGX	nitroprusside	ACE	PGX
codeine	CYP2D6	CPIC	nitrous oxide	MTHFR	PGX
codeine	CYP2D6	DPWG	nortriptyline	CYP2D6	CPIC
codeine	CYP2D6	FDA	nortriptyline	CYP2D6	DPWG
codeine	OPRM1	PGX	nortriptyline	CYP2D6	FDA
conjugated estrogens	SULT1A1	PGX	nortriptyline	ABCB1	PGX
conjugated estrogens;medroxyprogesterone	VDR	PGX	nortriptyline	GNB3	PGX
corticosteroids	BCL2L11	PGX
corticosteroids	CRHR1	PGX
corticosteroids;selective beta-2-adrenoreceptor agonists	ADRB2	PGX
cotinine	CHRNA5	PGX
cotinine glucuronide	UGT1A9	PGX
cotinine;nicotine	OPRM1	PGX
coumarin	CYP2A6	PGX
creatine	MOBP	PGX
curcumin;ivacaftor	CFTR	PGX
cyclophosphamide	ABCC4	PGX
cyclophosphamide	CYP2C19	PGX
cyclophosphamide	SOD2	PGX
cyclophosphamide;cytarabine;daunorubicin;mercaptopurine;methotrexate;prednisone;vincristine	DROSHA	PGX
cyclophosphamide;dexamethasone;lenalidomide;thalidomide	CTNNB1	PGX
cyclophosphamide;docetaxel	VEGFA	PGX
cyclophosphamide;docetaxel;doxorubicin;epirubicin;fluorouracil	SLCO1B1	PGX
cyclophosphamide;doxorubicin	CYP2C19	PGX
cyclophosphamide;doxorubicin;fluorouracil	ATM	PGX
cyclophosphamide;doxorubicin;fluorouracil	SLC22A16	PGX
cyclophosphamide;doxorubicin;fluorouracil;methotrexate	NOS3	PGX
cyclophosphamide;doxorubicin;prednisone;rituximab;vincristine	GSTA1	PGX
cyclophosphamide;epirubicin	GSTP1	PGX
cyclophosphamide;epirubicin;fluorouracil	NQO1	PGX
cyclophosphamide;epirubicin;fluorouracil	PIGB	PGX
cyclophosphamide;epirubicin;paclitaxel	CYP1B1	PGX
cyclophosphamide;fluorouracil;methotrexate	FGFR4	PGX
cyclosporine	CYP3A4	PGX
cyclosporine	CYP3A5	PGX
cyclosporine;dicloxacillin	ABCB1	PGX
cyclosporine;mycophenolate mofetil	IL10	PGX
cyclosporine;mycophenolate mofetil;sirolimus;tacrolimus	UGT1A8	PGX
cyclosporine;mycophenolic acid	ABCC2	PGX
cyclosporine;sirolimus;tacrolimus	TCF7L2	PGX
cyclosporine;tacrolimus	CRTC2	PGX
cysteamine	CFTR	PGX
cytarabine	CDA	PGX
cytarabine;daunorubicin;dexrazoxane;idarubicin	ABCB1	PGX
cytarabine;daunorubicin;etoposide;mitoxantrone	SLCO1B1	PGX
cytarabine;fludarabine;gemtuzumab ozogamicin;idarubicin	CYP2E1	PGX
cytarabine;idarubicin	NT5C3A	PGX

Summary

There you have it! With information, free is not always good and useful. A lot of users come to Xcode after having tried Promethease for $5. If you just want to satisfy your curiosity and not really looking for anything specific, then Promethease may be the way to go. But, if you want specific, organized, and actionable insights from your genetic data about your health and wellbeing, then you certainly must try the Xcode Health reports!

About Xcode Life

Updated on January 15^th, 2022

GEDmatch is primarily a free website and a powerful genealogy tool that lets users upload their DNA raw data files to find related individuals. It offers a bunch of free tools as well as some paid tools. Read on to know how to get started with GEDmatch for in-depth research about your family history!

What is GEDmatch ?

GEDmatch is a free genealogy website where users can upload their DNA raw data files to track down family members and learn more about their family history.

More reading: What is a DNA raw data file?

Who owns GEDMatch?

Cofounded by Curtis Rogers and John Olson in 2010, it is now owned by Verogen and is based in San Diego, CA. With a global genealogical database and 45+ genetic tools, GEDmatch focuses on genealogy research to provide accessible and effective data to its consumers.

What are the different services offered by GEDMatch?

GEDmatch allows you to compare your DNA raw data using a variety of easy-to-use applications, most of which are free. The services include 45+ genetic tools which help understand and explore your DNA and ancestry.

Is GEDMatch free?

The following are the free tools offered by GEDMatch:

One-to-Many DNA Comparison:

The One-to-Many DNA Comparison tool can be a great place to start. This tool provides a list of people that you share chromosome segments with, along with their email IDs for quick contact. You can also sort and filter your matches.

"Total cM" (centimorgans) refers to the total length of all substantial DNA segments you share with a DNA match. The larger the number of centimorgans you share with another user, the more closely you are related.

"Overlap" is the total number of SNPs or single nucleotide polymorphisms that you share with your match.

One-to-One Autosomal DNA Comparison:

A one-to-one autosomal DNA comparison enables you to make detailed comparisons of two DNA profiles. The results include a list of shared chromosomes and their locations on the genome. You can view your results in tabular or graphical format, or both.

 How to use the GEDMatch Admixture tool?

This tool allows you to see the percentage of each ethnicity in your DNA, displayed as a simple pie chart. There are also different calculators which provide specialized results for specific ethnicities.

There are 7 projects to choose from in the Admixture (Heritage) tool.

1. MDLP: Global calculator
2. Eurogenes: European background
3. Dodecad: Eurasian background
4. Harappa world: South Asian ancestry
5. Ethiohelix: African ancestry project
6. puntDNAL - Ancient DNA
7. GedrosiaDNA - Eurasian background

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• 

3D Chromosome Browser

With this tool, you can examine segment matches between several individuals at the same time (up to 10). You can quickly identify shared common segments, which may indicate a single common ancestor for multiple people. The graphics used to display the results may not work in certain browsers.

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• 

What are the different premier tier tools in GEDMatch?

Segment Search: With this tool, you can search your top matches for overlapping segments. This can help you identify matches that share the most recent common ancestors.

Q-Matching Enhanced One-to-One: This tool is similar to the one-to-one comparison tool and compares your DNA with the DNA of a match. Additionally, it examines the quality of the shared segments.

Phasing Tool: It attempts to separate your paternal and maternal autosomal DNA.

Cluster Tool: This is a sorting feature that groups your matches into clusters based on the degree of similarity, indicating descent from a recent common ancestor."

These Tier 1 tools enable complex genealogy research and help investigate your DNA at a much more advanced level.

How to use GEDMatch?

1. Sign-up and create a new user account
2. Once that is done, you will receive an email containing a 6-digit code that you need to key in to complete user registration.
3. Once the registration is complete, you can log in to your account.
4. The display page will provide a link for new users providing information on how to use GEDmatch.

The page also displays the following information for signed-in users:

• Profile Information
• A list of free tools 
• A list of Tier 1 tools 
• Membership Upgrade Details
• Links to other information, including terms of conditions

How to upload your raw data from 23andMe, AncestryDNA or Family Tree DNA to GEDMatch?

1. Click on "Upload" from the header section of the home page.
2. Fill in the form with as much information as you have.
3. Click on the "Choose File" button at the bottom of the page.
4. Choose the correct file from your device - Your data must be Build 37 (GRCh37/hg19)
5. Click the upload button and wait until you see the word "Finish."

How much does GEDMatch analysis cost?

GEDmatch is predominantly free, with an option to pay for access to more advanced tools.

Three basic genealogy analysis tools (one-to-one, one-to-many, and admixture), along with 45+ other genealogic analysis tools, are available for free on your account.

Apart from these, you can gain access to more complex tools from the Tier 1 subscription priced at $10/month. The Tier 1 plan offers a choice between auto-renewal and an on-demand payment option.

Is it safe to upload your DNA raw data to GEDMatch?

GEDmatch collects your name, an optional alias, and email address for your registration. Once registered, other personal information such as your sex, genetic information, genealogy data, and payment information can be provided with consent. 

GEDmatch automatically collects certain information regarding visitors to their site, solely for internal purposes, such as site improvement. This includes your IP address, browsing actions, information about your equipment, and usage patterns. 

The site may use third-party tools to help understand statistical data about its visitors. GEDmatch does not reveal any personal information to these tools. 

When you upload your DNA to GEDmatch, you can opt for one of the four privacy options:

Private: DNA data is not available to other people.

Public + opt-in: DNA data is available for one-to-many searches, including law enforcement searches.

Public + opt-out: DNA data is available for comparison to any raw data in the GEDmatch database, except law enforcement searches.

Research: DNA data is available for one-to-one comparison with public or research DNA. It does not allow one-to-many searches.

GEDmatch confirmed a breach in data privacy in July 2020, after genetic information was made available to the police. For further information, you can read GEDmatch's Privacy Policy.

GEDMatch Reviews

GEDmatch is a standard tool that is recommended among various genealogy groups on Facebook. It has also proved to be useful for law enforcement investigations to solve crimes. GEDmatch helped with the arrest of the Golden State Killer, responsible for more than 50 rapes and at least 13 murders in California in the 1970s and 1980s. Ever since this case was solved, GEDmatch has transformed into a popular crime-solving tool.

The FBI and the police in California worked with a professional genealogist, Barbara Rae, to match DNA samples from the crime scene to GEDmatch profiles of the killer's third and fourth cousins.

Since then, GEDmatch has helped solve around 70 violent crimes. However, the site's new prominence as a crime-solving tool has divided genealogists concerned about this practice invading user privacy and those keen to work with law enforcement.

Summary - The Pros and Cons

Pros

• It has an expansive database consisting of 1.4 million users
• Access to most tools is free
• The results have high accuracy
• It allows comparison of consumers' raw data with public DNA data
• The experience is completely customizable

Cons

• It is not very user-friendly for beginners
• GEDmatch requires a fee to access advanced genealogy tools
• There are some privacy concerns

About Genetic Lifehacks

Genetic Lifehacks is a website where users can learn about the genetic connection between their diet and health. Founded by Debbie Moon in 2015, the company aims to combine an engineering mindset with biological systems and apply genetics to dietary and lifestyle choices. Genetic Lifehacks claims to use people's DNA to optimize their diets and lifestyles, based on their exact needs.

Genetic Lifehacks Services

Genetic Lifehacks offers the following products and services:

Consultation Reports

The website offers a "Top 5 Topics" report customized based on vital topics for each individual. It spans over 11-15 pages and includes the following:

-Explanation of the topic 

-Discussion of the genetic variants 

Sleep and Your Genes Report

This report analyzes 20+ genes and explains how these genes influence sleep aspects like melatonin secretion, restless leg syndrome, insomnia, and caffeine response.

The report includes the following:

• Background information on the genes
• Studies and references related to the genetic variants 

Additionally, it includes information on circadian rhythm and homeostatic sleep drive.

Xcode Life's Gene Sleep Report - 15 traits for $20

Ultimate Cheat Sheet

This cheat sheet quickly shows you which article on the website matches your gene results. It is organized into the following categories:

• Heart Disease
• Exercise
• Detoxification Pathways
• Sleep and Circadian Rhythm
• Neurotransmitters & Hormones
• Vitamins, etc.

Each category has a short article description, the risk gene, and a color-coded section for the individual genome. It also explains the different interactions of gene variants from different article sections.

Source: Genetic Life Hacks

Email Course

This free introductory course explains what genetic data means. It is a 4-day course, providing essential information on genetics. 

However, please bear in mind that Debbie Moon is not a doctor. 

She only provides information and opinions, curated using peer-reviewed research and statistics. Individuals must seek assistance from a doctor for any medical advice regarding the provided information.

Genetic Lifehacks: Getting Started

Once you subscribe to a membership plan and purchase a product, you can upload your raw DNA data file from 23andMe or AncestryDNA on the checkout page. The upload process takes about a minute. Once that is done, you can complete the checkout. 

After checkout, you will receive an email with your Top 5 Report within 1-3 business days. 

Genetic Lifehacks Pricing

Genetic Lifehacks offers a membership option to its users at the following rates:

• Monthly Plan: $6 per month
• Annual Plan: $39 per year

Genetic Lifehacks offers a range of other services for its users.

• Sleep and Your Genes Report: $29

• Ultimate Cheat Sheet: $39

• Top 5 Topics Report – Add on: $60

• Topics Consultation Report + Cheat Sheet + Annual Membership Plan: $99

About Privacy

According to their website, Genetic Lifehacks does not store personal information except when purchasing a product. 

The website collects user activity statistics and cookies to improve user experience. No tracking software is used on the website, ensuring user privacy.

If one chooses to post their personal information like name and email in the comments section, it gets recorded on the site. 

Genetic Lifehacks stores user genetic data offline on an encrypted drive. It is deleted after 30 days and not used for research. The information is used only for consultation and not shared with third parties. 

For further information, read the Genetic Lifehacks Privacy Policy.

What People Say: News & Reviews

You can learn more in the News and Research section of Genetic Lifehacks.

Trendhunter reviewed Genetic Lifehacks and scored it a 4.9.

Pros & Cons

Pros:

• The membership and reports are affordable
• The website is very informational, with 200+ articles
• It provides a cheat sheet option for easy navigation
• The website has a free email course for beginners

Cons:

• The reports are not put together by a medical professional
• The website limits reports to 5 topics
• Reports might predominantly include fun facts

	Genetic Lifehacks	Xcode Life
Type of genetic testing	DNA raw data analysis	DNA raw data analysis
Ancestry reports	Not offered	Not offered
Health reports	Not offered	Offered
Pharmacogenomic reports	Not offered	Offered
Raw data upload	Only from 23andMe and AncestryDNA	DNA raw data from all major providers accepted. Comprehensive list
Number of reports	5 topics	13
Price	Annual membership- $39Other services - $29-$99	Reports: $10-$40Bundles: $49-$99Price details
Free tools	Nil	3 free tools (Gene Tool, DNA raw data merge, DNA raw data convert) available for all
Sample reports	Nil	Available as detailed report walkthrough videos

About the Company

Gene By Gene was co-founded in 2000 by Bennett Greenspan and Max Blankfeld, with its headquarters in Houston, Texas. Currently, the company is headed by Dr. Lior Rauchberger as part of a merger with a leading Australian genomics firm, myDNA. The company’s labs are CAP, CLIA, NYSDoH, CA, and AABB accredited.

Gene By Gene laid the foundations of DNA-based ancestry and genealogy as FamilyTreeDNA (FTDNA). The first company of its kind, FTDNA, collaborated with National Geographic’s Genographic Project as their testing provider. 

Gene By Gene Services

The company was the first lab to offer DNA-based ancestry and genealogy services as its subsidiary, FamilyTreeDNA, since 2000. It has now expanded its services to clinical, forensic, and research genetics. Amid the COVID-19 pandemic, Gene By Gene has opened its door for COVID-19 testing services too. The company caters to a wide range of individuals - clinicians, consumers, and researchers - worldwide. 

Getting Started

For starters, clinicians, consumers, and researchers alike can register with the company. Upon registration, they can browse from a list of tests to place an order. The account dashboard has five tabs for browsing.

Clinicians can add as many patient profiles as they want. 

Clinicians can opt for a carrier screening test for other members of the patients’ families, too, if needed. 

Clinical Testing Service

Gene By Gene’s clinical testing services includes the following:

• Diagnostic services to confirm a disease prognosis and assist in healthcare management
• Assistance in reproductive health with carrier screening and preimplantation testing
• Predisposition tests to learn about a healthy individual’s chances of developing cancer, autoimmune disorders, and more.

The clinical testing services of Gene By Gene can be availed either as a healthcare provider (for your patient) or a consumer.

Image: Registration for genetic counselors/medical clinicians

Forensics

The company provides Investigative Genetic Genealogy (IGG) services to law enforcement organizations through its subsidiary, FamilyTreeDNA. The company has its in-house lab and many genetic genealogists who discreetly identify individuals. They do so by matching them to unknown samples of DNA from cases involving homicides or sexual assault. This is brought about by familial matching within the FamilyTreeDNA database.

Law enforcement officials can submit their case along with evidence for review to the company. The staff reviews the case and checks for sample suitability before proceeding with testing. 

Relationship DNA Testing

Gene By Gene offers a wide range of DNA testing services, including paternity, maternity, immigration, and legal testing. 

• Immigration Testing: This is offered by the company to assist immigration between the US and other countries. This is brought about in collaboration with the embassies of different countries. Upon test request, a case manager is allotted who guides through the entire testing process. The counseling sample is collected either as a buccal swab or as bloodstains (as may be required by different embassies).
• Paternity Testing: The company offers two types of paternity tests: first, court-admissible test (which you can use to change the name or get child support and other benefits), and second, Peace of Mind DNA test (for your peace of mind). Upon test requisition, a kit for collection and sample return to the company is provided to the consumer.
• Maternity Testing: The company offers maternity test services to ascertain biological mother identity in cases of:

• Reunion of the adoptee with their biological mother
• In the case of immigration, proof of biological relationships
• In case of baby mix-up in the hospital nursery, to ascertain birth mother.

Research Genetics Services

Gene By Gene offers a range of sequencing and microarray services for researchers from academic institutions, pharma companies, and hospital and medical research centers. The labs are CAP/CLIA accredited, and services are HIPAA compliant. Services provided are:

• Whole Genome Sequencing (WGS)
• Whole Exome Sequencing (WES)
• Sanger Sequencing
• Fragile X

The lab uses Illumina NovaSeq 6000 for WGS and WES services. The data is provided as FASTQ. For Fragile X service, carrier status is checked using AmplideX, FMR1. 

Ancestry Testing Service

Gene By Gene offers its ancestry testing service through its DTC (direct-to-consumer) genetic testing subsidiary, FamilyTreeDNA. This service has an entirely separate website from where clients can access Ancestry Testing's services. The consumer can sign up and start ordering kits with the specific service.

The different DNA tests offered are:

1. Family Finder - This test focuses on autosomal DNA and finds living relatives on all ancestral lines. This analysis is represented as a percentage breakdown of the different regions of the world from where the consumer's ancestors might have belonged. The test also provides a list of matching individuals who share common ancestors tracing back to five generations.
2. Y-DNA - This test is for males only. It traces the consumer's direct patriarchal line of descent. The test provides a list of matches who share a standard patriarchal ancestral line tracing to 25 generations. This test is unique as it gives a migrational route of the genetic population of your paternal line - haplogroup - which can be used to find out more about the consumer's genealogy.
3. mtDNA - This test traces the matriarchal line of descent. It also provides a list of matches that share common matriarchal ancestors tracing back to 52 generations. Additionally, it also traces an ancestral migrational route tracing back 1000 years. 

You can check out our detailed review of Family Tree DNA services here

myOrigins

A part of the Family Finder test, this feature gives a percentile breakdown of the populations to which your autosomal DNA is connected. It can be accessed either from the navigation bar or from the consumer login dashboard.

This feature has two tabs:

• myOrigins tab shows the percentile breakdown for the consumer’s ethnic makeup shown as population clusters. 
• The shared origins tab shows the list of shared matches.

DNA match list

The three tests (Family Finder, Y-DNA, and mtDNA) have separate databases of people who undertake each test. Therefore, upon a consumer doing either of the three tests, his data are matched with people who had undertaken the test before and checked for common ancestral descent. This information builds the base for the share origins tab of the myOrigins feature.

Carrier Screening Service

Gene By Gene provides a comprehensive carrier screening service that includes panel tests with 253 autosomal and X-linked recessive conditions (all conditions included by the American College of Medical Genetics and American Congress of Obstetricians and Gynecologists). A simple cheek swab collects the sample for the screening test. The test results are ready in 2 weeks. 

The company also provides complimentary genetic counseling services upon reception of carrier screening results. The service can be directly accessed by contacting Gene By Gene and scheduling an appointment.

Image: Snippet of Carrier Status Report

Xcode Life’s Carrier Status Report - 360+ Traits, $40 - No DNA test required

Additional features

Tryptase CNV (copy number variation)

This test is used to determine the alpha tryptase copy number. It can be requested by healthcare providers, researchers, and consumers to check for serum tryptase levels. Suppose consumers order a test themselves; in that case, the test request form must be approved and signed by the consumer’s healthcare provider. 

* Note: Alpha tryptase is produced by the gene TPSAB1 and beta tryptase by genes TPSAB1 and TPSAB2. Individuals with one copy of inherited α-tryptase on the gene sequence have normal serum tryptase levels. 

Understanding results: 

• A typical result is any combination of both α- and β- tryptase adding up to 4 on both strands of DNA. 
• A positive result is a combination of α- and β- tryptase adding up to five or higher on both strands due to duplication or triplication of α-tryptase. 

Eligibility criteria for testing:

• Patients exhibiting symptoms of 

• High tryptase level of 8 or more
• Cutaneous flushing, itching, and severe allergic reactions
• Dysautonomia
• Chronic pain
• Connective tissue abnormalities
• Patients with a diagnosis of 

• Mast cell activation syndrome (MCAS)
• Postural orthostatic tachycardia syndrome (Dysautonomia)
• Gastroparesis
• Ehlers-Danlos Syndrome

For more information: https://genebygene.com/tryptase/#resources https://genebygene.com/tryptase/#w-tabs-1-data-w-pane-1 

Health report

The FamilyTreeDNA website of Gene By Gene has an additional feature of the Health report. This report includes: 

• Health conditions - This includes carrier screening (screening of 365+ severe pathogenic variants), organ system diseases (screening for diseases affecting all major organ systems), evaluation of 59 secondary or incidental conditions, and gives the risk of illness insights and gives cancer predisposition status for 12+ types of cancer.
• Fitness and Nutrition Traits include nine fitness traits, eight nutrigenomics traits, and five additional lifestyle traits.
• Medication Response and Education - This includes insights into the metabolism and efficient dosages of medications and further information about conditions. 

Upon receiving the report, a free-of-cost, half an hour telemedicine appointment with a consulting physician (or a genetic counselor) is scheduled to give the consumer a proper interpretation of their report.

Xcode Life’s Gene Health Report - 55 Traits, $20 - No DNA test required

Pricing

Test	Pricing
Court Admissible Paternity Test	$425
Peace of Mind DNA Test (paternity)	$189
Court Admissible Maternity Test	$475
Family Finder	$79 $59
mtFull Sequence	$159 $139
YDNA37	$119 $109
YDNA111	$249 $219
Big Y-700	$449 $399
Tovana Health Report + Family Finder	$899 $879

About Gene By Gene Privacy

The company claims to respect consumer privacy and does not sell or rent out personal information of any kind to a third party without the consumers’ consent.

The company only collects and stores consumer data to operate effectively and provide the best experience of its products. Personal information includes, but is not limited to, names, phone numbers, physical or mailing addresses, email addresses, and genetic test results.

The company uses the stored data to communicate about test progress and results and marketing communications occasionally. One can opt out at any time.

The information is stored in the company headquarters, adjacent to the Genomics Research Center in Houston, Texas.

In addition to Gene By Gene’s Privacy Policy, FamilyTreeDNA adheres to the Genetic Genealogy Guidelines proposed by the Genetic Genealogy Standards Committee in January 2015.

For more information, read Gene By Gene’s privacy policy.

News

In 2018, in collaboration with Dr. Barbara Rae Venter, Gene By Gene helped law enforcement officials arrest the “Golden State Killer” through its investigative genetic genealogy services. 

In January 2021, Gene By Gene went for a merger with Australian genomics firm myDNA headed by Dr. Lior Rauchberger. 

Summary: Pros and Cons

Pros

1. The company offers in-depth diagnostic clinical testing services which physicians can trust.
2. Ancestry reports have in-depth tracing, up to 10, 25, and even 52 generations.
3. Test kits are easy to use with mostly cheek swab samples.
4. Provision for trace mapping of ancestral migration routes.
5. Provision for in-house labs which guarantee discrete and uncontaminated test results.

Cons

1. Test kits are expensive.
2. The company does not offer in-depth, personalized lifestyle reports
3. Test results may take longer to be delivered, especially in the case of international consumers. 

	Gene By Gene	Xcode Life
Type of genetic testing	DNA kits	DNA raw data analysis
Ancestry reports	Offered (by FTDNA)	Not offered
Health report	Offered	Offered
Pharmacogenomic report	Not offered	Offered
Raw data upload	Only autosomal DNA data from AncestryDNA, 23andMe and MyHeritage	DNA raw data from all major providers accepted. Comprehensive list
Number of reports	2	13
Report updates	No	Quarterly updates
Price	Tests: $79 $59 - $475Health Report: $899 $879	Reports: $10-$40Bundles: $49-$99Price details
Free tools	Not available	3 free tools (Gene Tool, DNA raw data merge, DNA raw data convert) available for all
Sample reports	Only for carrier screening and Health report	Available as detailed report walkthrough videos

NB: Information on Gene By Gene as collected up till 03rd Aug 2021.