The Calcium sensing receptor (CASR) gene is associated with the synthesis of Calcium sensing receptor, a receptor that binds to calcium present in the blood. Specific alleles of this gene are known to either increase or decrease the sensitivity to calcium. Variants of the gene are shown to be associated with the levels of Calcium, Magnesium and Phosphate in the blood. There are two single nucleotide polymorphisms associated with this gene, rs17251221 and rs1801725.
The CASR protein is present on the cells of the parathyroid glands, which are associated with the secretion of the parathyroid hormone. This hormone transfers calcium from the bone into the blood, with bones acting as storage centers for calcium. When calcium levels are high, the level of parathyroid hormone is lowered and there is increased removal of calcium via kidneys, modulated by increased binding of calcium to the CASR receptor on the kidney cells.
In a genome wide association study, it was found that the SNP rs1801725 had a strong association with people of European descent while the SNP rs17251221 had a strong association with people of Indian Asian descent. These two SNPs are found to be in high linkage disequilibrium with each other. Another study showed that people with the G variant (rs17251221) of the gene were associated with increased calcium levels. Each copy of the G allele increases Calcium levels by 0.06 mg/dl.
People with the G variant (rs17251221) of the gene were associated increased magnesium levels in the serum.
People with the G (rs17251221) variant of the gene are shown to be associated with decreased Phosphate level in the serum. Increased secretion of the parathyroid hormone which results in elevated calcium levels is associated with decreased phosphate levels due to the phosphaturic effect.
People with the G variant were associated with a higher risk of stone multiplicity.
It is important to choose an appropriate diet based on the genetic profile.
For people with G (rs17251221)
For people with A variant (rs17251221)
For people with T (rs1801725)
For people with G variant (rs1801725)
“Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”