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Know Your Genes: GABPB1 “ The Energy Gene”

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Aerobic Capacity
Endurance

GAbinding protein (GABP) transcription factor gene, also known as the Nuclear Respiratory Factor 2 (NRF2) gene is associated with the synthesis of GABPB1, a key transcriptional activator of numerous nuclear genes which produce various mitochondrial enzymes. The variants of the GABPB1 gene that code for the beta1 subunit of NRF2 protein have been shown to be associated with endurance. Specific alleles of this gene are known to either increase or decrease GABPB1 which stimulates mitochondrial biogenesis upon exercising.

Association with Running:

A study conducted on track and field athletes showed that people with the A variant of the gene were more common among endurance athletes than non-athletes. In a similar study conducted on elite endurance, elite power and non-athletes, it was found that people with the A variant were found to be more common among elite endurance athletes.

Association with Aerobic Capacity:

People with the A variant of the gene were associated with better baseline aerobic capacity and an increase in VO2 max upon aerobic training, when compared with people with the C variant of the gene.

Genotype 

Phenotype

AA
  • [Advantage] More likely to improve VO2 max on training
  • [Advantage] More likely to have better aerobic capacity
  • [Advantage] Better endurance ability
AC
  • Moderate endurance and moderate aerobic capacity
CC
  • [Limitation]Less likely to improve VO2 max on training
  • [Limitation] More likely to have lower aerobic capacity
  • [Limitation] Lower endurance ability than people with the A variant

 

How can this information be used?

It is important to choose an appropriate diet based on the genetic profile

 

For people with A variant (Better Endurance)

  • Likely better at endurance running and better aerobic capacity.
  • Tennis, dancing and participating in marathons are some endurance based activities

 

For people with G variant (Lower Endurance)

  • Likely poor at endurance running
  • Endurance based activities would require additional training and more effort.


References
:

  1. https://www.ncbi.nlm.nih.gov/pubmed/?term=17357964
  2. https://www.ncbi.nlm.nih.gov/pubmed/22749526?dopt=Abstract
  3. https://www.ncbi.nlm.nih.gov/pubmed/20028934
Find out which variation of the gene you carry and more at www.xcode.in

Nutrigenetics, fitness genetics, health genetics are all nascent but rapidly growing areas within human genetics. The information provided herein is based on preliminary scientific studies and it is to be read and understood in that context.”

Amrita Surendranath
Amrita Surendranath
Amrita has a Masters in Human Genetics which fuelled her passion for genes and their diktats. She loves converting genetic research into exciting scientific news with a punch. 10 years on, her interesting insights have covered a range of topics that include cancer, diabetes, nutrition, fitness and more. A pulse on what’s interesting aids in decoding laboratory data into useful science that could empower people into molding healthier lifestyles.