The PPARGC1A gene is associated with the synthesis of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a), which is associated with mitochondrial biogenesis or the production of new mitochondria within the muscle. Specific alleles of this gene are known to either increase or decrease the levels of PGC-1a. People with the A variant of the gene […]
The β2 adrenergic receptor 2 (ADRB2) gene is associated with the synthesis of β2 adrenergic receptor 2, a cell membrane spanning receptor that binds to adrenaline. Specific alleles of this gene are known to either increase or decrease the sensitivity of the body to the effects of adrenaline. Variants of the gene are shown to […]
The Vascular Endothelial Growth Factor (VEGFA) gene is associated with the synthesis VEGFA, a molecule associated with the formation of new blood vessels (angiogenesis) upon training. This adaptation allows the body to increase supply of nutrients and oxygen to the trained muscles as well as remove waste products. VEGFA is associated indirectly with the widening […]
The Nitric Oxide Synthase 3 (NOS3) gene is associated with the synthesis of endothelial nitric oxide synthase (eNOS), an enzyme which facilitates the production of Nitric Oxide (NO). NO is shown to be associated with the widening of blood vessels by relaxing the smooth muscle cells within their walls, this has been shown to increase […]
The MCT1 gene is associated with the synthesis of MCT1, a molecule that transports lactic acid across the muscle cell membrane. Specific alleles of this gene are known to either increase or decrease the risk for fatigue and muscle injury after intense exercises. People with the T variant of the gene are associated with lower […]
The skeletal muscle consists of two types of fibers - fast twitch and slow twitch. The slow twitch fibers work efficiently for a long period of time while the fast twitch fibers are responsible for the short and sudden burst of power necessary for sprinting or weightlifting. The ACTN3 gene is associated with the synthesis […]
Osteoporosis, a bone disease affecting seniors and menopausal women is a growing concern causing over 8.9 million fractures each year worldwide (Johnell et al, 2006). In India, there are an estimated 25 million people who may be suffering from osteoporosis. Both men and women are affected with the disease at an earlier age compared to […]
The COL5A1 gene is associated with the synthesis of type V collagen, a key constituent of ligaments and tendons. Specific alleles of this gene are known to either increase or decrease the risk of injury. Does your 23andme, Ancestry DNA, FTDNA raw data have COL5A1 gene variant information? CHIP Version COL5A1 SNPs 23andMe (Use your […]
A healthy weight is maintained during a state of energy balance- when the energy intake of an individual matches the energy expenditure. Weight can accrue over a long period of time if the intake is higher than expenditure. Besides intake and expenditure, other factors such as age, basal metabolism, hormonal imbalance, and genetics also influence […]
