The Fatty Acid Desaturase (FADS1) gene is associated with the synthesis of FADS1 protein, an enzyme secreted in the liver and shown to be associated with the conversion of shorter chain fatty acids to longer length active forms. The FADS1 protein is found to be associated with the conversion of omega 3 and omega 6 […]
The human Hemochromatosis Protein (HFE) gene is associated with the synthesis of HFE protein. This protein has been shown to be associated with the regulation of the circulating iron by regulating the interaction of the transferrin receptor with transferrin. The concentration of iron in the blood is detected by a complex of HFE, transferrin receptor […]
FUT2 Gene: An Introduction The FUT2 gene is located on the long arm of chromosome 19. The FucosylTransferase 2 (FUT2) gene is associated with the synthesis of fucosyltransferase 2. This enzyme found to attach the bacterium Helicobacter pylori to the gastric mucosa, which affects the absorption of vitamin B12 in the gut. People with the […]
Transmembrane Protease, Serine 6 (TMPRSS6) gene is associated with the synthesis of transmembrane protease, serine 6 (also known as matriptase-2), a liver serine protease. TMPRSS6 cleaves the bone morphogenetic protein (BMP) and down-regulates the iron hormone hepcidin, facilitating iron absorption. Inactivation of TMPRSS6 is associated with iron deficiency anemia. There are two single nucleotide polymorphisms […]
GA‐binding protein (GABP) transcription factor gene, also known as the Nuclear Respiratory Factor 2 (NRF2) gene is associated with the synthesis of GABPB1, a key transcriptional activator of numerous nuclear genes which produce various mitochondrial enzymes. The variants of the GABPB1 gene that code for the beta1 subunit of NRF2 protein have been shown to […]
The Alpha-Tocopherol Transfer Protein (TTPA) gene is associated with the synthesis of alpha-tocopherol transfer protein, a fat-soluble antioxidant that is secreted by the liver, together with low-density lipoproteins into the bloodstream. Variants of this gene are associated with an increase or decrease in the level of Alpha-Tocopherol Transfer Protein, which corresponds to an increase or […]
The Melanocortin 4 Receptor gene (MC4R) is associated with the synthesis of MC4R enzyme, a G protein coupled receptor which is found to bind to alpha melanocyte stimulating hormone. Among humans, this gene is shown to be associated with obesity. There are two SNPs that are used in our panel, rs17782313 and rs12970134 Association with […]
The Human Leukocyte Antigen system (HLA) gene is associated with the synthesis of Major Histocompatibility Complex (MHC), which are cell surface proteins that are associated with the regulation of the immune system. There are six single nucleotide polymorphisms of this gene complex, HLA DQ(rs7454108), HLA DQ 2.5 (rs2187668), HLA DQ 2.2 (rs7775228, rs2395182, rs4713586) and […]
ACE gene: An introduction ACE gene codes for Angiotensin-Converting Enzyme. This enzyme is a part of the Renin-Angiotensin System, which is responsible for maintaining blood pressure, and fluid and salt balance in the body. The enzyme cleaves the protein angiotensin I at a particular site, converting it into angiotensin II. This angiotensin II brings about […]
